Bioresponsive cancer-targeted polysaccharide nanosystem to inhibit angiogenesis

Fang Yang, Xueyang Fang, Wenting Jiang, Tianfeng Chen Department of Chemistry, Jinan University, Guangzhou, China Abstract: With many desirable features, such as being more effective and having multiple effects, antiangiogenesis has become one of the promising cancer treatments. The aim of this st...

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Autores principales:	Yang F, Fang XY, Jiang WT, Chen TF
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	polysaccharide nanosystem antiangiogenesis cancer-targeted bioresponsive Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/3222de9c550845e589b30c0cd48c76b8
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spelling	oai:doaj.org-article:3222de9c550845e589b30c0cd48c76b82021-12-02T01:04:03ZBioresponsive cancer-targeted polysaccharide nanosystem to inhibit angiogenesis1178-2013https://doaj.org/article/3222de9c550845e589b30c0cd48c76b82017-10-01T00:00:00Zhttps://www.dovepress.com/bioresponsive-cancer-targeted-polysaccharide-nanosystem-to-inhibit-ang-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Fang Yang, Xueyang Fang, Wenting Jiang, Tianfeng Chen Department of Chemistry, Jinan University, Guangzhou, China Abstract: With many desirable features, such as being more effective and having multiple effects, antiangiogenesis has become one of the promising cancer treatments. The aim of this study was to design and synthesize a new targeted bioresponsive nanosystem with antiangiogenesis properties. The mUPR@Ru(POP) nanosystem was constructed by the polymerization of Ulva lactuca polysaccharide and N-isopropyl acrylamide, decorated with methoxy polyethylene glycol and Arg–Gly–Asp peptide, and encapsulated with anticancer complex [Ru(phen)2p-MOPIP](PF6)2·2H2O. The nanosystem was both pH responsive and targeted. Therefore, the cellular uptake of the drug was greatly improved. Moreover, the mUPR@Ru(POP) had strong suppressive effects against vascular endothelial growth factor (VEGF)-induced angiogenesis through apoptosis. The mUPR@Ru(POP) significantly inhibited VEGF-induced human umbilical vein endothelial cell migration, invasion, and tube formation. These findings have presented new insights into the development of antiangiogenesis drugs. Keywords: polysaccharide nanosystem, antiangiogenesis, cancer-targeted, bioresponsiveYang FFang XYJiang WTChen TFDove Medical Pressarticlepolysaccharide nanosystemantiangiogenesiscancer-targetedbioresponsiveMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 12, Pp 7419-7431 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	polysaccharide nanosystem antiangiogenesis cancer-targeted bioresponsive Medicine (General) R5-920
spellingShingle	polysaccharide nanosystem antiangiogenesis cancer-targeted bioresponsive Medicine (General) R5-920 Yang F Fang XY Jiang WT Chen TF Bioresponsive cancer-targeted polysaccharide nanosystem to inhibit angiogenesis
description	Fang Yang, Xueyang Fang, Wenting Jiang, Tianfeng Chen Department of Chemistry, Jinan University, Guangzhou, China Abstract: With many desirable features, such as being more effective and having multiple effects, antiangiogenesis has become one of the promising cancer treatments. The aim of this study was to design and synthesize a new targeted bioresponsive nanosystem with antiangiogenesis properties. The mUPR@Ru(POP) nanosystem was constructed by the polymerization of Ulva lactuca polysaccharide and N-isopropyl acrylamide, decorated with methoxy polyethylene glycol and Arg–Gly–Asp peptide, and encapsulated with anticancer complex [Ru(phen)2p-MOPIP](PF6)2·2H2O. The nanosystem was both pH responsive and targeted. Therefore, the cellular uptake of the drug was greatly improved. Moreover, the mUPR@Ru(POP) had strong suppressive effects against vascular endothelial growth factor (VEGF)-induced angiogenesis through apoptosis. The mUPR@Ru(POP) significantly inhibited VEGF-induced human umbilical vein endothelial cell migration, invasion, and tube formation. These findings have presented new insights into the development of antiangiogenesis drugs. Keywords: polysaccharide nanosystem, antiangiogenesis, cancer-targeted, bioresponsive
format	article
author	Yang F Fang XY Jiang WT Chen TF
author_facet	Yang F Fang XY Jiang WT Chen TF
author_sort	Yang F
title	Bioresponsive cancer-targeted polysaccharide nanosystem to inhibit angiogenesis
title_short	Bioresponsive cancer-targeted polysaccharide nanosystem to inhibit angiogenesis
title_full	Bioresponsive cancer-targeted polysaccharide nanosystem to inhibit angiogenesis
title_fullStr	Bioresponsive cancer-targeted polysaccharide nanosystem to inhibit angiogenesis
title_full_unstemmed	Bioresponsive cancer-targeted polysaccharide nanosystem to inhibit angiogenesis
title_sort	bioresponsive cancer-targeted polysaccharide nanosystem to inhibit angiogenesis
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/3222de9c550845e589b30c0cd48c76b8
work_keys_str_mv	AT yangf bioresponsivecancertargetedpolysaccharidenanosystemtoinhibitangiogenesis AT fangxy bioresponsivecancertargetedpolysaccharidenanosystemtoinhibitangiogenesis AT jiangwt bioresponsivecancertargetedpolysaccharidenanosystemtoinhibitangiogenesis AT chentf bioresponsivecancertargetedpolysaccharidenanosystemtoinhibitangiogenesis
_version_	1718403307807965184

Bioresponsive cancer-targeted polysaccharide nanosystem to inhibit angiogenesis

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