Predictors of slow clinical response and extended treatment in patients with extra-pulmonary tuberculosis in Pakistan, A hospital-based prospective study.

The optimal duration of treatment in different forms of extrapulmonary tuberculosis (EPTB) is not clearly defined. This study aimed to identify predictors of slow clinical response and extended anti-TB treatment in EPTB patients. Socio-demographic, clinical, and microbiological characteristics of EP...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Atiqa Ambreen, Sabira Tahseen, Ahmad Wali, Muhammad Jamil, Syed Zeeshan Haider Naqvi, Nauman Safdar, Tehmina Mustafa
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/32365d60f6f8404e9cbc29cdee830332
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:32365d60f6f8404e9cbc29cdee830332
record_format	dspace
spelling	oai:doaj.org-article:32365d60f6f8404e9cbc29cdee8303322021-12-02T20:13:13ZPredictors of slow clinical response and extended treatment in patients with extra-pulmonary tuberculosis in Pakistan, A hospital-based prospective study.1932-620310.1371/journal.pone.0259801https://doaj.org/article/32365d60f6f8404e9cbc29cdee8303322021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0259801https://doaj.org/toc/1932-6203The optimal duration of treatment in different forms of extrapulmonary tuberculosis (EPTB) is not clearly defined. This study aimed to identify predictors of slow clinical response and extended anti-TB treatment in EPTB patients. Socio-demographic, clinical, and microbiological characteristics of EPTB patients registered for anti-TB treatment at a tertiary care hospital, were analysed for identification of predictors of extended treatment. A total of 251 patients (137 lymphadenitis, and 114 pleuritis) were included in the analysis. Treatment was extended to more than 6 months in 58/251 (23%) patients. In the multivariate regression analysis, culture-positive EPTB (p = 0.007) [OR (95% CI) = 3.81 (1.43, 10.11)], history of diabetes (p = 0.014) [OR (95% CI) = 25.18 (1.94, 325.83)], smokeless tobacco use (p = 0.002) [OR (95% CI) = 17.69 (2.80, 111.72)], and slow regression of local signs and symptoms after 2 months of treatment (p < 0.001) [OR (95% CI) = 17.09 [(5.79, 50.39)] were seen to be significantly associated with treatment extension. Identification of predictors of extended treatment can help clinical decisions regarding optimal duration of treatment. Further studies are needed to identify subgroups of EPTB patients who can benefit from a shorter or longer treatment regimen.Atiqa AmbreenSabira TahseenAhmad WaliMuhammad JamilSyed Zeeshan Haider NaqviNauman SafdarTehmina MustafaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 11, p e0259801 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Atiqa Ambreen Sabira Tahseen Ahmad Wali Muhammad Jamil Syed Zeeshan Haider Naqvi Nauman Safdar Tehmina Mustafa Predictors of slow clinical response and extended treatment in patients with extra-pulmonary tuberculosis in Pakistan, A hospital-based prospective study.
description	The optimal duration of treatment in different forms of extrapulmonary tuberculosis (EPTB) is not clearly defined. This study aimed to identify predictors of slow clinical response and extended anti-TB treatment in EPTB patients. Socio-demographic, clinical, and microbiological characteristics of EPTB patients registered for anti-TB treatment at a tertiary care hospital, were analysed for identification of predictors of extended treatment. A total of 251 patients (137 lymphadenitis, and 114 pleuritis) were included in the analysis. Treatment was extended to more than 6 months in 58/251 (23%) patients. In the multivariate regression analysis, culture-positive EPTB (p = 0.007) [OR (95% CI) = 3.81 (1.43, 10.11)], history of diabetes (p = 0.014) [OR (95% CI) = 25.18 (1.94, 325.83)], smokeless tobacco use (p = 0.002) [OR (95% CI) = 17.69 (2.80, 111.72)], and slow regression of local signs and symptoms after 2 months of treatment (p < 0.001) [OR (95% CI) = 17.09 [(5.79, 50.39)] were seen to be significantly associated with treatment extension. Identification of predictors of extended treatment can help clinical decisions regarding optimal duration of treatment. Further studies are needed to identify subgroups of EPTB patients who can benefit from a shorter or longer treatment regimen.
format	article
author	Atiqa Ambreen Sabira Tahseen Ahmad Wali Muhammad Jamil Syed Zeeshan Haider Naqvi Nauman Safdar Tehmina Mustafa
author_facet	Atiqa Ambreen Sabira Tahseen Ahmad Wali Muhammad Jamil Syed Zeeshan Haider Naqvi Nauman Safdar Tehmina Mustafa
author_sort	Atiqa Ambreen
title	Predictors of slow clinical response and extended treatment in patients with extra-pulmonary tuberculosis in Pakistan, A hospital-based prospective study.
title_short	Predictors of slow clinical response and extended treatment in patients with extra-pulmonary tuberculosis in Pakistan, A hospital-based prospective study.
title_full	Predictors of slow clinical response and extended treatment in patients with extra-pulmonary tuberculosis in Pakistan, A hospital-based prospective study.
title_fullStr	Predictors of slow clinical response and extended treatment in patients with extra-pulmonary tuberculosis in Pakistan, A hospital-based prospective study.
title_full_unstemmed	Predictors of slow clinical response and extended treatment in patients with extra-pulmonary tuberculosis in Pakistan, A hospital-based prospective study.
title_sort	predictors of slow clinical response and extended treatment in patients with extra-pulmonary tuberculosis in pakistan, a hospital-based prospective study.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/32365d60f6f8404e9cbc29cdee830332
work_keys_str_mv	AT atiqaambreen predictorsofslowclinicalresponseandextendedtreatmentinpatientswithextrapulmonarytuberculosisinpakistanahospitalbasedprospectivestudy AT sabiratahseen predictorsofslowclinicalresponseandextendedtreatmentinpatientswithextrapulmonarytuberculosisinpakistanahospitalbasedprospectivestudy AT ahmadwali predictorsofslowclinicalresponseandextendedtreatmentinpatientswithextrapulmonarytuberculosisinpakistanahospitalbasedprospectivestudy AT muhammadjamil predictorsofslowclinicalresponseandextendedtreatmentinpatientswithextrapulmonarytuberculosisinpakistanahospitalbasedprospectivestudy AT syedzeeshanhaidernaqvi predictorsofslowclinicalresponseandextendedtreatmentinpatientswithextrapulmonarytuberculosisinpakistanahospitalbasedprospectivestudy AT naumansafdar predictorsofslowclinicalresponseandextendedtreatmentinpatientswithextrapulmonarytuberculosisinpakistanahospitalbasedprospectivestudy AT tehminamustafa predictorsofslowclinicalresponseandextendedtreatmentinpatientswithextrapulmonarytuberculosisinpakistanahospitalbasedprospectivestudy
_version_	1718374757129256960

Predictors of slow clinical response and extended treatment in patients with extra-pulmonary tuberculosis in Pakistan, A hospital-based prospective study.

Ejemplares similares