c-Myc inactivation of p53 through the pan-cancer lncRNA MILIP drives cancer pathogenesis

c-Myc and p53 operate in a negative feedback manner to maintain cellular homeostasis. Here, the authors report a long noncoding RNA, MILIP as a downstream target of c-Myc and that MILIP represses p53 to support tumorigenicity.

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Autores principales:	Yu Chen Feng, Xiao Ying Liu, Liu Teng, Qiang Ji, Yongyan Wu, Jin Ming Li, Wei Gao, Yuan Yuan Zhang, Ting La, Hessam Tabatabaee, Xu Guang Yan, M. Fairuz B. Jamaluddin, Didi Zhang, Su Tang Guo, Rodney J. Scott, Tao Liu, Rick F. Thorne, Xu Dong Zhang, Lei Jin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3225348bd84d4f1584b3eda3c5bdafbd
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:3225348bd84d4f1584b3eda3c5bdafbd2021-12-02T18:09:04Zc-Myc inactivation of p53 through the pan-cancer lncRNA MILIP drives cancer pathogenesis10.1038/s41467-020-18735-82041-1723https://doaj.org/article/3225348bd84d4f1584b3eda3c5bdafbd2020-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18735-8https://doaj.org/toc/2041-1723c-Myc and p53 operate in a negative feedback manner to maintain cellular homeostasis. Here, the authors report a long noncoding RNA, MILIP as a downstream target of c-Myc and that MILIP represses p53 to support tumorigenicity.Yu Chen FengXiao Ying LiuLiu TengQiang JiYongyan WuJin Ming LiWei GaoYuan Yuan ZhangTing LaHessam TabatabaeeXu Guang YanM. Fairuz B. JamaluddinDidi ZhangSu Tang GuoRodney J. ScottTao LiuRick F. ThorneXu Dong ZhangLei JinNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yu Chen Feng Xiao Ying Liu Liu Teng Qiang Ji Yongyan Wu Jin Ming Li Wei Gao Yuan Yuan Zhang Ting La Hessam Tabatabaee Xu Guang Yan M. Fairuz B. Jamaluddin Didi Zhang Su Tang Guo Rodney J. Scott Tao Liu Rick F. Thorne Xu Dong Zhang Lei Jin c-Myc inactivation of p53 through the pan-cancer lncRNA MILIP drives cancer pathogenesis
description	c-Myc and p53 operate in a negative feedback manner to maintain cellular homeostasis. Here, the authors report a long noncoding RNA, MILIP as a downstream target of c-Myc and that MILIP represses p53 to support tumorigenicity.
format	article
author	Yu Chen Feng Xiao Ying Liu Liu Teng Qiang Ji Yongyan Wu Jin Ming Li Wei Gao Yuan Yuan Zhang Ting La Hessam Tabatabaee Xu Guang Yan M. Fairuz B. Jamaluddin Didi Zhang Su Tang Guo Rodney J. Scott Tao Liu Rick F. Thorne Xu Dong Zhang Lei Jin
author_facet	Yu Chen Feng Xiao Ying Liu Liu Teng Qiang Ji Yongyan Wu Jin Ming Li Wei Gao Yuan Yuan Zhang Ting La Hessam Tabatabaee Xu Guang Yan M. Fairuz B. Jamaluddin Didi Zhang Su Tang Guo Rodney J. Scott Tao Liu Rick F. Thorne Xu Dong Zhang Lei Jin
author_sort	Yu Chen Feng
title	c-Myc inactivation of p53 through the pan-cancer lncRNA MILIP drives cancer pathogenesis
title_short	c-Myc inactivation of p53 through the pan-cancer lncRNA MILIP drives cancer pathogenesis
title_full	c-Myc inactivation of p53 through the pan-cancer lncRNA MILIP drives cancer pathogenesis
title_fullStr	c-Myc inactivation of p53 through the pan-cancer lncRNA MILIP drives cancer pathogenesis
title_full_unstemmed	c-Myc inactivation of p53 through the pan-cancer lncRNA MILIP drives cancer pathogenesis
title_sort	c-myc inactivation of p53 through the pan-cancer lncrna milip drives cancer pathogenesis
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/3225348bd84d4f1584b3eda3c5bdafbd
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c-Myc inactivation of p53 through the pan-cancer lncRNA MILIP drives cancer pathogenesis

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