Clique of functional hubs orchestrates population bursts in developmentally regulated neural networks.

It has recently been discovered that single neuron stimulation can impact network dynamics in immature and adult neuronal circuits. Here we report a novel mechanism which can explain in neuronal circuits, at an early stage of development, the peculiar role played by a few specific neurons in promoti...

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Autores principales:	Stefano Luccioli, Eshel Ben-Jacob, Ari Barzilai, Paolo Bonifazi, Alessandro Torcini
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/3242aad00437447ba35efc147e4c37f5
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spelling	oai:doaj.org-article:3242aad00437447ba35efc147e4c37f52021-11-25T05:40:43ZClique of functional hubs orchestrates population bursts in developmentally regulated neural networks.1553-734X1553-735810.1371/journal.pcbi.1003823https://doaj.org/article/3242aad00437447ba35efc147e4c37f52014-09-01T00:00:00Zhttps://doi.org/10.1371/journal.pcbi.1003823https://doaj.org/toc/1553-734Xhttps://doaj.org/toc/1553-7358It has recently been discovered that single neuron stimulation can impact network dynamics in immature and adult neuronal circuits. Here we report a novel mechanism which can explain in neuronal circuits, at an early stage of development, the peculiar role played by a few specific neurons in promoting/arresting the population activity. For this purpose, we consider a standard neuronal network model, with short-term synaptic plasticity, whose population activity is characterized by bursting behavior. The addition of developmentally inspired constraints and correlations in the distribution of the neuronal connectivities and excitabilities leads to the emergence of functional hub neurons, whose stimulation/deletion is critical for the network activity. Functional hubs form a clique, where a precise sequential activation of the neurons is essential to ignite collective events without any need for a specific topological architecture. Unsupervised time-lagged firings of supra-threshold cells, in connection with coordinated entrainments of near-threshold neurons, are the key ingredients to orchestrate population activity.Stefano LuccioliEshel Ben-JacobAri BarzilaiPaolo BonifaziAlessandro TorciniPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Computational Biology, Vol 10, Iss 9, p e1003823 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Stefano Luccioli Eshel Ben-Jacob Ari Barzilai Paolo Bonifazi Alessandro Torcini Clique of functional hubs orchestrates population bursts in developmentally regulated neural networks.
description	It has recently been discovered that single neuron stimulation can impact network dynamics in immature and adult neuronal circuits. Here we report a novel mechanism which can explain in neuronal circuits, at an early stage of development, the peculiar role played by a few specific neurons in promoting/arresting the population activity. For this purpose, we consider a standard neuronal network model, with short-term synaptic plasticity, whose population activity is characterized by bursting behavior. The addition of developmentally inspired constraints and correlations in the distribution of the neuronal connectivities and excitabilities leads to the emergence of functional hub neurons, whose stimulation/deletion is critical for the network activity. Functional hubs form a clique, where a precise sequential activation of the neurons is essential to ignite collective events without any need for a specific topological architecture. Unsupervised time-lagged firings of supra-threshold cells, in connection with coordinated entrainments of near-threshold neurons, are the key ingredients to orchestrate population activity.
format	article
author	Stefano Luccioli Eshel Ben-Jacob Ari Barzilai Paolo Bonifazi Alessandro Torcini
author_facet	Stefano Luccioli Eshel Ben-Jacob Ari Barzilai Paolo Bonifazi Alessandro Torcini
author_sort	Stefano Luccioli
title	Clique of functional hubs orchestrates population bursts in developmentally regulated neural networks.
title_short	Clique of functional hubs orchestrates population bursts in developmentally regulated neural networks.
title_full	Clique of functional hubs orchestrates population bursts in developmentally regulated neural networks.
title_fullStr	Clique of functional hubs orchestrates population bursts in developmentally regulated neural networks.
title_full_unstemmed	Clique of functional hubs orchestrates population bursts in developmentally regulated neural networks.
title_sort	clique of functional hubs orchestrates population bursts in developmentally regulated neural networks.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/3242aad00437447ba35efc147e4c37f5
work_keys_str_mv	AT stefanoluccioli cliqueoffunctionalhubsorchestratespopulationburstsindevelopmentallyregulatedneuralnetworks AT eshelbenjacob cliqueoffunctionalhubsorchestratespopulationburstsindevelopmentallyregulatedneuralnetworks AT aribarzilai cliqueoffunctionalhubsorchestratespopulationburstsindevelopmentallyregulatedneuralnetworks AT paolobonifazi cliqueoffunctionalhubsorchestratespopulationburstsindevelopmentallyregulatedneuralnetworks AT alessandrotorcini cliqueoffunctionalhubsorchestratespopulationburstsindevelopmentallyregulatedneuralnetworks
_version_	1718414509947748352

Clique of functional hubs orchestrates population bursts in developmentally regulated neural networks.

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