Early and phasic cortical metabolic changes in vestibular neuritis onset.

Functional brain activation studies described the presence of separate cortical areas responsible for central processing of peripheral vestibular information and reported their activation and interactions with other sensory modalities and the changes of this network associated to strategic periphera...

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Autores principales:	Marco Alessandrini, Marco Pagani, Bianca Napolitano, Alessandro Micarelli, Matteo Candidi, Ernesto Bruno, Agostino Chiaravalloti, Barbara Di Pietro, Orazio Schillaci
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/32399dfa681244118aca055799245627
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spelling	oai:doaj.org-article:32399dfa681244118aca0557992456272021-11-18T07:54:27ZEarly and phasic cortical metabolic changes in vestibular neuritis onset.1932-620310.1371/journal.pone.0057596https://doaj.org/article/32399dfa681244118aca0557992456272013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23505435/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Functional brain activation studies described the presence of separate cortical areas responsible for central processing of peripheral vestibular information and reported their activation and interactions with other sensory modalities and the changes of this network associated to strategic peripheral or central vestibular lesions. It is already known that cortical changes induced by acute unilateral vestibular failure (UVF) are various and undergo variations over time, revealing different cortical involved areas at the onset and recovery from symptoms. The present study aimed at reporting the earliest change in cortical metabolic activity during a paradigmatic form of UVF such as vestibular neuritis (VN), that is, a purely peripheral lesion of the vestibular system, that offers the opportunity to study the cortical response to altered vestibular processing. This research reports [(18)F]fluorodeoxyglucose positron emission tomography brain scan data concerning the early cortical metabolic activity associated to symptoms onset in a group of eight patients suffering from VN. VN patients' cortical metabolic activity during the first two days from symptoms onset was compared to that recorded one month later and to a control healthy group. Beside the known cortical response in the sensorimotor network associated to vestibular deafferentation, we show for the first time the involvement of Entorhinal (BAs 28, 34) and Temporal (BA 38) cortices in early phases of symptomatology onset. We interpret these findings as the cortical counterparts of the attempt to reorient oneself in space counteracting the vertigo symptom (Bas 28, 34) and of the emotional response to the new pathologic condition (BA 38) respectively. These interpretations were further supported by changes in patients' subjective ratings in balance, anxiety, and depersonalization/derealization scores when tested at illness onset and one month later. The present findings contribute in expanding knowledge about early, fast-changing, and complex cortical responses to pathological vestibular unbalanced processing.Marco AlessandriniMarco PaganiBianca NapolitanoAlessandro MicarelliMatteo CandidiErnesto BrunoAgostino ChiaravallotiBarbara Di PietroOrazio SchillaciPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 3, p e57596 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Marco Alessandrini Marco Pagani Bianca Napolitano Alessandro Micarelli Matteo Candidi Ernesto Bruno Agostino Chiaravalloti Barbara Di Pietro Orazio Schillaci Early and phasic cortical metabolic changes in vestibular neuritis onset.
description	Functional brain activation studies described the presence of separate cortical areas responsible for central processing of peripheral vestibular information and reported their activation and interactions with other sensory modalities and the changes of this network associated to strategic peripheral or central vestibular lesions. It is already known that cortical changes induced by acute unilateral vestibular failure (UVF) are various and undergo variations over time, revealing different cortical involved areas at the onset and recovery from symptoms. The present study aimed at reporting the earliest change in cortical metabolic activity during a paradigmatic form of UVF such as vestibular neuritis (VN), that is, a purely peripheral lesion of the vestibular system, that offers the opportunity to study the cortical response to altered vestibular processing. This research reports [(18)F]fluorodeoxyglucose positron emission tomography brain scan data concerning the early cortical metabolic activity associated to symptoms onset in a group of eight patients suffering from VN. VN patients' cortical metabolic activity during the first two days from symptoms onset was compared to that recorded one month later and to a control healthy group. Beside the known cortical response in the sensorimotor network associated to vestibular deafferentation, we show for the first time the involvement of Entorhinal (BAs 28, 34) and Temporal (BA 38) cortices in early phases of symptomatology onset. We interpret these findings as the cortical counterparts of the attempt to reorient oneself in space counteracting the vertigo symptom (Bas 28, 34) and of the emotional response to the new pathologic condition (BA 38) respectively. These interpretations were further supported by changes in patients' subjective ratings in balance, anxiety, and depersonalization/derealization scores when tested at illness onset and one month later. The present findings contribute in expanding knowledge about early, fast-changing, and complex cortical responses to pathological vestibular unbalanced processing.
format	article
author	Marco Alessandrini Marco Pagani Bianca Napolitano Alessandro Micarelli Matteo Candidi Ernesto Bruno Agostino Chiaravalloti Barbara Di Pietro Orazio Schillaci
author_facet	Marco Alessandrini Marco Pagani Bianca Napolitano Alessandro Micarelli Matteo Candidi Ernesto Bruno Agostino Chiaravalloti Barbara Di Pietro Orazio Schillaci
author_sort	Marco Alessandrini
title	Early and phasic cortical metabolic changes in vestibular neuritis onset.
title_short	Early and phasic cortical metabolic changes in vestibular neuritis onset.
title_full	Early and phasic cortical metabolic changes in vestibular neuritis onset.
title_fullStr	Early and phasic cortical metabolic changes in vestibular neuritis onset.
title_full_unstemmed	Early and phasic cortical metabolic changes in vestibular neuritis onset.
title_sort	early and phasic cortical metabolic changes in vestibular neuritis onset.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/32399dfa681244118aca055799245627
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_version_	1718422776872697856

Early and phasic cortical metabolic changes in vestibular neuritis onset.

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