Association of Aldehyde Dehydrogenase 2 Gene Polymorphism with Myocardial Infarction
Li-Ping Zhu,1,* Wei-Lan Yin,2,* Lei Peng,1,* Xiao-Hong Zhou,3 Peng Zhou,1 Shu-Xia Xuan,1 Ying Luo,1 Chen Chen,1 Bin Cheng,1 Jin-Duan Lin,1 Yan-Mei Liu,1 Feng-Jun Tan,4 Wei-Guo Yin1,* 1Department of Molecular Diagnosis Center, The Sixth Affiliated Hospital of Guangzhou...
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Dove Medical Press
2021
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oai:doaj.org-article:3236fa1736a7447f8a316ff1dca129042021-12-02T16:40:01ZAssociation of Aldehyde Dehydrogenase 2 Gene Polymorphism with Myocardial Infarction1178-7031https://doaj.org/article/3236fa1736a7447f8a316ff1dca129042021-07-01T00:00:00Zhttps://www.dovepress.com/association-of-aldehyde-dehydrogenase-2-gene-polymorphism-with-myocard-peer-reviewed-fulltext-article-JIRhttps://doaj.org/toc/1178-7031Li-Ping Zhu,1,* Wei-Lan Yin,2,* Lei Peng,1,* Xiao-Hong Zhou,3 Peng Zhou,1 Shu-Xia Xuan,1 Ying Luo,1 Chen Chen,1 Bin Cheng,1 Jin-Duan Lin,1 Yan-Mei Liu,1 Feng-Jun Tan,4 Wei-Guo Yin1,* 1Department of Molecular Diagnosis Center, The Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan People’s Hospital, Qingyuan, 511518, Guangdong, People’s Republic of China; 2Department of Physiology & Institute of Neuroscience, University of South China, Hengyang, 421001, Hunan, People’s Republic of China; 3Kingmed Diagnostic Center for Clinical Laboratory, Guangzhou, 510330, Guangdong, People’s Republic of China; 4Department of Otorhinolaryngology, The Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan People’s Hospital, Qingyuan, 511518, Guangdong, People’s Republic of China*These authors contributed equally to this workCorrespondence: Wei-Guo YinDepartment of Molecular Diagnosis Center, The Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan People’s Hospital, No. B24, Xincheng Yinquan Road, Qingcheng District, Qingyuan, 511518, Guangdong, People’s Republic of ChinaTel +86 763 311 3890Email wgy09dr_mn@163.comObjective: This study explored the correlation between myocardial infarction (MI) and the Glu504Lys polymorphism in the aldehyde dehydrogenase 2 (ALDH2) gene in the Qingyuan area.Methods: The Glu504Lys polymorphism of the ALDH2 gene was analyzed using the polymerase chain reaction and deoxyribonucleic acid microarray analysis for 468 patients diagnosed with MI for the first time and 132 healthy subjects.Results: There was a significant difference in the distribution of the ALDH2 genotype between the MI group and the control group (P = 0.0492), but there was no significant difference in allele frequency between the two groups (P = 0.1363). The clinical data showed that there were statistically significant differences (P < 0.05) in the two groups’ gender and age distributions, rates of diabetes and hypertension, levels of alcohol and tobacco use, serological levels of heart markers, blood lipids and glucose. The subgroup analysis of ALDH2 genotypes found that alcohol consumption, high levels of myoglobin, and low levels of high-density lipoprotein cholesterol were significantly associated with a higher incidence of MI (P < 0.05). After adjusting for gender, hypertension, diabetes, and other related influencing factors, logistic regression analysis showed that the ALDH2 genotype GA/AA was an independent risk factor for MI (P < 0.05, OR = 1.479, 95% CI = 1.003– 2.179).Conclusion: The presence of risk alleles with the genetic effect (ALDH2 genotype GA/AA) is an independent risk factor for MI.Keywords: myocardial infarction, aldehyde dehydrogenase 2, polymorphismZhu LPYin WLPeng LZhou XHZhou PXuan SXLuo YChen CCheng BLin JDLiu YMTan FJYin WGDove Medical Pressarticlemyocardial infarctionaldehyde dehydrogenase 2polymorphismPathologyRB1-214Therapeutics. PharmacologyRM1-950ENJournal of Inflammation Research, Vol Volume 14, Pp 3039-3047 (2021) |
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myocardial infarction aldehyde dehydrogenase 2 polymorphism Pathology RB1-214 Therapeutics. Pharmacology RM1-950 |
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myocardial infarction aldehyde dehydrogenase 2 polymorphism Pathology RB1-214 Therapeutics. Pharmacology RM1-950 Zhu LP Yin WL Peng L Zhou XH Zhou P Xuan SX Luo Y Chen C Cheng B Lin JD Liu YM Tan FJ Yin WG Association of Aldehyde Dehydrogenase 2 Gene Polymorphism with Myocardial Infarction |
| description |
Li-Ping Zhu,1,* Wei-Lan Yin,2,* Lei Peng,1,* Xiao-Hong Zhou,3 Peng Zhou,1 Shu-Xia Xuan,1 Ying Luo,1 Chen Chen,1 Bin Cheng,1 Jin-Duan Lin,1 Yan-Mei Liu,1 Feng-Jun Tan,4 Wei-Guo Yin1,* 1Department of Molecular Diagnosis Center, The Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan People’s Hospital, Qingyuan, 511518, Guangdong, People’s Republic of China; 2Department of Physiology & Institute of Neuroscience, University of South China, Hengyang, 421001, Hunan, People’s Republic of China; 3Kingmed Diagnostic Center for Clinical Laboratory, Guangzhou, 510330, Guangdong, People’s Republic of China; 4Department of Otorhinolaryngology, The Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan People’s Hospital, Qingyuan, 511518, Guangdong, People’s Republic of China*These authors contributed equally to this workCorrespondence: Wei-Guo YinDepartment of Molecular Diagnosis Center, The Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan People’s Hospital, No. B24, Xincheng Yinquan Road, Qingcheng District, Qingyuan, 511518, Guangdong, People’s Republic of ChinaTel +86 763 311 3890Email wgy09dr_mn@163.comObjective: This study explored the correlation between myocardial infarction (MI) and the Glu504Lys polymorphism in the aldehyde dehydrogenase 2 (ALDH2) gene in the Qingyuan area.Methods: The Glu504Lys polymorphism of the ALDH2 gene was analyzed using the polymerase chain reaction and deoxyribonucleic acid microarray analysis for 468 patients diagnosed with MI for the first time and 132 healthy subjects.Results: There was a significant difference in the distribution of the ALDH2 genotype between the MI group and the control group (P = 0.0492), but there was no significant difference in allele frequency between the two groups (P = 0.1363). The clinical data showed that there were statistically significant differences (P < 0.05) in the two groups’ gender and age distributions, rates of diabetes and hypertension, levels of alcohol and tobacco use, serological levels of heart markers, blood lipids and glucose. The subgroup analysis of ALDH2 genotypes found that alcohol consumption, high levels of myoglobin, and low levels of high-density lipoprotein cholesterol were significantly associated with a higher incidence of MI (P < 0.05). After adjusting for gender, hypertension, diabetes, and other related influencing factors, logistic regression analysis showed that the ALDH2 genotype GA/AA was an independent risk factor for MI (P < 0.05, OR = 1.479, 95% CI = 1.003– 2.179).Conclusion: The presence of risk alleles with the genetic effect (ALDH2 genotype GA/AA) is an independent risk factor for MI.Keywords: myocardial infarction, aldehyde dehydrogenase 2, polymorphism |
| format |
article |
| author |
Zhu LP Yin WL Peng L Zhou XH Zhou P Xuan SX Luo Y Chen C Cheng B Lin JD Liu YM Tan FJ Yin WG |
| author_facet |
Zhu LP Yin WL Peng L Zhou XH Zhou P Xuan SX Luo Y Chen C Cheng B Lin JD Liu YM Tan FJ Yin WG |
| author_sort |
Zhu LP |
| title |
Association of Aldehyde Dehydrogenase 2 Gene Polymorphism with Myocardial Infarction |
| title_short |
Association of Aldehyde Dehydrogenase 2 Gene Polymorphism with Myocardial Infarction |
| title_full |
Association of Aldehyde Dehydrogenase 2 Gene Polymorphism with Myocardial Infarction |
| title_fullStr |
Association of Aldehyde Dehydrogenase 2 Gene Polymorphism with Myocardial Infarction |
| title_full_unstemmed |
Association of Aldehyde Dehydrogenase 2 Gene Polymorphism with Myocardial Infarction |
| title_sort |
association of aldehyde dehydrogenase 2 gene polymorphism with myocardial infarction |
| publisher |
Dove Medical Press |
| publishDate |
2021 |
| url |
https://doaj.org/article/3236fa1736a7447f8a316ff1dca12904 |
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