Sexually dimorphic leanness and hypermobility in p16 Ink4a /CDKN2A-deficient mice coincides with phenotypic changes in the cerebellum
Abstract p16 Ink4a /CDKN2A is a tumor suppressor that critically regulates the cell cycle. Indeed, p16 Ink4a deficiency promotes tumor formation in various tissues. We now report that p16 Ink4a deficiency in female mice, but not male mice, induces leanness especially in old age, as indicated by lowe...
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| Main Authors: | , , , , , , , , |
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| Format: | article |
| Language: | EN |
| Published: |
Nature Portfolio
2019
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| Subjects: | |
| Online Access: | https://doaj.org/article/323f75e31e8349f98e967ae959e242b5 |
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