The role of gene to gene interaction in the breast’s genomic signature of pregnancy

Abstract Full-term pregnancy at an early age confers long-term protection against breast cancer. Published data shows a specific transcriptomic profile controlling chromatin remodeling that could play a relevant role in the pregnancy-induced protection. This process of chromatin remodeling, induced...

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Autores principales:	Pedro J. Gutiérrez-Díez, Javier Gomez-Pilar, Roberto Hornero, Julia Martínez-Rodríguez, Miguel A. López-Marcos, Jose Russo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3223eae22a364b4e9b9edc0f546f2339
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spelling	oai:doaj.org-article:3223eae22a364b4e9b9edc0f546f23392021-12-02T13:23:49ZThe role of gene to gene interaction in the breast’s genomic signature of pregnancy10.1038/s41598-021-81704-82045-2322https://doaj.org/article/3223eae22a364b4e9b9edc0f546f23392021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-81704-8https://doaj.org/toc/2045-2322Abstract Full-term pregnancy at an early age confers long-term protection against breast cancer. Published data shows a specific transcriptomic profile controlling chromatin remodeling that could play a relevant role in the pregnancy-induced protection. This process of chromatin remodeling, induced by the breast differentiation caused by the first full-term pregnancy, has mainly been measured by the expression level of genes individually considered. However, genes equally expressed during the process of chromatin remodeling may behave differently in their interaction with other genes. These changes at the gene cluster level could constitute an additional dimension of chromatin remodeling and therefore of the pregnancy-induced protection. In this research, we apply Information and Graph Theories, Differential Co-expression Network Analysis, and Multiple Regression Analysis, specially designed to examine structural and informational aspects of data sets, to analyze this question. Our findings demonstrate that, independently of the changes in the gene expression at the individual level, there are significant changes in gene–gene interactions and gene cluster behaviors. These changes indicate that the parous breast, through the process of early full-term pregnancy, generates more modules in the networks, with higher density, and a genomic structure performing additional and more complex functions than those found in the nulliparous breast.Pedro J. Gutiérrez-DíezJavier Gomez-PilarRoberto HorneroJulia Martínez-RodríguezMiguel A. López-MarcosJose RussoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Pedro J. Gutiérrez-Díez Javier Gomez-Pilar Roberto Hornero Julia Martínez-Rodríguez Miguel A. López-Marcos Jose Russo The role of gene to gene interaction in the breast’s genomic signature of pregnancy
description	Abstract Full-term pregnancy at an early age confers long-term protection against breast cancer. Published data shows a specific transcriptomic profile controlling chromatin remodeling that could play a relevant role in the pregnancy-induced protection. This process of chromatin remodeling, induced by the breast differentiation caused by the first full-term pregnancy, has mainly been measured by the expression level of genes individually considered. However, genes equally expressed during the process of chromatin remodeling may behave differently in their interaction with other genes. These changes at the gene cluster level could constitute an additional dimension of chromatin remodeling and therefore of the pregnancy-induced protection. In this research, we apply Information and Graph Theories, Differential Co-expression Network Analysis, and Multiple Regression Analysis, specially designed to examine structural and informational aspects of data sets, to analyze this question. Our findings demonstrate that, independently of the changes in the gene expression at the individual level, there are significant changes in gene–gene interactions and gene cluster behaviors. These changes indicate that the parous breast, through the process of early full-term pregnancy, generates more modules in the networks, with higher density, and a genomic structure performing additional and more complex functions than those found in the nulliparous breast.
format	article
author	Pedro J. Gutiérrez-Díez Javier Gomez-Pilar Roberto Hornero Julia Martínez-Rodríguez Miguel A. López-Marcos Jose Russo
author_facet	Pedro J. Gutiérrez-Díez Javier Gomez-Pilar Roberto Hornero Julia Martínez-Rodríguez Miguel A. López-Marcos Jose Russo
author_sort	Pedro J. Gutiérrez-Díez
title	The role of gene to gene interaction in the breast’s genomic signature of pregnancy
title_short	The role of gene to gene interaction in the breast’s genomic signature of pregnancy
title_full	The role of gene to gene interaction in the breast’s genomic signature of pregnancy
title_fullStr	The role of gene to gene interaction in the breast’s genomic signature of pregnancy
title_full_unstemmed	The role of gene to gene interaction in the breast’s genomic signature of pregnancy
title_sort	role of gene to gene interaction in the breast’s genomic signature of pregnancy
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/3223eae22a364b4e9b9edc0f546f2339
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The role of gene to gene interaction in the breast’s genomic signature of pregnancy

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