Role of TGF-β1 Codon 10 Polymorphism in Chronic Hepatitis C Patients

BACKGROUND AND OBJECTIVE: Transforming growth factor beta (TGF-β) has an inhibitory role in homeostasis of T-cell response and regulatory T cells and regulation of immune response against viral infections. Codon 10 of protein is located in the signal peptide and involved in secretion of cytokine. Th...

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Autores principales:	P Azimzadeh, SR Mohebbi, S Romani, SH Kazemian, H irtalebi, M Vahedi, F Derakhshan, MR Zali
Formato:	article
Lenguaje:	EN FA
Publicado:	Babol University of Medical Sciences 2011
Materias:	hepatitis c cytokine polymorphism Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/32256d559cf74492a712da8f428b086a
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spelling	oai:doaj.org-article:32256d559cf74492a712da8f428b086a2021-11-10T08:56:42ZRole of TGF-β1 Codon 10 Polymorphism in Chronic Hepatitis C Patients1561-41072251-7170https://doaj.org/article/32256d559cf74492a712da8f428b086a2011-07-01T00:00:00Zhttp://jbums.org/article-1-3839-en.htmlhttps://doaj.org/toc/1561-4107https://doaj.org/toc/2251-7170BACKGROUND AND OBJECTIVE: Transforming growth factor beta (TGF-β) has an inhibitory role in homeostasis of T-cell response and regulatory T cells and regulation of immune response against viral infections. Codon 10 of protein is located in the signal peptide and involved in secretion of cytokine. The aim of this study was to investigate the association of leu-pro polymorphism of codon 10 and hepatitis C susceptibility in patients.METHODS: This case-control study was performed on 112 chronic hepatitis C patients and 122 healthy control subjects. TGF-β1 gene was amplified with PCR method and genotypes were determined using Restriction Fragment Length Polymorphism (RFLP) with MspA1I restriction enzyme.FINDINGS: The frequency of CT genotype in both groups was higher than CC and TT. Genotyping results for CC, CT and TT states in patients was 50%, 19.6% and 30.4% and in healthy controls was 59%, 13.9% and 27.1% respectively. We found no significant difference between patients and healthy controls according to codon 10 polymorphism. CONCLUSION: According to the results of this study, no relationship was found between this protein’s genetic variations and chronic hepatitis C infection susceptibility.P AzimzadehSR MohebbiS RomaniSH KazemianH irtalebiM VahediF DerakhshanMR ZaliBabol University of Medical Sciencesarticlehepatitis ccytokinepolymorphismMedicineRMedicine (General)R5-920ENFAMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 13, Iss 4, Pp 26-33 (2011)
institution	DOAJ
collection	DOAJ
language	EN FA
topic	hepatitis c cytokine polymorphism Medicine R Medicine (General) R5-920
spellingShingle	hepatitis c cytokine polymorphism Medicine R Medicine (General) R5-920 P Azimzadeh SR Mohebbi S Romani SH Kazemian H irtalebi M Vahedi F Derakhshan MR Zali Role of TGF-β1 Codon 10 Polymorphism in Chronic Hepatitis C Patients
description	BACKGROUND AND OBJECTIVE: Transforming growth factor beta (TGF-β) has an inhibitory role in homeostasis of T-cell response and regulatory T cells and regulation of immune response against viral infections. Codon 10 of protein is located in the signal peptide and involved in secretion of cytokine. The aim of this study was to investigate the association of leu-pro polymorphism of codon 10 and hepatitis C susceptibility in patients.METHODS: This case-control study was performed on 112 chronic hepatitis C patients and 122 healthy control subjects. TGF-β1 gene was amplified with PCR method and genotypes were determined using Restriction Fragment Length Polymorphism (RFLP) with MspA1I restriction enzyme.FINDINGS: The frequency of CT genotype in both groups was higher than CC and TT. Genotyping results for CC, CT and TT states in patients was 50%, 19.6% and 30.4% and in healthy controls was 59%, 13.9% and 27.1% respectively. We found no significant difference between patients and healthy controls according to codon 10 polymorphism. CONCLUSION: According to the results of this study, no relationship was found between this protein’s genetic variations and chronic hepatitis C infection susceptibility.
format	article
author	P Azimzadeh SR Mohebbi S Romani SH Kazemian H irtalebi M Vahedi F Derakhshan MR Zali
author_facet	P Azimzadeh SR Mohebbi S Romani SH Kazemian H irtalebi M Vahedi F Derakhshan MR Zali
author_sort	P Azimzadeh
title	Role of TGF-β1 Codon 10 Polymorphism in Chronic Hepatitis C Patients
title_short	Role of TGF-β1 Codon 10 Polymorphism in Chronic Hepatitis C Patients
title_full	Role of TGF-β1 Codon 10 Polymorphism in Chronic Hepatitis C Patients
title_fullStr	Role of TGF-β1 Codon 10 Polymorphism in Chronic Hepatitis C Patients
title_full_unstemmed	Role of TGF-β1 Codon 10 Polymorphism in Chronic Hepatitis C Patients
title_sort	role of tgf-β1 codon 10 polymorphism in chronic hepatitis c patients
publisher	Babol University of Medical Sciences
publishDate	2011
url	https://doaj.org/article/32256d559cf74492a712da8f428b086a
work_keys_str_mv	AT pazimzadeh roleoftgfb1codon10polymorphisminchronichepatitiscpatients AT srmohebbi roleoftgfb1codon10polymorphisminchronichepatitiscpatients AT sromani roleoftgfb1codon10polymorphisminchronichepatitiscpatients AT shkazemian roleoftgfb1codon10polymorphisminchronichepatitiscpatients AT hirtalebi roleoftgfb1codon10polymorphisminchronichepatitiscpatients AT mvahedi roleoftgfb1codon10polymorphisminchronichepatitiscpatients AT fderakhshan roleoftgfb1codon10polymorphisminchronichepatitiscpatients AT mrzali roleoftgfb1codon10polymorphisminchronichepatitiscpatients
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Role of TGF-β1 Codon 10 Polymorphism in Chronic Hepatitis C Patients

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