<i>Salvia miltiorrhiza</i> Protects Endothelial Dysfunction against Mitochondrial Oxidative Stress

<i>Salvia miltiorrhiza</i> (SM) is a common traditional Chinese medicine used in the treatment of cardiovascular and cerebrovascular diseases. Endothelial dysfunction plays an important role in the pathology of cardiovascular diseases. Endothelial dysfunction may induce inflammation and...

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Autores principales:	Yu-Chen Cheng, I-Ling Hung, Yen-Nung Liao, Wen-Long Hu, Yu-Chiang Hung
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	<i>Salvia miltiorrhiza</i> mitochondria endothelial dysfunction oxidative stress TCM herbal medicine Science Q
Acceso en línea:	https://doaj.org/article/321e864b2a8f43a096c759951debd2d3
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id	oai:doaj.org-article:321e864b2a8f43a096c759951debd2d3
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spelling	oai:doaj.org-article:321e864b2a8f43a096c759951debd2d32021-11-25T18:11:37Z<i>Salvia miltiorrhiza</i> Protects Endothelial Dysfunction against Mitochondrial Oxidative Stress10.3390/life111112572075-1729https://doaj.org/article/321e864b2a8f43a096c759951debd2d32021-11-01T00:00:00Zhttps://www.mdpi.com/2075-1729/11/11/1257https://doaj.org/toc/2075-1729<i>Salvia miltiorrhiza</i> (SM) is a common traditional Chinese medicine used in the treatment of cardiovascular and cerebrovascular diseases. Endothelial dysfunction plays an important role in the pathology of cardiovascular diseases. Endothelial dysfunction may induce inflammation and change vascular tone and permeability. The main pathological mechanism of endothelial dysfunction is the formation of reactive oxygen species (ROS). Mitochondria are the main source of energy and can also produce large amounts of ROS. Recent studies have shown that extracts of SM have antioxidative, anti-inflammatory, and antithrombus properties. In this review, we discuss the mechanism of oxidative stress in the mitochondria, endothelial dysfunction, and the role of SM in these oxidative events.Yu-Chen ChengI-Ling HungYen-Nung LiaoWen-Long HuYu-Chiang HungMDPI AGarticle<i>Salvia miltiorrhiza</i>mitochondriaendothelial dysfunctionoxidative stressTCMherbal medicineScienceQENLife, Vol 11, Iss 1257, p 1257 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	<i>Salvia miltiorrhiza</i> mitochondria endothelial dysfunction oxidative stress TCM herbal medicine Science Q
spellingShingle	<i>Salvia miltiorrhiza</i> mitochondria endothelial dysfunction oxidative stress TCM herbal medicine Science Q Yu-Chen Cheng I-Ling Hung Yen-Nung Liao Wen-Long Hu Yu-Chiang Hung <i>Salvia miltiorrhiza</i> Protects Endothelial Dysfunction against Mitochondrial Oxidative Stress
description	<i>Salvia miltiorrhiza</i> (SM) is a common traditional Chinese medicine used in the treatment of cardiovascular and cerebrovascular diseases. Endothelial dysfunction plays an important role in the pathology of cardiovascular diseases. Endothelial dysfunction may induce inflammation and change vascular tone and permeability. The main pathological mechanism of endothelial dysfunction is the formation of reactive oxygen species (ROS). Mitochondria are the main source of energy and can also produce large amounts of ROS. Recent studies have shown that extracts of SM have antioxidative, anti-inflammatory, and antithrombus properties. In this review, we discuss the mechanism of oxidative stress in the mitochondria, endothelial dysfunction, and the role of SM in these oxidative events.
format	article
author	Yu-Chen Cheng I-Ling Hung Yen-Nung Liao Wen-Long Hu Yu-Chiang Hung
author_facet	Yu-Chen Cheng I-Ling Hung Yen-Nung Liao Wen-Long Hu Yu-Chiang Hung
author_sort	Yu-Chen Cheng
title	<i>Salvia miltiorrhiza</i> Protects Endothelial Dysfunction against Mitochondrial Oxidative Stress
title_short	<i>Salvia miltiorrhiza</i> Protects Endothelial Dysfunction against Mitochondrial Oxidative Stress
title_full	<i>Salvia miltiorrhiza</i> Protects Endothelial Dysfunction against Mitochondrial Oxidative Stress
title_fullStr	<i>Salvia miltiorrhiza</i> Protects Endothelial Dysfunction against Mitochondrial Oxidative Stress
title_full_unstemmed	<i>Salvia miltiorrhiza</i> Protects Endothelial Dysfunction against Mitochondrial Oxidative Stress
title_sort	<i>salvia miltiorrhiza</i> protects endothelial dysfunction against mitochondrial oxidative stress
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/321e864b2a8f43a096c759951debd2d3
work_keys_str_mv	AT yuchencheng isalviamiltiorrhizaiprotectsendothelialdysfunctionagainstmitochondrialoxidativestress AT ilinghung isalviamiltiorrhizaiprotectsendothelialdysfunctionagainstmitochondrialoxidativestress AT yennungliao isalviamiltiorrhizaiprotectsendothelialdysfunctionagainstmitochondrialoxidativestress AT wenlonghu isalviamiltiorrhizaiprotectsendothelialdysfunctionagainstmitochondrialoxidativestress AT yuchianghung isalviamiltiorrhizaiprotectsendothelialdysfunctionagainstmitochondrialoxidativestress
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<i>Salvia miltiorrhiza</i> Protects Endothelial Dysfunction against Mitochondrial Oxidative Stress

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