circRNA-0002109 promotes glioma malignant progression via modulating the miR-129-5P/EMP2 axis

Glioma is a common intracranial malignant tumor with high mortality and high recurrence rate. In recent years, increasing evidence has demonstrated that circular RNAs (circRNAs) are potential biomarkers and therapeutic targets for many tumors. However, the role of circRNAs in glioma remains unclear....

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Autores principales:	Haibin Xia, Boyang Liu, Nanxiang Shen, Jinhua Xue, Siyu Chen, Hongbo Guo, Xiaozhong Zhou
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2022
Materias:	glioma circRNA-0002109 miR-129-5P EMP2 ceRNA Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/323855b255a14ff990eb0da7d493cc5f
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spelling	oai:doaj.org-article:323855b255a14ff990eb0da7d493cc5f2021-12-04T04:33:41ZcircRNA-0002109 promotes glioma malignant progression via modulating the miR-129-5P/EMP2 axis2162-253110.1016/j.omtn.2021.11.011https://doaj.org/article/323855b255a14ff990eb0da7d493cc5f2022-03-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2162253121002869https://doaj.org/toc/2162-2531Glioma is a common intracranial malignant tumor with high mortality and high recurrence rate. In recent years, increasing evidence has demonstrated that circular RNAs (circRNAs) are potential biomarkers and therapeutic targets for many tumors. However, the role of circRNAs in glioma remains unclear. In this study, we found that circRNA-0002109 was highly expressed in glioma tissues and cell lines. Downregulation of circRNA-0002109 expression inhibited the proliferation, migration, and invasion of glioma cells and inhibited the malignant progression of tumors in vivo. Investigations into the relevant mechanisms showed that circRNA-0002109 upregulated the expression of EMP2 through endogenous competitive binding of microRNA-129-5P (miR-129-5P), which partially alleviated the inhibitory effect of miR-129-5P on epithelial membrane protein-2 (EMP2) and ultimately promoted the malignant development of glioma. Our results indicate that circRNA-0002109 plays an important role in the proliferation, invasion, and migration of glioma cells by regulating the miR-129-5P/EMP2 axis, which provides a new potential therapeutic target for glioma.Haibin XiaBoyang LiuNanxiang ShenJinhua XueSiyu ChenHongbo GuoXiaozhong ZhouElsevierarticlegliomacircRNA-0002109miR-129-5PEMP2ceRNATherapeutics. PharmacologyRM1-950ENMolecular Therapy: Nucleic Acids, Vol 27, Iss , Pp 1-15 (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	glioma circRNA-0002109 miR-129-5P EMP2 ceRNA Therapeutics. Pharmacology RM1-950
spellingShingle	glioma circRNA-0002109 miR-129-5P EMP2 ceRNA Therapeutics. Pharmacology RM1-950 Haibin Xia Boyang Liu Nanxiang Shen Jinhua Xue Siyu Chen Hongbo Guo Xiaozhong Zhou circRNA-0002109 promotes glioma malignant progression via modulating the miR-129-5P/EMP2 axis
description	Glioma is a common intracranial malignant tumor with high mortality and high recurrence rate. In recent years, increasing evidence has demonstrated that circular RNAs (circRNAs) are potential biomarkers and therapeutic targets for many tumors. However, the role of circRNAs in glioma remains unclear. In this study, we found that circRNA-0002109 was highly expressed in glioma tissues and cell lines. Downregulation of circRNA-0002109 expression inhibited the proliferation, migration, and invasion of glioma cells and inhibited the malignant progression of tumors in vivo. Investigations into the relevant mechanisms showed that circRNA-0002109 upregulated the expression of EMP2 through endogenous competitive binding of microRNA-129-5P (miR-129-5P), which partially alleviated the inhibitory effect of miR-129-5P on epithelial membrane protein-2 (EMP2) and ultimately promoted the malignant development of glioma. Our results indicate that circRNA-0002109 plays an important role in the proliferation, invasion, and migration of glioma cells by regulating the miR-129-5P/EMP2 axis, which provides a new potential therapeutic target for glioma.
format	article
author	Haibin Xia Boyang Liu Nanxiang Shen Jinhua Xue Siyu Chen Hongbo Guo Xiaozhong Zhou
author_facet	Haibin Xia Boyang Liu Nanxiang Shen Jinhua Xue Siyu Chen Hongbo Guo Xiaozhong Zhou
author_sort	Haibin Xia
title	circRNA-0002109 promotes glioma malignant progression via modulating the miR-129-5P/EMP2 axis
title_short	circRNA-0002109 promotes glioma malignant progression via modulating the miR-129-5P/EMP2 axis
title_full	circRNA-0002109 promotes glioma malignant progression via modulating the miR-129-5P/EMP2 axis
title_fullStr	circRNA-0002109 promotes glioma malignant progression via modulating the miR-129-5P/EMP2 axis
title_full_unstemmed	circRNA-0002109 promotes glioma malignant progression via modulating the miR-129-5P/EMP2 axis
title_sort	circrna-0002109 promotes glioma malignant progression via modulating the mir-129-5p/emp2 axis
publisher	Elsevier
publishDate	2022
url	https://doaj.org/article/323855b255a14ff990eb0da7d493cc5f
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circRNA-0002109 promotes glioma malignant progression via modulating the miR-129-5P/EMP2 axis

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