Long-lived self-renewing bone marrow-derived macrophages displace embryo-derived cells to inhabit adult serous cavities

Understanding the heterogeneity of peritoneal macrophages is hampered by controversy over their origin and homeostasis. Here the authors show the embryonic F4/80hi population is replaced over time by self-renewing bone marrow-derived cells transitioning from F4/80lo to F4/80hi in adult mice, and tha...

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Autores principales:	Calum C. Bain, Catherine A. Hawley, Hannah Garner, Charlotte L. Scott, Anika Schridde, Nicholas J. Steers, Matthias Mack, Anagha Joshi, Martin Guilliams, Allan Mc I. Mowat, Frederic Geissmann, Stephen J. Jenkins
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/320587b30d454079837bd3319d6310c0
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spelling	oai:doaj.org-article:320587b30d454079837bd3319d6310c02021-12-02T15:34:09ZLong-lived self-renewing bone marrow-derived macrophages displace embryo-derived cells to inhabit adult serous cavities10.1038/ncomms118522041-1723https://doaj.org/article/320587b30d454079837bd3319d6310c02016-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms11852https://doaj.org/toc/2041-1723Understanding the heterogeneity of peritoneal macrophages is hampered by controversy over their origin and homeostasis. Here the authors show the embryonic F4/80hi population is replaced over time by self-renewing bone marrow-derived cells transitioning from F4/80lo to F4/80hi in adult mice, and that such turnover is more rapid in male mice.Calum C. BainCatherine A. HawleyHannah GarnerCharlotte L. ScottAnika SchriddeNicholas J. SteersMatthias MackAnagha JoshiMartin GuilliamsAllan Mc I. MowatFrederic GeissmannStephen J. JenkinsNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Calum C. Bain Catherine A. Hawley Hannah Garner Charlotte L. Scott Anika Schridde Nicholas J. Steers Matthias Mack Anagha Joshi Martin Guilliams Allan Mc I. Mowat Frederic Geissmann Stephen J. Jenkins Long-lived self-renewing bone marrow-derived macrophages displace embryo-derived cells to inhabit adult serous cavities
description	Understanding the heterogeneity of peritoneal macrophages is hampered by controversy over their origin and homeostasis. Here the authors show the embryonic F4/80hi population is replaced over time by self-renewing bone marrow-derived cells transitioning from F4/80lo to F4/80hi in adult mice, and that such turnover is more rapid in male mice.
format	article
author	Calum C. Bain Catherine A. Hawley Hannah Garner Charlotte L. Scott Anika Schridde Nicholas J. Steers Matthias Mack Anagha Joshi Martin Guilliams Allan Mc I. Mowat Frederic Geissmann Stephen J. Jenkins
author_facet	Calum C. Bain Catherine A. Hawley Hannah Garner Charlotte L. Scott Anika Schridde Nicholas J. Steers Matthias Mack Anagha Joshi Martin Guilliams Allan Mc I. Mowat Frederic Geissmann Stephen J. Jenkins
author_sort	Calum C. Bain
title	Long-lived self-renewing bone marrow-derived macrophages displace embryo-derived cells to inhabit adult serous cavities
title_short	Long-lived self-renewing bone marrow-derived macrophages displace embryo-derived cells to inhabit adult serous cavities
title_full	Long-lived self-renewing bone marrow-derived macrophages displace embryo-derived cells to inhabit adult serous cavities
title_fullStr	Long-lived self-renewing bone marrow-derived macrophages displace embryo-derived cells to inhabit adult serous cavities
title_full_unstemmed	Long-lived self-renewing bone marrow-derived macrophages displace embryo-derived cells to inhabit adult serous cavities
title_sort	long-lived self-renewing bone marrow-derived macrophages displace embryo-derived cells to inhabit adult serous cavities
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/320587b30d454079837bd3319d6310c0
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Long-lived self-renewing bone marrow-derived macrophages displace embryo-derived cells to inhabit adult serous cavities

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