Maternal pre-pregnancy body mass index and foetal acidosis in vaginal and caesarean deliveries: The Japan Environment and Children’s Study

Maternal pre-pregnancy body mass index and foetal acidosis in vaginal and caesarean deliveries: The Japan Environment and Children’s Study

Abstract A high maternal body mass index (BMI) is associated with increased risks of asphyxia-related neonatal morbidity. We evaluated the association between maternal pre-pregnancy BMI and foetal acidosis while accounting for the mode of delivery. Participants from the Japan Environment and Childre...

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Autores principales: Tsuyoshi Murata, Hyo Kyozuka, Akiko Yamaguchi, Toma Fukuda, Shun Yasuda, Akiko Sato, Yuka Ogata, Kosei Shinoki, Mitsuaki Hosoya, Seiji Yasumura, Koichi Hashimoto, Hidekazu Nishigori, Keiya Fujimori, The Japan Environment and Children’s Study (JECS) Group
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Medicine
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Science
Q
Acceso en línea:https://doaj.org/article/32173f8ef0df4618b65f69e2f2ba8c19
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spelling oai:doaj.org-article:32173f8ef0df4618b65f69e2f2ba8c192021-12-02T14:28:20ZMaternal pre-pregnancy body mass index and foetal acidosis in vaginal and caesarean deliveries: The Japan Environment and Children’s Study10.1038/s41598-020-79178-12045-2322https://doaj.org/article/32173f8ef0df4618b65f69e2f2ba8c192021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-79178-1https://doaj.org/toc/2045-2322Abstract A high maternal body mass index (BMI) is associated with increased risks of asphyxia-related neonatal morbidity. We evaluated the association between maternal pre-pregnancy BMI and foetal acidosis while accounting for the mode of delivery. Participants from the Japan Environment and Children’s Study with singleton pregnancies after 22 weeks of gestation who gave birth during 2011–2014 were included. The participants (n = 71,799) were categorised into five groups according to the pre-pregnancy BMI: G1 (BMI < 18.5 kg/m2), G2 (18.5 to < 20.0 kg/m2), G3 (20.0 to < 23.0 kg/m2), G4 (23.0 to < 25.0 kg/m2), and G5 (≥ 25.0 kg/m2). Foetal acidosis was defined as umbilical artery pH (UmA-pH) < 7.20 or < 7.10. Multiple logistic regression analyses were used to evaluate the effect of pre-pregnancy BMI on foetal acidosis risk, accounting for the mode of delivery. In Japanese women, pre-pregnancy BMI ≥ 25.0 kg/m2 significantly increased the likelihood of foetal acidosis in newborns delivered vaginally. We found no association between pre-pregnancy BMI and foetal acidosis in newborns delivered via caesarean section. Counselling for body weight control before pregnancy and adequate management and selection of the mode of delivery in pregnant women with a high BMI who are in labour may be essential to avoid foetal acidosis.Tsuyoshi MurataHyo KyozukaAkiko YamaguchiToma FukudaShun YasudaAkiko SatoYuka OgataKosei ShinokiMitsuaki HosoyaSeiji YasumuraKoichi HashimotoHidekazu NishigoriKeiya FujimoriThe Japan Environment and Children’s Study (JECS) GroupNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Tsuyoshi Murata
Hyo Kyozuka
Akiko Yamaguchi
Toma Fukuda
Shun Yasuda
Akiko Sato
Yuka Ogata
Kosei Shinoki
Mitsuaki Hosoya
Seiji Yasumura
Koichi Hashimoto
Hidekazu Nishigori
Keiya Fujimori
The Japan Environment and Children’s Study (JECS) Group
Maternal pre-pregnancy body mass index and foetal acidosis in vaginal and caesarean deliveries: The Japan Environment and Children’s Study
description Abstract A high maternal body mass index (BMI) is associated with increased risks of asphyxia-related neonatal morbidity. We evaluated the association between maternal pre-pregnancy BMI and foetal acidosis while accounting for the mode of delivery. Participants from the Japan Environment and Children’s Study with singleton pregnancies after 22 weeks of gestation who gave birth during 2011–2014 were included. The participants (n = 71,799) were categorised into five groups according to the pre-pregnancy BMI: G1 (BMI < 18.5 kg/m2), G2 (18.5 to < 20.0 kg/m2), G3 (20.0 to < 23.0 kg/m2), G4 (23.0 to < 25.0 kg/m2), and G5 (≥ 25.0 kg/m2). Foetal acidosis was defined as umbilical artery pH (UmA-pH) < 7.20 or < 7.10. Multiple logistic regression analyses were used to evaluate the effect of pre-pregnancy BMI on foetal acidosis risk, accounting for the mode of delivery. In Japanese women, pre-pregnancy BMI ≥ 25.0 kg/m2 significantly increased the likelihood of foetal acidosis in newborns delivered vaginally. We found no association between pre-pregnancy BMI and foetal acidosis in newborns delivered via caesarean section. Counselling for body weight control before pregnancy and adequate management and selection of the mode of delivery in pregnant women with a high BMI who are in labour may be essential to avoid foetal acidosis.
format article
author Tsuyoshi Murata
Hyo Kyozuka
Akiko Yamaguchi
Toma Fukuda
Shun Yasuda
Akiko Sato
Yuka Ogata
Kosei Shinoki
Mitsuaki Hosoya
Seiji Yasumura
Koichi Hashimoto
Hidekazu Nishigori
Keiya Fujimori
The Japan Environment and Children’s Study (JECS) Group
author_facet Tsuyoshi Murata
Hyo Kyozuka
Akiko Yamaguchi
Toma Fukuda
Shun Yasuda
Akiko Sato
Yuka Ogata
Kosei Shinoki
Mitsuaki Hosoya
Seiji Yasumura
Koichi Hashimoto
Hidekazu Nishigori
Keiya Fujimori
The Japan Environment and Children’s Study (JECS) Group
author_sort Tsuyoshi Murata
title Maternal pre-pregnancy body mass index and foetal acidosis in vaginal and caesarean deliveries: The Japan Environment and Children’s Study
title_short Maternal pre-pregnancy body mass index and foetal acidosis in vaginal and caesarean deliveries: The Japan Environment and Children’s Study
title_full Maternal pre-pregnancy body mass index and foetal acidosis in vaginal and caesarean deliveries: The Japan Environment and Children’s Study
title_fullStr Maternal pre-pregnancy body mass index and foetal acidosis in vaginal and caesarean deliveries: The Japan Environment and Children’s Study
title_full_unstemmed Maternal pre-pregnancy body mass index and foetal acidosis in vaginal and caesarean deliveries: The Japan Environment and Children’s Study
title_sort maternal pre-pregnancy body mass index and foetal acidosis in vaginal and caesarean deliveries: the japan environment and children’s study
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/32173f8ef0df4618b65f69e2f2ba8c19
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