Analysis of the Role of Neurospecific Proteins in the Diagnosis of Cognitive Dysfunction in Patients with Type 1 Diabetes Mellitus

Background. Impairment of the central nervous system manifested as cognitive dysfunction caused by metabolic or structural changes is a severe progressive vascular complication of type 1 diabetes mellitus (T1DM). Significant difficulties in the diagnosis of cognitive dysfunction are associated with...

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Autores principales:	Yulia Gennad'evna Samoylova, Maria Vladimirovna Novoselova, Natalya Grigor'evna Zhukova, Olga Sergeevna Tonkikh
Formato:	article
Lenguaje:	EN RU
Publicado:	Endocrinology Research Centre 2014
Materias:	type 1 diabetes mellitus cognitive dysfunction neurospecific proteins magnetic resonance imaging Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/320f66bab6dc47af86966d6336427634
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spelling	oai:doaj.org-article:320f66bab6dc47af86966d63364276342021-11-14T09:00:19ZAnalysis of the Role of Neurospecific Proteins in the Diagnosis of Cognitive Dysfunction in Patients with Type 1 Diabetes Mellitus2072-03512072-037810.14341/DM2014283-90https://doaj.org/article/320f66bab6dc47af86966d63364276342014-07-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/6339https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378Background. Impairment of the central nervous system manifested as cognitive dysfunction caused by metabolic or structural changes is a severe progressive vascular complication of type 1 diabetes mellitus (T1DM). Significant difficulties in the diagnosis of cognitive dysfunction are associated with subjective diagnostic techniques. Objective. To identify the role of neurospecific markers in the diagnosis of cognitive dysfunction in patients with T1DM. Materials and Methods. A total of 58 patients with T1DM aged 16?30 years were included in this study. The control group included 29 healthy young adults matched by gender and age. The survey included clinical and laboratory examinations, psychological testing and magnetic resonance imaging (MRI) of the brain. The Montreal Cognitive Assessment (MoCA) was used to screen for cognitive impairment. The levels of neurospecific proteins (S100, glial fibrillary acidic protein and myelin basic protein) were determined to identify early markers of cognitive impairment. MRI of the brain was performed using a Siemens Magnetom 1.0 T system to assess structural changes in the central nervous system. Results. The study revealed increased levels of all neurospecific proteins, which correlated with parameters of hyperglycaemia and cognitive deficit (MoCA scores ofYulia Gennad'evna SamoylovaMaria Vladimirovna NovoselovaNatalya Grigor'evna ZhukovaOlga Sergeevna TonkikhEndocrinology Research Centrearticletype 1 diabetes mellituscognitive dysfunctionneurospecific proteinsmagnetic resonance imagingNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 17, Iss 2, Pp 83-90 (2014)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	type 1 diabetes mellitus cognitive dysfunction neurospecific proteins magnetic resonance imaging Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	type 1 diabetes mellitus cognitive dysfunction neurospecific proteins magnetic resonance imaging Nutritional diseases. Deficiency diseases RC620-627 Yulia Gennad'evna Samoylova Maria Vladimirovna Novoselova Natalya Grigor'evna Zhukova Olga Sergeevna Tonkikh Analysis of the Role of Neurospecific Proteins in the Diagnosis of Cognitive Dysfunction in Patients with Type 1 Diabetes Mellitus
description	Background. Impairment of the central nervous system manifested as cognitive dysfunction caused by metabolic or structural changes is a severe progressive vascular complication of type 1 diabetes mellitus (T1DM). Significant difficulties in the diagnosis of cognitive dysfunction are associated with subjective diagnostic techniques. Objective. To identify the role of neurospecific markers in the diagnosis of cognitive dysfunction in patients with T1DM. Materials and Methods. A total of 58 patients with T1DM aged 16?30 years were included in this study. The control group included 29 healthy young adults matched by gender and age. The survey included clinical and laboratory examinations, psychological testing and magnetic resonance imaging (MRI) of the brain. The Montreal Cognitive Assessment (MoCA) was used to screen for cognitive impairment. The levels of neurospecific proteins (S100, glial fibrillary acidic protein and myelin basic protein) were determined to identify early markers of cognitive impairment. MRI of the brain was performed using a Siemens Magnetom 1.0 T system to assess structural changes in the central nervous system. Results. The study revealed increased levels of all neurospecific proteins, which correlated with parameters of hyperglycaemia and cognitive deficit (MoCA scores of
format	article
author	Yulia Gennad'evna Samoylova Maria Vladimirovna Novoselova Natalya Grigor'evna Zhukova Olga Sergeevna Tonkikh
author_facet	Yulia Gennad'evna Samoylova Maria Vladimirovna Novoselova Natalya Grigor'evna Zhukova Olga Sergeevna Tonkikh
author_sort	Yulia Gennad'evna Samoylova
title	Analysis of the Role of Neurospecific Proteins in the Diagnosis of Cognitive Dysfunction in Patients with Type 1 Diabetes Mellitus
title_short	Analysis of the Role of Neurospecific Proteins in the Diagnosis of Cognitive Dysfunction in Patients with Type 1 Diabetes Mellitus
title_full	Analysis of the Role of Neurospecific Proteins in the Diagnosis of Cognitive Dysfunction in Patients with Type 1 Diabetes Mellitus
title_fullStr	Analysis of the Role of Neurospecific Proteins in the Diagnosis of Cognitive Dysfunction in Patients with Type 1 Diabetes Mellitus
title_full_unstemmed	Analysis of the Role of Neurospecific Proteins in the Diagnosis of Cognitive Dysfunction in Patients with Type 1 Diabetes Mellitus
title_sort	analysis of the role of neurospecific proteins in the diagnosis of cognitive dysfunction in patients with type 1 diabetes mellitus
publisher	Endocrinology Research Centre
publishDate	2014
url	https://doaj.org/article/320f66bab6dc47af86966d6336427634
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Analysis of the Role of Neurospecific Proteins in the Diagnosis of Cognitive Dysfunction in Patients with Type 1 Diabetes Mellitus

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