Unknown Risk on the Farm: Does Agricultural Use of Ionophores Contribute to the Burden of Antimicrobial Resistance?

ABSTRACT Ionophores are the second most widely used class of antibiotic in agriculture, with over 4 million kilograms sold in the United States in 2016. Because ionophores are not used in humans, it is widely assumed that their agricultural use will not impact human health. Consequently, these drugs...

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Autor principal:	Alex Wong
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2019
Materias:	ionophore cross-resistance coselection veterinary microbiology agriculture monensin Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/32136294e60a4c20906af6a19c51d719
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spelling	oai:doaj.org-article:32136294e60a4c20906af6a19c51d7192021-11-15T15:27:33ZUnknown Risk on the Farm: Does Agricultural Use of Ionophores Contribute to the Burden of Antimicrobial Resistance?10.1128/mSphere.00433-192379-5042https://doaj.org/article/32136294e60a4c20906af6a19c51d7192019-10-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mSphere.00433-19https://doaj.org/toc/2379-5042ABSTRACT Ionophores are the second most widely used class of antibiotic in agriculture, with over 4 million kilograms sold in the United States in 2016. Because ionophores are not used in humans, it is widely assumed that their agricultural use will not impact human health. Consequently, these drugs have not been subject to the same regulations as medically important antibiotics. Here, I argue that the current evidence base is insufficient to conclude that ionophores do not contribute to human relevant antimicrobial resistance. It is unclear whether ionophore resistance can result in cross-resistance to medically important antibiotics. Moreover, recent evidence suggests that ionophore use may coselect for resistance to vancomycin in some cases. Systematic investigation of the consequences of agricultural ionophore use for human health is therefore imperative.Alex WongAmerican Society for Microbiologyarticleionophorecross-resistancecoselectionveterinary microbiologyagriculturemonensinMicrobiologyQR1-502ENmSphere, Vol 4, Iss 5 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	ionophore cross-resistance coselection veterinary microbiology agriculture monensin Microbiology QR1-502
spellingShingle	ionophore cross-resistance coselection veterinary microbiology agriculture monensin Microbiology QR1-502 Alex Wong Unknown Risk on the Farm: Does Agricultural Use of Ionophores Contribute to the Burden of Antimicrobial Resistance?
description	ABSTRACT Ionophores are the second most widely used class of antibiotic in agriculture, with over 4 million kilograms sold in the United States in 2016. Because ionophores are not used in humans, it is widely assumed that their agricultural use will not impact human health. Consequently, these drugs have not been subject to the same regulations as medically important antibiotics. Here, I argue that the current evidence base is insufficient to conclude that ionophores do not contribute to human relevant antimicrobial resistance. It is unclear whether ionophore resistance can result in cross-resistance to medically important antibiotics. Moreover, recent evidence suggests that ionophore use may coselect for resistance to vancomycin in some cases. Systematic investigation of the consequences of agricultural ionophore use for human health is therefore imperative.
format	article
author	Alex Wong
author_facet	Alex Wong
author_sort	Alex Wong
title	Unknown Risk on the Farm: Does Agricultural Use of Ionophores Contribute to the Burden of Antimicrobial Resistance?
title_short	Unknown Risk on the Farm: Does Agricultural Use of Ionophores Contribute to the Burden of Antimicrobial Resistance?
title_full	Unknown Risk on the Farm: Does Agricultural Use of Ionophores Contribute to the Burden of Antimicrobial Resistance?
title_fullStr	Unknown Risk on the Farm: Does Agricultural Use of Ionophores Contribute to the Burden of Antimicrobial Resistance?
title_full_unstemmed	Unknown Risk on the Farm: Does Agricultural Use of Ionophores Contribute to the Burden of Antimicrobial Resistance?
title_sort	unknown risk on the farm: does agricultural use of ionophores contribute to the burden of antimicrobial resistance?
publisher	American Society for Microbiology
publishDate	2019
url	https://doaj.org/article/32136294e60a4c20906af6a19c51d719
work_keys_str_mv	AT alexwong unknownriskonthefarmdoesagriculturaluseofionophorescontributetotheburdenofantimicrobialresistance
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Unknown Risk on the Farm: Does Agricultural Use of Ionophores Contribute to the Burden of Antimicrobial Resistance?

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