Urothelial organoids originating from Cd49fhigh mouse stem cells display Notch-dependent differentiation capacity

The biology of the urothelium has been difficult to study given the lack of methods to propagate these cells. Here, the authors generate mouse urothelial organoids derived from bladder urothelial cells with high CD49f/ITGA6 and define what regulates urothelium differentiation, which is PPARγ, EGFR a...

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Auteurs principaux:	Catarina P. Santos, Eleonora Lapi, Jaime Martínez de Villarreal, Laura Álvaro-Espinosa, Asunción Fernández-Barral, Antonio Barbáchano, Orlando Domínguez, Ashley M. Laughney, Diego Megías, Alberto Muñoz, Francisco X. Real
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2019
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/320d107785b94de1b92b9124a3eed2a2
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spelling	oai:doaj.org-article:320d107785b94de1b92b9124a3eed2a22021-12-02T15:35:30ZUrothelial organoids originating from Cd49fhigh mouse stem cells display Notch-dependent differentiation capacity10.1038/s41467-019-12307-12041-1723https://doaj.org/article/320d107785b94de1b92b9124a3eed2a22019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12307-1https://doaj.org/toc/2041-1723The biology of the urothelium has been difficult to study given the lack of methods to propagate these cells. Here, the authors generate mouse urothelial organoids derived from bladder urothelial cells with high CD49f/ITGA6 and define what regulates urothelium differentiation, which is PPARγ, EGFR and Notch signalling.Catarina P. SantosEleonora LapiJaime Martínez de VillarrealLaura Álvaro-EspinosaAsunción Fernández-BarralAntonio BarbáchanoOrlando DomínguezAshley M. LaughneyDiego MegíasAlberto MuñozFrancisco X. RealNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Catarina P. Santos Eleonora Lapi Jaime Martínez de Villarreal Laura Álvaro-Espinosa Asunción Fernández-Barral Antonio Barbáchano Orlando Domínguez Ashley M. Laughney Diego Megías Alberto Muñoz Francisco X. Real Urothelial organoids originating from Cd49fhigh mouse stem cells display Notch-dependent differentiation capacity
description	The biology of the urothelium has been difficult to study given the lack of methods to propagate these cells. Here, the authors generate mouse urothelial organoids derived from bladder urothelial cells with high CD49f/ITGA6 and define what regulates urothelium differentiation, which is PPARγ, EGFR and Notch signalling.
format	article
author	Catarina P. Santos Eleonora Lapi Jaime Martínez de Villarreal Laura Álvaro-Espinosa Asunción Fernández-Barral Antonio Barbáchano Orlando Domínguez Ashley M. Laughney Diego Megías Alberto Muñoz Francisco X. Real
author_facet	Catarina P. Santos Eleonora Lapi Jaime Martínez de Villarreal Laura Álvaro-Espinosa Asunción Fernández-Barral Antonio Barbáchano Orlando Domínguez Ashley M. Laughney Diego Megías Alberto Muñoz Francisco X. Real
author_sort	Catarina P. Santos
title	Urothelial organoids originating from Cd49fhigh mouse stem cells display Notch-dependent differentiation capacity
title_short	Urothelial organoids originating from Cd49fhigh mouse stem cells display Notch-dependent differentiation capacity
title_full	Urothelial organoids originating from Cd49fhigh mouse stem cells display Notch-dependent differentiation capacity
title_fullStr	Urothelial organoids originating from Cd49fhigh mouse stem cells display Notch-dependent differentiation capacity
title_full_unstemmed	Urothelial organoids originating from Cd49fhigh mouse stem cells display Notch-dependent differentiation capacity
title_sort	urothelial organoids originating from cd49fhigh mouse stem cells display notch-dependent differentiation capacity
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/320d107785b94de1b92b9124a3eed2a2
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Urothelial organoids originating from Cd49fhigh mouse stem cells display Notch-dependent differentiation capacity

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