Brain-to-cervical lymph node signaling after stroke

Brain damage induces systemic inflammation, but insights and implication of this induction is still unclear. Here the authors show, using rat and mouse focal cerebral ischemia models, that the damaged brain signals via the VEGF-C/VEFGR3 axis to activate inflammatory responses in the draining cervica...

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Autores principales:	Elga Esposito, Bum Ju Ahn, Jingfei Shi, Yoshihiko Nakamura, Ji Hyun Park, Emiri T. Mandeville, Zhanyang Yu, Su Jing Chan, Rakhi Desai, Ayumi Hayakawa, Xunming Ji, Eng H. Lo, Kazuhide Hayakawa
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3229fe5e6272458e8c1e4a8c709dd2ba
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spelling	oai:doaj.org-article:3229fe5e6272458e8c1e4a8c709dd2ba2021-12-02T17:32:40ZBrain-to-cervical lymph node signaling after stroke10.1038/s41467-019-13324-w2041-1723https://doaj.org/article/3229fe5e6272458e8c1e4a8c709dd2ba2019-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13324-whttps://doaj.org/toc/2041-1723Brain damage induces systemic inflammation, but insights and implication of this induction is still unclear. Here the authors show, using rat and mouse focal cerebral ischemia models, that the damaged brain signals via the VEGF-C/VEFGR3 axis to activate inflammatory responses in the draining cervical lymph nodes to induce systemic inflammation.Elga EspositoBum Ju AhnJingfei ShiYoshihiko NakamuraJi Hyun ParkEmiri T. MandevilleZhanyang YuSu Jing ChanRakhi DesaiAyumi HayakawaXunming JiEng H. LoKazuhide HayakawaNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Elga Esposito Bum Ju Ahn Jingfei Shi Yoshihiko Nakamura Ji Hyun Park Emiri T. Mandeville Zhanyang Yu Su Jing Chan Rakhi Desai Ayumi Hayakawa Xunming Ji Eng H. Lo Kazuhide Hayakawa Brain-to-cervical lymph node signaling after stroke
description	Brain damage induces systemic inflammation, but insights and implication of this induction is still unclear. Here the authors show, using rat and mouse focal cerebral ischemia models, that the damaged brain signals via the VEGF-C/VEFGR3 axis to activate inflammatory responses in the draining cervical lymph nodes to induce systemic inflammation.
format	article
author	Elga Esposito Bum Ju Ahn Jingfei Shi Yoshihiko Nakamura Ji Hyun Park Emiri T. Mandeville Zhanyang Yu Su Jing Chan Rakhi Desai Ayumi Hayakawa Xunming Ji Eng H. Lo Kazuhide Hayakawa
author_facet	Elga Esposito Bum Ju Ahn Jingfei Shi Yoshihiko Nakamura Ji Hyun Park Emiri T. Mandeville Zhanyang Yu Su Jing Chan Rakhi Desai Ayumi Hayakawa Xunming Ji Eng H. Lo Kazuhide Hayakawa
author_sort	Elga Esposito
title	Brain-to-cervical lymph node signaling after stroke
title_short	Brain-to-cervical lymph node signaling after stroke
title_full	Brain-to-cervical lymph node signaling after stroke
title_fullStr	Brain-to-cervical lymph node signaling after stroke
title_full_unstemmed	Brain-to-cervical lymph node signaling after stroke
title_sort	brain-to-cervical lymph node signaling after stroke
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/3229fe5e6272458e8c1e4a8c709dd2ba
work_keys_str_mv	AT elgaesposito braintocervicallymphnodesignalingafterstroke AT bumjuahn braintocervicallymphnodesignalingafterstroke AT jingfeishi braintocervicallymphnodesignalingafterstroke AT yoshihikonakamura braintocervicallymphnodesignalingafterstroke AT jihyunpark braintocervicallymphnodesignalingafterstroke AT emiritmandeville braintocervicallymphnodesignalingafterstroke AT zhanyangyu braintocervicallymphnodesignalingafterstroke AT sujingchan braintocervicallymphnodesignalingafterstroke AT rakhidesai braintocervicallymphnodesignalingafterstroke AT ayumihayakawa braintocervicallymphnodesignalingafterstroke AT xunmingji braintocervicallymphnodesignalingafterstroke AT enghlo braintocervicallymphnodesignalingafterstroke AT kazuhidehayakawa braintocervicallymphnodesignalingafterstroke
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Brain-to-cervical lymph node signaling after stroke

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