A systems biology approach towards understanding and treating non-neovascular age-related macular degeneration

No effective therapies exist for dry age-related macular degeneration. In this perspective, the authors propose that research should emphasize system biology approaches that integrate various ‘omics’ data into mathematical models to establish pathogenic mechanisms on which to design novel treatments...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	James T. Handa, Cathy Bowes Rickman, Andrew D. Dick, Michael B. Gorin, Joan W. Miller, Cynthia A. Toth, Marius Ueffing, Marco Zarbin, Lindsay A. Farrer
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3214b0dbb9844fa984ecd1315c89c90d
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:3214b0dbb9844fa984ecd1315c89c90d
record_format	dspace
spelling	oai:doaj.org-article:3214b0dbb9844fa984ecd1315c89c90d2021-12-02T16:57:09ZA systems biology approach towards understanding and treating non-neovascular age-related macular degeneration10.1038/s41467-019-11262-12041-1723https://doaj.org/article/3214b0dbb9844fa984ecd1315c89c90d2019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11262-1https://doaj.org/toc/2041-1723No effective therapies exist for dry age-related macular degeneration. In this perspective, the authors propose that research should emphasize system biology approaches that integrate various ‘omics’ data into mathematical models to establish pathogenic mechanisms on which to design novel treatments, and identify biomarkers that predict disease progression and therapeutic response.James T. HandaCathy Bowes RickmanAndrew D. DickMichael B. GorinJoan W. MillerCynthia A. TothMarius UeffingMarco ZarbinLindsay A. FarrerNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q James T. Handa Cathy Bowes Rickman Andrew D. Dick Michael B. Gorin Joan W. Miller Cynthia A. Toth Marius Ueffing Marco Zarbin Lindsay A. Farrer A systems biology approach towards understanding and treating non-neovascular age-related macular degeneration
description	No effective therapies exist for dry age-related macular degeneration. In this perspective, the authors propose that research should emphasize system biology approaches that integrate various ‘omics’ data into mathematical models to establish pathogenic mechanisms on which to design novel treatments, and identify biomarkers that predict disease progression and therapeutic response.
format	article
author	James T. Handa Cathy Bowes Rickman Andrew D. Dick Michael B. Gorin Joan W. Miller Cynthia A. Toth Marius Ueffing Marco Zarbin Lindsay A. Farrer
author_facet	James T. Handa Cathy Bowes Rickman Andrew D. Dick Michael B. Gorin Joan W. Miller Cynthia A. Toth Marius Ueffing Marco Zarbin Lindsay A. Farrer
author_sort	James T. Handa
title	A systems biology approach towards understanding and treating non-neovascular age-related macular degeneration
title_short	A systems biology approach towards understanding and treating non-neovascular age-related macular degeneration
title_full	A systems biology approach towards understanding and treating non-neovascular age-related macular degeneration
title_fullStr	A systems biology approach towards understanding and treating non-neovascular age-related macular degeneration
title_full_unstemmed	A systems biology approach towards understanding and treating non-neovascular age-related macular degeneration
title_sort	systems biology approach towards understanding and treating non-neovascular age-related macular degeneration
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/3214b0dbb9844fa984ecd1315c89c90d
work_keys_str_mv	AT jamesthanda asystemsbiologyapproachtowardsunderstandingandtreatingnonneovascularagerelatedmaculardegeneration AT cathybowesrickman asystemsbiologyapproachtowardsunderstandingandtreatingnonneovascularagerelatedmaculardegeneration AT andrewddick asystemsbiologyapproachtowardsunderstandingandtreatingnonneovascularagerelatedmaculardegeneration AT michaelbgorin asystemsbiologyapproachtowardsunderstandingandtreatingnonneovascularagerelatedmaculardegeneration AT joanwmiller asystemsbiologyapproachtowardsunderstandingandtreatingnonneovascularagerelatedmaculardegeneration AT cynthiaatoth asystemsbiologyapproachtowardsunderstandingandtreatingnonneovascularagerelatedmaculardegeneration AT mariusueffing asystemsbiologyapproachtowardsunderstandingandtreatingnonneovascularagerelatedmaculardegeneration AT marcozarbin asystemsbiologyapproachtowardsunderstandingandtreatingnonneovascularagerelatedmaculardegeneration AT lindsayafarrer asystemsbiologyapproachtowardsunderstandingandtreatingnonneovascularagerelatedmaculardegeneration AT jamesthanda systemsbiologyapproachtowardsunderstandingandtreatingnonneovascularagerelatedmaculardegeneration AT cathybowesrickman systemsbiologyapproachtowardsunderstandingandtreatingnonneovascularagerelatedmaculardegeneration AT andrewddick systemsbiologyapproachtowardsunderstandingandtreatingnonneovascularagerelatedmaculardegeneration AT michaelbgorin systemsbiologyapproachtowardsunderstandingandtreatingnonneovascularagerelatedmaculardegeneration AT joanwmiller systemsbiologyapproachtowardsunderstandingandtreatingnonneovascularagerelatedmaculardegeneration AT cynthiaatoth systemsbiologyapproachtowardsunderstandingandtreatingnonneovascularagerelatedmaculardegeneration AT mariusueffing systemsbiologyapproachtowardsunderstandingandtreatingnonneovascularagerelatedmaculardegeneration AT marcozarbin systemsbiologyapproachtowardsunderstandingandtreatingnonneovascularagerelatedmaculardegeneration AT lindsayafarrer systemsbiologyapproachtowardsunderstandingandtreatingnonneovascularagerelatedmaculardegeneration
_version_	1718382616052236288

A systems biology approach towards understanding and treating non-neovascular age-related macular degeneration

Ejemplares similares