ARID1A promotes genomic stability through protecting telomere cohesion

Cells with ARID1A mutations exhibit mitotic defects, yet show surprisingly low levels of copy number defects. Here, Zhao et al. resolve this issue by showing that ARID1A loss causes defects in telomere cohesion, which selects against gross alterations in copy number.

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Autores principales:	Bo Zhao, Jianhuang Lin, Lijie Rong, Shuai Wu, Zhong Deng, Nail Fatkhutdinov, Joseph Zundell, Takeshi Fukumoto, Qin Liu, Andrew Kossenkov, Stephanie Jean, Mark G. Cadungog, Mark E. Borowsky, Ronny Drapkin, Paul M. Lieberman, Cory T. Abate-Shen, Rugang Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3213993b084647d5b37ab0de3d259d0b
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spelling	oai:doaj.org-article:3213993b084647d5b37ab0de3d259d0b2021-12-02T16:57:06ZARID1A promotes genomic stability through protecting telomere cohesion10.1038/s41467-019-12037-42041-1723https://doaj.org/article/3213993b084647d5b37ab0de3d259d0b2019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12037-4https://doaj.org/toc/2041-1723Cells with ARID1A mutations exhibit mitotic defects, yet show surprisingly low levels of copy number defects. Here, Zhao et al. resolve this issue by showing that ARID1A loss causes defects in telomere cohesion, which selects against gross alterations in copy number.Bo ZhaoJianhuang LinLijie RongShuai WuZhong DengNail FatkhutdinovJoseph ZundellTakeshi FukumotoQin LiuAndrew KossenkovStephanie JeanMark G. CadungogMark E. BorowskyRonny DrapkinPaul M. LiebermanCory T. Abate-ShenRugang ZhangNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Bo Zhao Jianhuang Lin Lijie Rong Shuai Wu Zhong Deng Nail Fatkhutdinov Joseph Zundell Takeshi Fukumoto Qin Liu Andrew Kossenkov Stephanie Jean Mark G. Cadungog Mark E. Borowsky Ronny Drapkin Paul M. Lieberman Cory T. Abate-Shen Rugang Zhang ARID1A promotes genomic stability through protecting telomere cohesion
description	Cells with ARID1A mutations exhibit mitotic defects, yet show surprisingly low levels of copy number defects. Here, Zhao et al. resolve this issue by showing that ARID1A loss causes defects in telomere cohesion, which selects against gross alterations in copy number.
format	article
author	Bo Zhao Jianhuang Lin Lijie Rong Shuai Wu Zhong Deng Nail Fatkhutdinov Joseph Zundell Takeshi Fukumoto Qin Liu Andrew Kossenkov Stephanie Jean Mark G. Cadungog Mark E. Borowsky Ronny Drapkin Paul M. Lieberman Cory T. Abate-Shen Rugang Zhang
author_facet	Bo Zhao Jianhuang Lin Lijie Rong Shuai Wu Zhong Deng Nail Fatkhutdinov Joseph Zundell Takeshi Fukumoto Qin Liu Andrew Kossenkov Stephanie Jean Mark G. Cadungog Mark E. Borowsky Ronny Drapkin Paul M. Lieberman Cory T. Abate-Shen Rugang Zhang
author_sort	Bo Zhao
title	ARID1A promotes genomic stability through protecting telomere cohesion
title_short	ARID1A promotes genomic stability through protecting telomere cohesion
title_full	ARID1A promotes genomic stability through protecting telomere cohesion
title_fullStr	ARID1A promotes genomic stability through protecting telomere cohesion
title_full_unstemmed	ARID1A promotes genomic stability through protecting telomere cohesion
title_sort	arid1a promotes genomic stability through protecting telomere cohesion
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/3213993b084647d5b37ab0de3d259d0b
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_version_	1718382615865589760

ARID1A promotes genomic stability through protecting telomere cohesion

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