ARID1A promotes genomic stability through protecting telomere cohesion

ARID1A promotes genomic stability through protecting telomere cohesion

Cells with ARID1A mutations exhibit mitotic defects, yet show surprisingly low levels of copy number defects. Here, Zhao et al. resolve this issue by showing that ARID1A loss causes defects in telomere cohesion, which selects against gross alterations in copy number.

Guardado en:
Detalles Bibliográficos
Autores principales: Bo Zhao, Jianhuang Lin, Lijie Rong, Shuai Wu, Zhong Deng, Nail Fatkhutdinov, Joseph Zundell, Takeshi Fukumoto, Qin Liu, Andrew Kossenkov, Stephanie Jean, Mark G. Cadungog, Mark E. Borowsky, Ronny Drapkin, Paul M. Lieberman, Cory T. Abate-Shen, Rugang Zhang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/3213993b084647d5b37ab0de3d259d0b
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
Descripción
Sumario:Cells with ARID1A mutations exhibit mitotic defects, yet show surprisingly low levels of copy number defects. Here, Zhao et al. resolve this issue by showing that ARID1A loss causes defects in telomere cohesion, which selects against gross alterations in copy number.

Ejemplares similares