The Effect of Gandar usa Leaf Extract (Justicia gendar ussa Bur m F.) Administration on Estradiol Hor mone Level and the Amount of Antral Administration on Estradiol Hor mone Level and the Amount of Antral Ovarium Follicle on Female Mice
Background: Physiologically, woman experiencing aging characterized by menopause. Gandar usa leaf contains isof lavon, a phytoesterogen expected to be used as esterogen replacement therapy. Objective: the aim of this research is to investigate the administrative ef fect of gandar usa leaf extract o...
Guardado en:
| Autores principales: | , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Universitas Sultan Agung Semarang
2018
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/322eb9227b8749f4b9f2cb7181395218 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:322eb9227b8749f4b9f2cb7181395218 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:322eb9227b8749f4b9f2cb71813952182021-11-25T13:16:08ZThe Effect of Gandar usa Leaf Extract (Justicia gendar ussa Bur m F.) Administration on Estradiol Hor mone Level and the Amount of Antral Administration on Estradiol Hor mone Level and the Amount of Antral Ovarium Follicle on Female Mice2085-15452339-093X10.30659/sainsmed.v9i2.2099https://doaj.org/article/322eb9227b8749f4b9f2cb71813952182018-12-01T00:00:00Zhttp://jurnal.unissula.ac.id/index.php/sainsmedika/article/view/2099https://doaj.org/toc/2085-1545https://doaj.org/toc/2339-093XBackground: Physiologically, woman experiencing aging characterized by menopause. Gandar usa leaf contains isof lavon, a phytoesterogen expected to be used as esterogen replacement therapy. Objective: the aim of this research is to investigate the administrative ef fect of gandar usa leaf extract on the increase of estradiol hor mone level and the number of antral ovarium follicle of female mice. Methods: This is experimental study with posttest only control group research design. Samples are 24 balb-c female mice, aged 16-17 months, weighed 19-35 grams, divided into 4 groups. Control group (Ctrl-G) were given 0.48 ml aquadest; group JB10-G, JB20-G, and JB30-G, each were given gandar usa leaf extract with concentration 10%, 20%, dan 30% in volume 0.48 ml orally twice a day. Af ter treatment, dissection were conducted to make ovarium histology preparation with Hematoxylin Ehrlich-Eosin staining, obser vation were conducted using microscope. Results: Post hoc analysis indicated that the estradiol level and the number of antral ovarium follicle on administration of gandar usa leaf extract with concentration 10%, 20%, dan 30% are signif icantly higher, p < 0.05. The increase of estradiol level with extract concentration of 10% are signif icantly negatively cor related with the number of antral ovarium follicles p<0.05. negatively cor related with the number of antral ovarium follicles p<0.05. Conclusion: The administration of gandar usa leaf extract increase the estradiol hor mone level and the number of antral ovarium follicle in female mice.Ni'mah Hidayatul LailiTaufiqurrachman NasihunTitiek SumarawatiUniversitas Sultan Agung SemarangarticleMedicine (General)R5-920ENSains Medika, Vol 9, Iss 2, Pp 56-61 (2018) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Medicine (General) R5-920 |
| spellingShingle |
Medicine (General) R5-920 Ni'mah Hidayatul Laili Taufiqurrachman Nasihun Titiek Sumarawati The Effect of Gandar usa Leaf Extract (Justicia gendar ussa Bur m F.) Administration on Estradiol Hor mone Level and the Amount of Antral Administration on Estradiol Hor mone Level and the Amount of Antral Ovarium Follicle on Female Mice |
| description |
Background: Physiologically, woman experiencing aging characterized by menopause. Gandar usa leaf contains isof lavon, a phytoesterogen expected to be used as esterogen replacement therapy.
Objective: the aim of this research is to investigate the administrative ef fect of gandar usa leaf extract on the increase of estradiol hor mone level and the number of antral ovarium follicle of female mice.
Methods: This is experimental study with posttest only control group research design. Samples are 24 balb-c female mice, aged 16-17 months, weighed 19-35 grams, divided into 4 groups. Control group (Ctrl-G) were given 0.48 ml aquadest; group JB10-G, JB20-G, and JB30-G, each were given gandar usa leaf extract with concentration 10%, 20%, dan 30% in volume 0.48 ml orally twice a day. Af ter treatment, dissection were conducted to make ovarium histology preparation with Hematoxylin Ehrlich-Eosin staining, obser vation were conducted using microscope.
Results: Post hoc analysis indicated that the estradiol level and the number of antral ovarium follicle on administration of gandar usa leaf extract with concentration 10%, 20%, dan 30% are signif icantly higher, p < 0.05. The increase of estradiol level with extract concentration of 10% are signif icantly negatively cor related with the number of antral ovarium follicles p<0.05. negatively cor related with the number of antral ovarium follicles p<0.05.
Conclusion: The administration of gandar usa leaf extract increase the estradiol hor mone level and the number of antral ovarium follicle in female mice. |
| format |
article |
| author |
Ni'mah Hidayatul Laili Taufiqurrachman Nasihun Titiek Sumarawati |
| author_facet |
Ni'mah Hidayatul Laili Taufiqurrachman Nasihun Titiek Sumarawati |
| author_sort |
Ni'mah Hidayatul Laili |
| title |
The Effect of Gandar usa Leaf Extract (Justicia gendar ussa Bur m F.) Administration on Estradiol Hor mone Level and the Amount of Antral Administration on Estradiol Hor mone Level and the Amount of Antral Ovarium Follicle on Female Mice |
| title_short |
The Effect of Gandar usa Leaf Extract (Justicia gendar ussa Bur m F.) Administration on Estradiol Hor mone Level and the Amount of Antral Administration on Estradiol Hor mone Level and the Amount of Antral Ovarium Follicle on Female Mice |
| title_full |
The Effect of Gandar usa Leaf Extract (Justicia gendar ussa Bur m F.) Administration on Estradiol Hor mone Level and the Amount of Antral Administration on Estradiol Hor mone Level and the Amount of Antral Ovarium Follicle on Female Mice |
| title_fullStr |
The Effect of Gandar usa Leaf Extract (Justicia gendar ussa Bur m F.) Administration on Estradiol Hor mone Level and the Amount of Antral Administration on Estradiol Hor mone Level and the Amount of Antral Ovarium Follicle on Female Mice |
| title_full_unstemmed |
The Effect of Gandar usa Leaf Extract (Justicia gendar ussa Bur m F.) Administration on Estradiol Hor mone Level and the Amount of Antral Administration on Estradiol Hor mone Level and the Amount of Antral Ovarium Follicle on Female Mice |
| title_sort |
effect of gandar usa leaf extract (justicia gendar ussa bur m f.) administration on estradiol hor mone level and the amount of antral administration on estradiol hor mone level and the amount of antral ovarium follicle on female mice |
| publisher |
Universitas Sultan Agung Semarang |
| publishDate |
2018 |
| url |
https://doaj.org/article/322eb9227b8749f4b9f2cb7181395218 |
| work_keys_str_mv |
AT nimahhidayatullaili theeffectofgandarusaleafextractjusticiagendarussaburmfadministrationonestradiolhormonelevelandtheamountofantraladministrationonestradiolhormonelevelandtheamountofantralovariumfollicleonfemalemice AT taufiqurrachmannasihun theeffectofgandarusaleafextractjusticiagendarussaburmfadministrationonestradiolhormonelevelandtheamountofantraladministrationonestradiolhormonelevelandtheamountofantralovariumfollicleonfemalemice AT titieksumarawati theeffectofgandarusaleafextractjusticiagendarussaburmfadministrationonestradiolhormonelevelandtheamountofantraladministrationonestradiolhormonelevelandtheamountofantralovariumfollicleonfemalemice AT nimahhidayatullaili effectofgandarusaleafextractjusticiagendarussaburmfadministrationonestradiolhormonelevelandtheamountofantraladministrationonestradiolhormonelevelandtheamountofantralovariumfollicleonfemalemice AT taufiqurrachmannasihun effectofgandarusaleafextractjusticiagendarussaburmfadministrationonestradiolhormonelevelandtheamountofantraladministrationonestradiolhormonelevelandtheamountofantralovariumfollicleonfemalemice AT titieksumarawati effectofgandarusaleafextractjusticiagendarussaburmfadministrationonestradiolhormonelevelandtheamountofantraladministrationonestradiolhormonelevelandtheamountofantralovariumfollicleonfemalemice |
| _version_ |
1718413489134895104 |