Mounting, structure and autocleavage of a type VI secretion-associated Rhs polymorphic toxin

Rearrangement hot spots (Rhs) proteins are bacterial polymorphic toxin systems. Here, the authors show that Rhs1 forms a complex with the Type VI secretion system (T6SS) spike protein VgrG and the EagR chaperone. They also present the cryo-EM structure of the Rhs1-EagR complex and propose a model fo...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Dukas Jurėnas, Leonardo Talachia Rosa, Martial Rey, Julia Chamot-Rooke, Rémi Fronzes, Eric Cascales
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3207bbe65e894dab9e6e7124d3c24849
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:3207bbe65e894dab9e6e7124d3c24849
record_format	dspace
spelling	oai:doaj.org-article:3207bbe65e894dab9e6e7124d3c248492021-12-05T12:21:59ZMounting, structure and autocleavage of a type VI secretion-associated Rhs polymorphic toxin10.1038/s41467-021-27388-02041-1723https://doaj.org/article/3207bbe65e894dab9e6e7124d3c248492021-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-27388-0https://doaj.org/toc/2041-1723Rearrangement hot spots (Rhs) proteins are bacterial polymorphic toxin systems. Here, the authors show that Rhs1 forms a complex with the Type VI secretion system (T6SS) spike protein VgrG and the EagR chaperone. They also present the cryo-EM structure of the Rhs1-EagR complex and propose a model for Rhs loading and delivery by the T6SS.Dukas JurėnasLeonardo Talachia RosaMartial ReyJulia Chamot-RookeRémi FronzesEric CascalesNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Dukas Jurėnas Leonardo Talachia Rosa Martial Rey Julia Chamot-Rooke Rémi Fronzes Eric Cascales Mounting, structure and autocleavage of a type VI secretion-associated Rhs polymorphic toxin
description	Rearrangement hot spots (Rhs) proteins are bacterial polymorphic toxin systems. Here, the authors show that Rhs1 forms a complex with the Type VI secretion system (T6SS) spike protein VgrG and the EagR chaperone. They also present the cryo-EM structure of the Rhs1-EagR complex and propose a model for Rhs loading and delivery by the T6SS.
format	article
author	Dukas Jurėnas Leonardo Talachia Rosa Martial Rey Julia Chamot-Rooke Rémi Fronzes Eric Cascales
author_facet	Dukas Jurėnas Leonardo Talachia Rosa Martial Rey Julia Chamot-Rooke Rémi Fronzes Eric Cascales
author_sort	Dukas Jurėnas
title	Mounting, structure and autocleavage of a type VI secretion-associated Rhs polymorphic toxin
title_short	Mounting, structure and autocleavage of a type VI secretion-associated Rhs polymorphic toxin
title_full	Mounting, structure and autocleavage of a type VI secretion-associated Rhs polymorphic toxin
title_fullStr	Mounting, structure and autocleavage of a type VI secretion-associated Rhs polymorphic toxin
title_full_unstemmed	Mounting, structure and autocleavage of a type VI secretion-associated Rhs polymorphic toxin
title_sort	mounting, structure and autocleavage of a type vi secretion-associated rhs polymorphic toxin
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/3207bbe65e894dab9e6e7124d3c24849
work_keys_str_mv	AT dukasjurenas mountingstructureandautocleavageofatypevisecretionassociatedrhspolymorphictoxin AT leonardotalachiarosa mountingstructureandautocleavageofatypevisecretionassociatedrhspolymorphictoxin AT martialrey mountingstructureandautocleavageofatypevisecretionassociatedrhspolymorphictoxin AT juliachamotrooke mountingstructureandautocleavageofatypevisecretionassociatedrhspolymorphictoxin AT remifronzes mountingstructureandautocleavageofatypevisecretionassociatedrhspolymorphictoxin AT ericcascales mountingstructureandautocleavageofatypevisecretionassociatedrhspolymorphictoxin
_version_	1718372007901396992

Mounting, structure and autocleavage of a type VI secretion-associated Rhs polymorphic toxin

Ejemplares similares