Endoscopic resection is a suitable initial treatment strategy for oxyntic gland adenoma or gastric adenocarcinoma of the fundic gland type

Abstract The aim of this study was to reveal the histological features of oxyntic gland adenomas and gastric adenocarcinoma of the fundic-gland type (GA-FG). We retrospectively examined the histological features of 126 lesions of oxyntic gland adenoma and/or GA-FG in 116 patients. The prevalence of...

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Autores principales:	Masaya Iwamuro, Chiaki Kusumoto, Masahiro Nakagawa, Sayo Kobayashi, Masao Yoshioka, Tomoki Inaba, Tatsuya Toyokawa, Shinichiro Hori, Shouichi Tanaka, Kazuhiro Matsueda, Takehiro Tanaka, Hiroyuki Okada
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/321102c7f12d4392bf3d87a5966c0eb4
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spelling	oai:doaj.org-article:321102c7f12d4392bf3d87a5966c0eb42021-12-02T14:23:14ZEndoscopic resection is a suitable initial treatment strategy for oxyntic gland adenoma or gastric adenocarcinoma of the fundic gland type10.1038/s41598-021-86893-w2045-2322https://doaj.org/article/321102c7f12d4392bf3d87a5966c0eb42021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-86893-whttps://doaj.org/toc/2045-2322Abstract The aim of this study was to reveal the histological features of oxyntic gland adenomas and gastric adenocarcinoma of the fundic-gland type (GA-FG). We retrospectively examined the histological features of 126 lesions of oxyntic gland adenoma and/or GA-FG in 116 patients. The prevalence of oxyntic gland adenomas and GA-FG was approximately equal. The majority of the lesions were resected by endoscopic mucosal resection using a diathermic snare (EMR, n = 42) or endoscopic submucosal dissection (ESD, n = 72). Histologically, there were no lesions with invasion at the level of the muscularis propria or deeper, and lymphovascular invasion was present in 1.6%. Of the ESD and EMR specimens, there were no lesions that were positive for vertical margins. Among the eight GA-FG patients with deep (≥ 500 μm) submucosal invasion, six were treated with endoscopic resection alone, and no recurrence was documented. No patients died of the disease during the median follow-up period of 14.5 months. In conclusion, all lesions were confined to the mucosa or submucosa and were negative for vertical margins. Lymphovascular invasion was present in only 1.6% of the patients. Thus, we believe that endoscopic resection is a suitable initial treatment method for oxyntic gland adenoma and GA-FG.Masaya IwamuroChiaki KusumotoMasahiro NakagawaSayo KobayashiMasao YoshiokaTomoki InabaTatsuya ToyokawaShinichiro HoriShouichi TanakaKazuhiro MatsuedaTakehiro TanakaHiroyuki OkadaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Masaya Iwamuro Chiaki Kusumoto Masahiro Nakagawa Sayo Kobayashi Masao Yoshioka Tomoki Inaba Tatsuya Toyokawa Shinichiro Hori Shouichi Tanaka Kazuhiro Matsueda Takehiro Tanaka Hiroyuki Okada Endoscopic resection is a suitable initial treatment strategy for oxyntic gland adenoma or gastric adenocarcinoma of the fundic gland type
description	Abstract The aim of this study was to reveal the histological features of oxyntic gland adenomas and gastric adenocarcinoma of the fundic-gland type (GA-FG). We retrospectively examined the histological features of 126 lesions of oxyntic gland adenoma and/or GA-FG in 116 patients. The prevalence of oxyntic gland adenomas and GA-FG was approximately equal. The majority of the lesions were resected by endoscopic mucosal resection using a diathermic snare (EMR, n = 42) or endoscopic submucosal dissection (ESD, n = 72). Histologically, there were no lesions with invasion at the level of the muscularis propria or deeper, and lymphovascular invasion was present in 1.6%. Of the ESD and EMR specimens, there were no lesions that were positive for vertical margins. Among the eight GA-FG patients with deep (≥ 500 μm) submucosal invasion, six were treated with endoscopic resection alone, and no recurrence was documented. No patients died of the disease during the median follow-up period of 14.5 months. In conclusion, all lesions were confined to the mucosa or submucosa and were negative for vertical margins. Lymphovascular invasion was present in only 1.6% of the patients. Thus, we believe that endoscopic resection is a suitable initial treatment method for oxyntic gland adenoma and GA-FG.
format	article
author	Masaya Iwamuro Chiaki Kusumoto Masahiro Nakagawa Sayo Kobayashi Masao Yoshioka Tomoki Inaba Tatsuya Toyokawa Shinichiro Hori Shouichi Tanaka Kazuhiro Matsueda Takehiro Tanaka Hiroyuki Okada
author_facet	Masaya Iwamuro Chiaki Kusumoto Masahiro Nakagawa Sayo Kobayashi Masao Yoshioka Tomoki Inaba Tatsuya Toyokawa Shinichiro Hori Shouichi Tanaka Kazuhiro Matsueda Takehiro Tanaka Hiroyuki Okada
author_sort	Masaya Iwamuro
title	Endoscopic resection is a suitable initial treatment strategy for oxyntic gland adenoma or gastric adenocarcinoma of the fundic gland type
title_short	Endoscopic resection is a suitable initial treatment strategy for oxyntic gland adenoma or gastric adenocarcinoma of the fundic gland type
title_full	Endoscopic resection is a suitable initial treatment strategy for oxyntic gland adenoma or gastric adenocarcinoma of the fundic gland type
title_fullStr	Endoscopic resection is a suitable initial treatment strategy for oxyntic gland adenoma or gastric adenocarcinoma of the fundic gland type
title_full_unstemmed	Endoscopic resection is a suitable initial treatment strategy for oxyntic gland adenoma or gastric adenocarcinoma of the fundic gland type
title_sort	endoscopic resection is a suitable initial treatment strategy for oxyntic gland adenoma or gastric adenocarcinoma of the fundic gland type
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/321102c7f12d4392bf3d87a5966c0eb4
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Endoscopic resection is a suitable initial treatment strategy for oxyntic gland adenoma or gastric adenocarcinoma of the fundic gland type

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