TGF-β Signaling and Resistance to Cancer Therapy
The transforming growth factor β (TGF-β) pathway, which is well studied for its ability to inhibit cell proliferation in early stages of tumorigenesis while promoting epithelial-mesenchymal transition and invasion in advanced cancer, is considered to act as a double-edged sword in cancer. Multiple i...
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Frontiers Media S.A.
2021
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oai:doaj.org-article:32246b949cc74d93a2c11dfb1e2ea4b92021-12-01T17:01:14ZTGF-β Signaling and Resistance to Cancer Therapy2296-634X10.3389/fcell.2021.786728https://doaj.org/article/32246b949cc74d93a2c11dfb1e2ea4b92021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcell.2021.786728/fullhttps://doaj.org/toc/2296-634XThe transforming growth factor β (TGF-β) pathway, which is well studied for its ability to inhibit cell proliferation in early stages of tumorigenesis while promoting epithelial-mesenchymal transition and invasion in advanced cancer, is considered to act as a double-edged sword in cancer. Multiple inhibitors have been developed to target TGF-β signaling, but results from clinical trials were inconsistent, suggesting that the functions of TGF-β in human cancers are not yet fully explored. Multiple drug resistance is a major challenge in cancer therapy; emerging evidence indicates that TGF-β signaling may be a key factor in cancer resistance to chemotherapy, targeted therapy and immunotherapy. Finally, combining anti-TGF-β therapy with other cancer therapy is an attractive venue to be explored for the treatment of therapy-resistant cancer.Maoduo ZhangMaoduo ZhangMaoduo ZhangYing Yi ZhangYongze ChenJia WangJia WangJia WangQiang WangQiang WangQiang WangHezhe LuHezhe LuHezhe LuFrontiers Media S.A.articleTGF-β pathwayTGF-βchemotherapy resistancetargeted therapy resistanceimmunotherapy resistanceBiology (General)QH301-705.5ENFrontiers in Cell and Developmental Biology, Vol 9 (2021) |
| institution |
DOAJ |
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DOAJ |
| language |
EN |
| topic |
TGF-β pathway TGF-β chemotherapy resistance targeted therapy resistance immunotherapy resistance Biology (General) QH301-705.5 |
| spellingShingle |
TGF-β pathway TGF-β chemotherapy resistance targeted therapy resistance immunotherapy resistance Biology (General) QH301-705.5 Maoduo Zhang Maoduo Zhang Maoduo Zhang Ying Yi Zhang Yongze Chen Jia Wang Jia Wang Jia Wang Qiang Wang Qiang Wang Qiang Wang Hezhe Lu Hezhe Lu Hezhe Lu TGF-β Signaling and Resistance to Cancer Therapy |
| description |
The transforming growth factor β (TGF-β) pathway, which is well studied for its ability to inhibit cell proliferation in early stages of tumorigenesis while promoting epithelial-mesenchymal transition and invasion in advanced cancer, is considered to act as a double-edged sword in cancer. Multiple inhibitors have been developed to target TGF-β signaling, but results from clinical trials were inconsistent, suggesting that the functions of TGF-β in human cancers are not yet fully explored. Multiple drug resistance is a major challenge in cancer therapy; emerging evidence indicates that TGF-β signaling may be a key factor in cancer resistance to chemotherapy, targeted therapy and immunotherapy. Finally, combining anti-TGF-β therapy with other cancer therapy is an attractive venue to be explored for the treatment of therapy-resistant cancer. |
| format |
article |
| author |
Maoduo Zhang Maoduo Zhang Maoduo Zhang Ying Yi Zhang Yongze Chen Jia Wang Jia Wang Jia Wang Qiang Wang Qiang Wang Qiang Wang Hezhe Lu Hezhe Lu Hezhe Lu |
| author_facet |
Maoduo Zhang Maoduo Zhang Maoduo Zhang Ying Yi Zhang Yongze Chen Jia Wang Jia Wang Jia Wang Qiang Wang Qiang Wang Qiang Wang Hezhe Lu Hezhe Lu Hezhe Lu |
| author_sort |
Maoduo Zhang |
| title |
TGF-β Signaling and Resistance to Cancer Therapy |
| title_short |
TGF-β Signaling and Resistance to Cancer Therapy |
| title_full |
TGF-β Signaling and Resistance to Cancer Therapy |
| title_fullStr |
TGF-β Signaling and Resistance to Cancer Therapy |
| title_full_unstemmed |
TGF-β Signaling and Resistance to Cancer Therapy |
| title_sort |
tgf-β signaling and resistance to cancer therapy |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/32246b949cc74d93a2c11dfb1e2ea4b9 |
| work_keys_str_mv |
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