Prenatal exposure to persistent organic pollutants and metals and problematic child behavior at 3–5 years of age: a Greenlandic cohort study

Abstract High levels of persistent organic pollutants (POPs) and heavy metals are found in Arctic populations. POP and heavy metals are linked to impaired cognitive development. This study examined associations between prenatal POP and metals exposure and problematic child behavior using the Strengt...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Simon Kornvig, Maria Wielsøe, Manhai Long, Eva Cecilie Bonefeld-Jørgensen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/320363068d324bf1b1c979ccee8f634c
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:320363068d324bf1b1c979ccee8f634c
record_format	dspace
spelling	oai:doaj.org-article:320363068d324bf1b1c979ccee8f634c2021-11-14T12:21:57ZPrenatal exposure to persistent organic pollutants and metals and problematic child behavior at 3–5 years of age: a Greenlandic cohort study10.1038/s41598-021-01580-02045-2322https://doaj.org/article/320363068d324bf1b1c979ccee8f634c2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-01580-0https://doaj.org/toc/2045-2322Abstract High levels of persistent organic pollutants (POPs) and heavy metals are found in Arctic populations. POP and heavy metals are linked to impaired cognitive development. This study examined associations between prenatal POP and metals exposure and problematic child behavior using the Strength and Difficulties Questionnaire (SDQ). POPs and metals were measured in 102 pregnant Greenlandic women. During follow-up at 3–5 years, parents answered an assisted questionnaire including children’s SDQ scores. Associations were analyzed using linear and logistic regression analyses and adjusted for maternal plasma cotinine, educational level and age at delivery. In the adjusted analyses, the medium tertile of hexachlorobenzene (β = 3.06, p = 0.010), β-hexachlorocyclohexane (β = 3.58, p = 0.004) and trans-nonachlor (β = 2.06, p = 0.082) were positively associated with SDQ scores. The continuous cis-nonachlor (OR = 1.09, p = 0.079), dichloro-diphenyl-dichloroethylene (OR = 1.01, p = 0.077), trans-nonachlor (OR = 1.01, p = 0.091), and sum Organochlorine-Pesticides (OR = 1.00, p = 0.094) were positively associated with abnormal SDQ score and the continuous mirex (OR = 1.28, p = 0.096), oxychlordane (OR = 1.04, p = 0.066), and trans-nonachlor (OR = 1.02, p = 0.071) with abnormal hyperactivity score. We found no consistent evidence of associations between polychlorinated biphenyls, perfluoroalkylated substances and heavy metals and problematic behavior. Prenatal organochlorine pesticide exposure associated significantly with problematic behavior in 3–5 year old children.Simon KornvigMaria WielsøeManhai LongEva Cecilie Bonefeld-JørgensenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-18 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Simon Kornvig Maria Wielsøe Manhai Long Eva Cecilie Bonefeld-Jørgensen Prenatal exposure to persistent organic pollutants and metals and problematic child behavior at 3–5 years of age: a Greenlandic cohort study
description	Abstract High levels of persistent organic pollutants (POPs) and heavy metals are found in Arctic populations. POP and heavy metals are linked to impaired cognitive development. This study examined associations between prenatal POP and metals exposure and problematic child behavior using the Strength and Difficulties Questionnaire (SDQ). POPs and metals were measured in 102 pregnant Greenlandic women. During follow-up at 3–5 years, parents answered an assisted questionnaire including children’s SDQ scores. Associations were analyzed using linear and logistic regression analyses and adjusted for maternal plasma cotinine, educational level and age at delivery. In the adjusted analyses, the medium tertile of hexachlorobenzene (β = 3.06, p = 0.010), β-hexachlorocyclohexane (β = 3.58, p = 0.004) and trans-nonachlor (β = 2.06, p = 0.082) were positively associated with SDQ scores. The continuous cis-nonachlor (OR = 1.09, p = 0.079), dichloro-diphenyl-dichloroethylene (OR = 1.01, p = 0.077), trans-nonachlor (OR = 1.01, p = 0.091), and sum Organochlorine-Pesticides (OR = 1.00, p = 0.094) were positively associated with abnormal SDQ score and the continuous mirex (OR = 1.28, p = 0.096), oxychlordane (OR = 1.04, p = 0.066), and trans-nonachlor (OR = 1.02, p = 0.071) with abnormal hyperactivity score. We found no consistent evidence of associations between polychlorinated biphenyls, perfluoroalkylated substances and heavy metals and problematic behavior. Prenatal organochlorine pesticide exposure associated significantly with problematic behavior in 3–5 year old children.
format	article
author	Simon Kornvig Maria Wielsøe Manhai Long Eva Cecilie Bonefeld-Jørgensen
author_facet	Simon Kornvig Maria Wielsøe Manhai Long Eva Cecilie Bonefeld-Jørgensen
author_sort	Simon Kornvig
title	Prenatal exposure to persistent organic pollutants and metals and problematic child behavior at 3–5 years of age: a Greenlandic cohort study
title_short	Prenatal exposure to persistent organic pollutants and metals and problematic child behavior at 3–5 years of age: a Greenlandic cohort study
title_full	Prenatal exposure to persistent organic pollutants and metals and problematic child behavior at 3–5 years of age: a Greenlandic cohort study
title_fullStr	Prenatal exposure to persistent organic pollutants and metals and problematic child behavior at 3–5 years of age: a Greenlandic cohort study
title_full_unstemmed	Prenatal exposure to persistent organic pollutants and metals and problematic child behavior at 3–5 years of age: a Greenlandic cohort study
title_sort	prenatal exposure to persistent organic pollutants and metals and problematic child behavior at 3–5 years of age: a greenlandic cohort study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/320363068d324bf1b1c979ccee8f634c
work_keys_str_mv	AT simonkornvig prenatalexposuretopersistentorganicpollutantsandmetalsandproblematicchildbehaviorat35yearsofageagreenlandiccohortstudy AT mariawielsøe prenatalexposuretopersistentorganicpollutantsandmetalsandproblematicchildbehaviorat35yearsofageagreenlandiccohortstudy AT manhailong prenatalexposuretopersistentorganicpollutantsandmetalsandproblematicchildbehaviorat35yearsofageagreenlandiccohortstudy AT evaceciliebonefeldjørgensen prenatalexposuretopersistentorganicpollutantsandmetalsandproblematicchildbehaviorat35yearsofageagreenlandiccohortstudy
_version_	1718429218962931712

Prenatal exposure to persistent organic pollutants and metals and problematic child behavior at 3–5 years of age: a Greenlandic cohort study

Ejemplares similares