Richer gut microbiota with distinct metabolic profile in HIV infected Elite Controllers

Abstract Gut microbiota dysbiosis features progressive HIV infection and is a potential target for intervention. Herein, we explored the microbiome of 16 elite controllers (EC), 32 antiretroviral therapy naive progressors and 16 HIV negative controls. We found that the number of observed genera and...

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Autores principales:	Jan Vesterbacka, Javier Rivera, Kajsa Noyan, Mariona Parera, Ujjwal Neogi, Malu Calle, Roger Paredes, Anders Sönnerborg, Marc Noguera-Julian, Piotr Nowak
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/32420ccddfc246758828015541597324
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spelling	oai:doaj.org-article:32420ccddfc2467588280155415973242021-12-02T12:31:53ZRicher gut microbiota with distinct metabolic profile in HIV infected Elite Controllers10.1038/s41598-017-06675-12045-2322https://doaj.org/article/32420ccddfc2467588280155415973242017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-06675-1https://doaj.org/toc/2045-2322Abstract Gut microbiota dysbiosis features progressive HIV infection and is a potential target for intervention. Herein, we explored the microbiome of 16 elite controllers (EC), 32 antiretroviral therapy naive progressors and 16 HIV negative controls. We found that the number of observed genera and richness indices in fecal microbiota were significantly higher in EC versus naive. Genera Succinivibrio, Sutterella, Rhizobium, Delftia, Anaerofilum and Oscillospira were more abundant in EC, whereas Blautia and Anaerostipes were depleted. Additionally, carbohydrate metabolism and secondary bile acid synthesis pathway related genes were less represented in EC. Conversely, fatty acid metabolism, PPAR-signalling and lipid biosynthesis proteins pathways were enriched in EC vs naive. The kynurenine pathway of tryptophan metabolism was altered during progressive HIV infection, and inversely associated with microbiota richness. In conclusion, EC have richer gut microbiota than untreated HIV patients, with unique bacterial signatures and a distinct metabolic profile which may contribute to control of HIV.Jan VesterbackaJavier RiveraKajsa NoyanMariona PareraUjjwal NeogiMalu CalleRoger ParedesAnders SönnerborgMarc Noguera-JulianPiotr NowakNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jan Vesterbacka Javier Rivera Kajsa Noyan Mariona Parera Ujjwal Neogi Malu Calle Roger Paredes Anders Sönnerborg Marc Noguera-Julian Piotr Nowak Richer gut microbiota with distinct metabolic profile in HIV infected Elite Controllers
description	Abstract Gut microbiota dysbiosis features progressive HIV infection and is a potential target for intervention. Herein, we explored the microbiome of 16 elite controllers (EC), 32 antiretroviral therapy naive progressors and 16 HIV negative controls. We found that the number of observed genera and richness indices in fecal microbiota were significantly higher in EC versus naive. Genera Succinivibrio, Sutterella, Rhizobium, Delftia, Anaerofilum and Oscillospira were more abundant in EC, whereas Blautia and Anaerostipes were depleted. Additionally, carbohydrate metabolism and secondary bile acid synthesis pathway related genes were less represented in EC. Conversely, fatty acid metabolism, PPAR-signalling and lipid biosynthesis proteins pathways were enriched in EC vs naive. The kynurenine pathway of tryptophan metabolism was altered during progressive HIV infection, and inversely associated with microbiota richness. In conclusion, EC have richer gut microbiota than untreated HIV patients, with unique bacterial signatures and a distinct metabolic profile which may contribute to control of HIV.
format	article
author	Jan Vesterbacka Javier Rivera Kajsa Noyan Mariona Parera Ujjwal Neogi Malu Calle Roger Paredes Anders Sönnerborg Marc Noguera-Julian Piotr Nowak
author_facet	Jan Vesterbacka Javier Rivera Kajsa Noyan Mariona Parera Ujjwal Neogi Malu Calle Roger Paredes Anders Sönnerborg Marc Noguera-Julian Piotr Nowak
author_sort	Jan Vesterbacka
title	Richer gut microbiota with distinct metabolic profile in HIV infected Elite Controllers
title_short	Richer gut microbiota with distinct metabolic profile in HIV infected Elite Controllers
title_full	Richer gut microbiota with distinct metabolic profile in HIV infected Elite Controllers
title_fullStr	Richer gut microbiota with distinct metabolic profile in HIV infected Elite Controllers
title_full_unstemmed	Richer gut microbiota with distinct metabolic profile in HIV infected Elite Controllers
title_sort	richer gut microbiota with distinct metabolic profile in hiv infected elite controllers
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/32420ccddfc246758828015541597324
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Richer gut microbiota with distinct metabolic profile in HIV infected Elite Controllers

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