Role and Function of T Cell-Derived Exosomes and Their Therapeutic Value

Exosomes are membrane-bound extracellular vesicles that are produced in the endosomal compartment of most eukaryotic cells. Containing proteins, RNA, and DNA, exosomes mediate intercellular communication between different cell types by transferring their contents and thus are involved in numerous ph...

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Autores principales:	Yuanyuan Shao, Xiaofeng Pan, Rong Fu
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi Limited 2021
Materias:	Pathology RB1-214
Acceso en línea:	https://doaj.org/article/322b99029e23490291ae53b1d978e913
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spelling	oai:doaj.org-article:322b99029e23490291ae53b1d978e9132021-11-22T01:10:54ZRole and Function of T Cell-Derived Exosomes and Their Therapeutic Value1466-186110.1155/2021/8481013https://doaj.org/article/322b99029e23490291ae53b1d978e9132021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/8481013https://doaj.org/toc/1466-1861Exosomes are membrane-bound extracellular vesicles that are produced in the endosomal compartment of most eukaryotic cells. Containing proteins, RNA, and DNA, exosomes mediate intercellular communication between different cell types by transferring their contents and thus are involved in numerous physiological and pathological processes. T cells are an indispensable part of adaptive immunity, and the functions of T cell-derived exosomes have been widely studied. In the more than three decades since the discovery of exosomes, several studies have revealed that T cell-derived exosomes play a novel role in cell-to-cell signaling, especially in inflammatory responses, autoimmunity, and infectious diseases. In this review, we will summarize the function of T cell-derived exosomes and their therapeutic potential.Yuanyuan ShaoXiaofeng PanRong FuHindawi LimitedarticlePathologyRB1-214ENMediators of Inflammation, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Pathology RB1-214
spellingShingle	Pathology RB1-214 Yuanyuan Shao Xiaofeng Pan Rong Fu Role and Function of T Cell-Derived Exosomes and Their Therapeutic Value
description	Exosomes are membrane-bound extracellular vesicles that are produced in the endosomal compartment of most eukaryotic cells. Containing proteins, RNA, and DNA, exosomes mediate intercellular communication between different cell types by transferring their contents and thus are involved in numerous physiological and pathological processes. T cells are an indispensable part of adaptive immunity, and the functions of T cell-derived exosomes have been widely studied. In the more than three decades since the discovery of exosomes, several studies have revealed that T cell-derived exosomes play a novel role in cell-to-cell signaling, especially in inflammatory responses, autoimmunity, and infectious diseases. In this review, we will summarize the function of T cell-derived exosomes and their therapeutic potential.
format	article
author	Yuanyuan Shao Xiaofeng Pan Rong Fu
author_facet	Yuanyuan Shao Xiaofeng Pan Rong Fu
author_sort	Yuanyuan Shao
title	Role and Function of T Cell-Derived Exosomes and Their Therapeutic Value
title_short	Role and Function of T Cell-Derived Exosomes and Their Therapeutic Value
title_full	Role and Function of T Cell-Derived Exosomes and Their Therapeutic Value
title_fullStr	Role and Function of T Cell-Derived Exosomes and Their Therapeutic Value
title_full_unstemmed	Role and Function of T Cell-Derived Exosomes and Their Therapeutic Value
title_sort	role and function of t cell-derived exosomes and their therapeutic value
publisher	Hindawi Limited
publishDate	2021
url	https://doaj.org/article/322b99029e23490291ae53b1d978e913
work_keys_str_mv	AT yuanyuanshao roleandfunctionoftcellderivedexosomesandtheirtherapeuticvalue AT xiaofengpan roleandfunctionoftcellderivedexosomesandtheirtherapeuticvalue AT rongfu roleandfunctionoftcellderivedexosomesandtheirtherapeuticvalue
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Role and Function of T Cell-Derived Exosomes and Their Therapeutic Value

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