Small molecule antagonists of the Wnt/β-catenin signaling pathway target breast tumor-initiating cells in a Her2/Neu mouse model of breast cancer.

Small molecule antagonists of the Wnt/β-catenin signaling pathway target breast tumor-initiating cells in a Her2/Neu mouse model of breast cancer.

<h4>Background</h4>Recent evidence suggests that human breast cancer is sustained by a minor subpopulation of breast tumor-initiating cells (BTIC), which confer resistance to anticancer therapies and consequently must be eradicated to achieve durable breast cancer cure.<h4>Methods/...

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Autores principales: Robin M Hallett, Maria K Kondratyev, Andrew O Giacomelli, Allison M L Nixon, Adele Girgis-Gabardo, Dora Ilieva, John A Hassell
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2012
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Medicine
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Science
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Acceso en línea:https://doaj.org/article/320b586707fa4ac99d9f32083da7021b
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