Protective effect of titanium tetrafluoride and silver diamine fluoride on radiation-induced dentin caries in vitro

Abstract This in vitro study evaluated the protective effect of titanium tetrafluoride (TiF4) varnish and silver diamine fluoride (SDF) solution on the radiation-induced dentin caries. Bovine root dentin samples were irradiated (70 Gy) and treated as follows: (6 h): 4% TiF4 varnish; 5.42% NaF varnis...

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Autores principales:	Beatriz Martines de Souza, Mayara Souza Silva, Aline Silva Braga, Patrícia Sanches Kerges Bueno, Paulo Sergio da Silva Santos, Marília Afonso Rabelo Buzalaf, Ana Carolina Magalhães
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3215235927bf471794cd8f785c8b7488
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spelling	oai:doaj.org-article:3215235927bf471794cd8f785c8b74882021-12-02T16:30:24ZProtective effect of titanium tetrafluoride and silver diamine fluoride on radiation-induced dentin caries in vitro10.1038/s41598-021-85748-82045-2322https://doaj.org/article/3215235927bf471794cd8f785c8b74882021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-85748-8https://doaj.org/toc/2045-2322Abstract This in vitro study evaluated the protective effect of titanium tetrafluoride (TiF4) varnish and silver diamine fluoride (SDF) solution on the radiation-induced dentin caries. Bovine root dentin samples were irradiated (70 Gy) and treated as follows: (6 h): 4% TiF4 varnish; 5.42% NaF varnish; 30% SDF solution; placebo varnish; or untreated (negative control). Microcosm biofilm was produced from human dental biofilm (from patients with head-neck cancer) mixed with McBain saliva for the first 8 h. After 16 h and from day 2 to day 5, McBain saliva (0.2% sucrose) was replaced daily (37 °C, 5% CO2) (biological triplicate). Demineralization was quantified by transverse microradiography (TMR), while biofilm was analyzed by using viability, colony-forming units (CFU) counting and lactic acid production assays. The data were statistically analyzed by ANOVA (p < 0.05). TiF4 and SDF were able to reduce mineral loss compared to placebo and the negative control. TiF4 and SDF significantly reduced the biofilm viability compared to negative control. TiF4 significantly reduced the CFU count of total microorganism, while only SDF affected total streptococci and mutans streptococci counts. The varnishes induced a reduction in lactic acid production compared to the negative control. TiF4 and SDF may be good alternatives to control the development of radiation-induced dentin caries.Beatriz Martines de SouzaMayara Souza SilvaAline Silva BragaPatrícia Sanches Kerges BuenoPaulo Sergio da Silva SantosMarília Afonso Rabelo BuzalafAna Carolina MagalhãesNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Beatriz Martines de Souza Mayara Souza Silva Aline Silva Braga Patrícia Sanches Kerges Bueno Paulo Sergio da Silva Santos Marília Afonso Rabelo Buzalaf Ana Carolina Magalhães Protective effect of titanium tetrafluoride and silver diamine fluoride on radiation-induced dentin caries in vitro
description	Abstract This in vitro study evaluated the protective effect of titanium tetrafluoride (TiF4) varnish and silver diamine fluoride (SDF) solution on the radiation-induced dentin caries. Bovine root dentin samples were irradiated (70 Gy) and treated as follows: (6 h): 4% TiF4 varnish; 5.42% NaF varnish; 30% SDF solution; placebo varnish; or untreated (negative control). Microcosm biofilm was produced from human dental biofilm (from patients with head-neck cancer) mixed with McBain saliva for the first 8 h. After 16 h and from day 2 to day 5, McBain saliva (0.2% sucrose) was replaced daily (37 °C, 5% CO2) (biological triplicate). Demineralization was quantified by transverse microradiography (TMR), while biofilm was analyzed by using viability, colony-forming units (CFU) counting and lactic acid production assays. The data were statistically analyzed by ANOVA (p < 0.05). TiF4 and SDF were able to reduce mineral loss compared to placebo and the negative control. TiF4 and SDF significantly reduced the biofilm viability compared to negative control. TiF4 significantly reduced the CFU count of total microorganism, while only SDF affected total streptococci and mutans streptococci counts. The varnishes induced a reduction in lactic acid production compared to the negative control. TiF4 and SDF may be good alternatives to control the development of radiation-induced dentin caries.
format	article
author	Beatriz Martines de Souza Mayara Souza Silva Aline Silva Braga Patrícia Sanches Kerges Bueno Paulo Sergio da Silva Santos Marília Afonso Rabelo Buzalaf Ana Carolina Magalhães
author_facet	Beatriz Martines de Souza Mayara Souza Silva Aline Silva Braga Patrícia Sanches Kerges Bueno Paulo Sergio da Silva Santos Marília Afonso Rabelo Buzalaf Ana Carolina Magalhães
author_sort	Beatriz Martines de Souza
title	Protective effect of titanium tetrafluoride and silver diamine fluoride on radiation-induced dentin caries in vitro
title_short	Protective effect of titanium tetrafluoride and silver diamine fluoride on radiation-induced dentin caries in vitro
title_full	Protective effect of titanium tetrafluoride and silver diamine fluoride on radiation-induced dentin caries in vitro
title_fullStr	Protective effect of titanium tetrafluoride and silver diamine fluoride on radiation-induced dentin caries in vitro
title_full_unstemmed	Protective effect of titanium tetrafluoride and silver diamine fluoride on radiation-induced dentin caries in vitro
title_sort	protective effect of titanium tetrafluoride and silver diamine fluoride on radiation-induced dentin caries in vitro
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/3215235927bf471794cd8f785c8b7488
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Protective effect of titanium tetrafluoride and silver diamine fluoride on radiation-induced dentin caries in vitro

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