Endothelial function in men with type 2 diabetes without clinical signs of cardiovascular disease

Type 2 diabetes mellitus (T2DM) increases the risk of cardiovascular disease that is based on endothelial dysfunction (ED). Currently, conventional diagnostic methods are unreliable, especially at early stages of disease.Aims. The aim of this work was to assess endothelial function in men with T2DM...

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Autores principales:	Irina Alexandrovna Khripun, Sergey Vladislavovich Vorobyev, Maxim Nikolaevich Morgunov, Michail Iosifovich Kogan
Formato:	article
Lenguaje:	EN RU
Publicado:	Endocrinology Research Centre 2016
Materias:	endothelial dysfunction type 2 diabetes mellitus arterial vasoreactivity endothelium-dependent vasodilation early diagnosis Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/320ca4f096034d9dba078b3e970a25eb
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spelling	oai:doaj.org-article:320ca4f096034d9dba078b3e970a25eb2021-11-14T09:00:20ZEndothelial function in men with type 2 diabetes without clinical signs of cardiovascular disease2072-03512072-037810.14341/DM8017https://doaj.org/article/320ca4f096034d9dba078b3e970a25eb2016-11-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/8017https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378Type 2 diabetes mellitus (T2DM) increases the risk of cardiovascular disease that is based on endothelial dysfunction (ED). Currently, conventional diagnostic methods are unreliable, especially at early stages of disease.Aims. The aim of this work was to assess endothelial function in men with T2DM without clinical signs of cardiovascular disease.Materials and methods. The study included 100 patients (mean age, 54.3 ± 5.3 years) with a T2DM duration of less than 10 years and without signs of cardiovascular disease. The patients were divided into two groups: group 1 consisted of 60 patients with a T2DM duration of less than five years. Group 2 included 40 men with a history of diabetes between 5 and 10 years. Endothelial function was assessed by the levels of nitric oxide (NO), endothelial NO synthase type 3 (eNOS3), ICAM-1, VCAM-1, E-selectin, P-selectin, resistin and C-reactive protein and the arterial vasoreactivity of the brachial artery (BA) using the D. Celermajer method.Results. Results revealed decreases in levels of both eNOS3 by 2.5 fold (P = 0.0005) and NO by 1.9 fold (P = 0.043) in group 2 patients, compared to those in group 1 patients. When the duration of diabetes was greater than five years, levels of VCAM-1, resistin and C-reactive protein increased by 12.1% (P = 0.048), 62% (P = 0.01) and 45.6%, respectively. Additionally, the time until maximal BA vasodilatation during reactive hyperemia was observed to be higher in group 2 [105 (90; 180) seconds] than those in group 1 [90 (60; 120) seconds].Conclusions. Biochemical and imaging signs of ED begin to appear in the first five years of T2DM, long before clinical manifestations. The earliest symptoms are decreases in eNOS3 and NO levels, increases in VCAM-1 and resistin concentrations and increased time until maximal BA vasodilatation during reactive hyperemia.Irina Alexandrovna KhripunSergey Vladislavovich VorobyevMaxim Nikolaevich MorgunovMichail Iosifovich KoganEndocrinology Research Centrearticleendothelial dysfunctiontype 2 diabetes mellitusarterial vasoreactivityendothelium-dependent vasodilationearly diagnosisNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 19, Iss 5, Pp 383-387 (2016)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	endothelial dysfunction type 2 diabetes mellitus arterial vasoreactivity endothelium-dependent vasodilation early diagnosis Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	endothelial dysfunction type 2 diabetes mellitus arterial vasoreactivity endothelium-dependent vasodilation early diagnosis Nutritional diseases. Deficiency diseases RC620-627 Irina Alexandrovna Khripun Sergey Vladislavovich Vorobyev Maxim Nikolaevich Morgunov Michail Iosifovich Kogan Endothelial function in men with type 2 diabetes without clinical signs of cardiovascular disease
description	Type 2 diabetes mellitus (T2DM) increases the risk of cardiovascular disease that is based on endothelial dysfunction (ED). Currently, conventional diagnostic methods are unreliable, especially at early stages of disease.Aims. The aim of this work was to assess endothelial function in men with T2DM without clinical signs of cardiovascular disease.Materials and methods. The study included 100 patients (mean age, 54.3 ± 5.3 years) with a T2DM duration of less than 10 years and without signs of cardiovascular disease. The patients were divided into two groups: group 1 consisted of 60 patients with a T2DM duration of less than five years. Group 2 included 40 men with a history of diabetes between 5 and 10 years. Endothelial function was assessed by the levels of nitric oxide (NO), endothelial NO synthase type 3 (eNOS3), ICAM-1, VCAM-1, E-selectin, P-selectin, resistin and C-reactive protein and the arterial vasoreactivity of the brachial artery (BA) using the D. Celermajer method.Results. Results revealed decreases in levels of both eNOS3 by 2.5 fold (P = 0.0005) and NO by 1.9 fold (P = 0.043) in group 2 patients, compared to those in group 1 patients. When the duration of diabetes was greater than five years, levels of VCAM-1, resistin and C-reactive protein increased by 12.1% (P = 0.048), 62% (P = 0.01) and 45.6%, respectively. Additionally, the time until maximal BA vasodilatation during reactive hyperemia was observed to be higher in group 2 [105 (90; 180) seconds] than those in group 1 [90 (60; 120) seconds].Conclusions. Biochemical and imaging signs of ED begin to appear in the first five years of T2DM, long before clinical manifestations. The earliest symptoms are decreases in eNOS3 and NO levels, increases in VCAM-1 and resistin concentrations and increased time until maximal BA vasodilatation during reactive hyperemia.
format	article
author	Irina Alexandrovna Khripun Sergey Vladislavovich Vorobyev Maxim Nikolaevich Morgunov Michail Iosifovich Kogan
author_facet	Irina Alexandrovna Khripun Sergey Vladislavovich Vorobyev Maxim Nikolaevich Morgunov Michail Iosifovich Kogan
author_sort	Irina Alexandrovna Khripun
title	Endothelial function in men with type 2 diabetes without clinical signs of cardiovascular disease
title_short	Endothelial function in men with type 2 diabetes without clinical signs of cardiovascular disease
title_full	Endothelial function in men with type 2 diabetes without clinical signs of cardiovascular disease
title_fullStr	Endothelial function in men with type 2 diabetes without clinical signs of cardiovascular disease
title_full_unstemmed	Endothelial function in men with type 2 diabetes without clinical signs of cardiovascular disease
title_sort	endothelial function in men with type 2 diabetes without clinical signs of cardiovascular disease
publisher	Endocrinology Research Centre
publishDate	2016
url	https://doaj.org/article/320ca4f096034d9dba078b3e970a25eb
work_keys_str_mv	AT irinaalexandrovnakhripun endothelialfunctioninmenwithtype2diabeteswithoutclinicalsignsofcardiovasculardisease AT sergeyvladislavovichvorobyev endothelialfunctioninmenwithtype2diabeteswithoutclinicalsignsofcardiovasculardisease AT maximnikolaevichmorgunov endothelialfunctioninmenwithtype2diabeteswithoutclinicalsignsofcardiovasculardisease AT michailiosifovichkogan endothelialfunctioninmenwithtype2diabeteswithoutclinicalsignsofcardiovasculardisease
_version_	1718429516203819008

Endothelial function in men with type 2 diabetes without clinical signs of cardiovascular disease

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