The Cytotoxic Effect of Copper (II) Complexes with Halogenated 1,3-Disubstituted Arylthioureas on Cancer and Bacterial Cells

A series of eight copper (II) complexes with 3-(4-chloro-3-nitrophenyl)thiourea were designed and synthesized. The cytotoxic activity of all compounds was assessed in three human cancer cell lines (SW480, SW620, PC3) and human normal keratinocytes (HaCaT). The complexes <b>1</b>, <b&g...

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Autores principales:	Alicja Chrzanowska, Aleksandra Drzewiecka-Antonik, Katarzyna Dobrzyńska, Joanna Stefańska, Piotr Pietrzyk, Marta Struga, Anna Bielenica
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	copper (II) complexes thiourea cytotoxic activity proteome analysis antimicrobial activity Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/323bb69078a04374a831b89c811af008
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spelling	oai:doaj.org-article:323bb69078a04374a831b89c811af0082021-11-11T16:53:12ZThe Cytotoxic Effect of Copper (II) Complexes with Halogenated 1,3-Disubstituted Arylthioureas on Cancer and Bacterial Cells10.3390/ijms2221114151422-00671661-6596https://doaj.org/article/323bb69078a04374a831b89c811af0082021-10-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/11415https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067A series of eight copper (II) complexes with 3-(4-chloro-3-nitrophenyl)thiourea were designed and synthesized. The cytotoxic activity of all compounds was assessed in three human cancer cell lines (SW480, SW620, PC3) and human normal keratinocytes (HaCaT). The complexes <b>1</b>, <b>3</b>, <b>5</b>, <b>7</b> and <b>8</b> were cytotoxic to the studied tumor cells in the low micromolar range, without affecting the normal cells. The complexes <b>1</b>, <b>3</b>, <b>7</b> and <b>8</b> induced lactate dehydrogenase (LDH) release in all cancer cell lines, but not in the HaCaT cells. They provoked early apoptosis in pathological cells, especially in SW480 and PC3 cells. The ability of compounds <b>1</b>, <b>3</b>, <b>7</b> and <b>8</b> to diminish interleukin-6 (IL-6) concentration in a cell was established. For the first time, the influence of the most promising Cu (II) complexes on intensities of detoxifying and reactive oxygen species (ROS) scavenging the enzymes of tumor cells was studied. The cytotoxic effect of all copper (II) conjugates against standard and hospital bacterial strains was also proved.Alicja ChrzanowskaAleksandra Drzewiecka-AntonikKatarzyna DobrzyńskaJoanna StefańskaPiotr PietrzykMarta StrugaAnna BielenicaMDPI AGarticlecopper (II) complexesthioureacytotoxic activityproteome analysisantimicrobial activityBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 11415, p 11415 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	copper (II) complexes thiourea cytotoxic activity proteome analysis antimicrobial activity Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	copper (II) complexes thiourea cytotoxic activity proteome analysis antimicrobial activity Biology (General) QH301-705.5 Chemistry QD1-999 Alicja Chrzanowska Aleksandra Drzewiecka-Antonik Katarzyna Dobrzyńska Joanna Stefańska Piotr Pietrzyk Marta Struga Anna Bielenica The Cytotoxic Effect of Copper (II) Complexes with Halogenated 1,3-Disubstituted Arylthioureas on Cancer and Bacterial Cells
description	A series of eight copper (II) complexes with 3-(4-chloro-3-nitrophenyl)thiourea were designed and synthesized. The cytotoxic activity of all compounds was assessed in three human cancer cell lines (SW480, SW620, PC3) and human normal keratinocytes (HaCaT). The complexes <b>1</b>, <b>3</b>, <b>5</b>, <b>7</b> and <b>8</b> were cytotoxic to the studied tumor cells in the low micromolar range, without affecting the normal cells. The complexes <b>1</b>, <b>3</b>, <b>7</b> and <b>8</b> induced lactate dehydrogenase (LDH) release in all cancer cell lines, but not in the HaCaT cells. They provoked early apoptosis in pathological cells, especially in SW480 and PC3 cells. The ability of compounds <b>1</b>, <b>3</b>, <b>7</b> and <b>8</b> to diminish interleukin-6 (IL-6) concentration in a cell was established. For the first time, the influence of the most promising Cu (II) complexes on intensities of detoxifying and reactive oxygen species (ROS) scavenging the enzymes of tumor cells was studied. The cytotoxic effect of all copper (II) conjugates against standard and hospital bacterial strains was also proved.
format	article
author	Alicja Chrzanowska Aleksandra Drzewiecka-Antonik Katarzyna Dobrzyńska Joanna Stefańska Piotr Pietrzyk Marta Struga Anna Bielenica
author_facet	Alicja Chrzanowska Aleksandra Drzewiecka-Antonik Katarzyna Dobrzyńska Joanna Stefańska Piotr Pietrzyk Marta Struga Anna Bielenica
author_sort	Alicja Chrzanowska
title	The Cytotoxic Effect of Copper (II) Complexes with Halogenated 1,3-Disubstituted Arylthioureas on Cancer and Bacterial Cells
title_short	The Cytotoxic Effect of Copper (II) Complexes with Halogenated 1,3-Disubstituted Arylthioureas on Cancer and Bacterial Cells
title_full	The Cytotoxic Effect of Copper (II) Complexes with Halogenated 1,3-Disubstituted Arylthioureas on Cancer and Bacterial Cells
title_fullStr	The Cytotoxic Effect of Copper (II) Complexes with Halogenated 1,3-Disubstituted Arylthioureas on Cancer and Bacterial Cells
title_full_unstemmed	The Cytotoxic Effect of Copper (II) Complexes with Halogenated 1,3-Disubstituted Arylthioureas on Cancer and Bacterial Cells
title_sort	cytotoxic effect of copper (ii) complexes with halogenated 1,3-disubstituted arylthioureas on cancer and bacterial cells
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/323bb69078a04374a831b89c811af008
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The Cytotoxic Effect of Copper (II) Complexes with Halogenated 1,3-Disubstituted Arylthioureas on Cancer and Bacterial Cells

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