Effect of Different Doses of Curcumin on Sperm Parameters and Oxidative Stress in Testis of D-Galactose Induced Aging Mice Model

BACKGROUND AND OBJECTIVE: Aging is accompanied with low concentration of testosterone hormone and apoptosis induction in the testis. The aim of this research was to investigate the effects of different doses of curcumin as the active ingredient of Curcuma Longa Turmeric, on sperm quality and oxidati...

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Autores principales:	M Yousefi, Sh Mohammadi, M Jalali, F Beheshti
Formato:	article
Lenguaje:	EN FA
Publicado:	Babol University of Medical Sciences 2019
Materias:	curcumin aging sperm mice. Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/3246c70c0b2743778a846d2ec7ecab3f
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spelling	oai:doaj.org-article:3246c70c0b2743778a846d2ec7ecab3f2021-11-10T08:30:36ZEffect of Different Doses of Curcumin on Sperm Parameters and Oxidative Stress in Testis of D-Galactose Induced Aging Mice Model1561-41072251-7170https://doaj.org/article/3246c70c0b2743778a846d2ec7ecab3f2019-12-01T00:00:00Zhttp://jbums.org/article-1-8023-en.htmlhttps://doaj.org/toc/1561-4107https://doaj.org/toc/2251-7170BACKGROUND AND OBJECTIVE: Aging is accompanied with low concentration of testosterone hormone and apoptosis induction in the testis. The aim of this research was to investigate the effects of different doses of curcumin as the active ingredient of Curcuma Longa Turmeric, on sperm quality and oxidative stress in mice D-galactose-induced aging model. METHODS: 48 Balb/c mice (n=8) were randomly assigned to 6 groups: control, Sham, D-galactose and Curcumin 1 to 3 groups. 300 mg/kg of D-galactose was injected to D-galactose group. Curcumin 1 to 3 were injected D-galactose + 25, 50 and 100 mg/kg curcumin intraperitoneally. Then, the oxidative stress based on biochemical parameters and sperm analysis according to WHO guideline were evaluated on day 42 of the experiment. FINDINGS: Mean sperm count in control group was (4.17±0.84) while it reduced after reception of 300 mg/kg D-galactose (3.06±0.86). There was a significant increase in the sperm parameters in Curcumin group compared to the D-galactose group (p<0.05). A significant increase was observed in the level of thiol and superoxide dismutase enzyme in curcumin group 3, compared to the D-galactose group (p≤0.001). Significant decreases in catalase and malondialdehyde enzymes were observed in the D-galactose group, compared to the curcumin 1, curcumin 2 and curcumin 3 groups (p<0.05). CONCLUSION: Administration of curcumin for 2 weeks improved sperm parameters and decreased oxidative stress in testis of mice D-galactose-induced aging model.M YousefiSh MohammadiM JalaliF BeheshtiBabol University of Medical Sciencesarticlecurcuminagingspermmice.MedicineRMedicine (General)R5-920ENFAMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 21, Iss 1, Pp 53-60 (2019)
institution	DOAJ
collection	DOAJ
language	EN FA
topic	curcumin aging sperm mice. Medicine R Medicine (General) R5-920
spellingShingle	curcumin aging sperm mice. Medicine R Medicine (General) R5-920 M Yousefi Sh Mohammadi M Jalali F Beheshti Effect of Different Doses of Curcumin on Sperm Parameters and Oxidative Stress in Testis of D-Galactose Induced Aging Mice Model
description	BACKGROUND AND OBJECTIVE: Aging is accompanied with low concentration of testosterone hormone and apoptosis induction in the testis. The aim of this research was to investigate the effects of different doses of curcumin as the active ingredient of Curcuma Longa Turmeric, on sperm quality and oxidative stress in mice D-galactose-induced aging model. METHODS: 48 Balb/c mice (n=8) were randomly assigned to 6 groups: control, Sham, D-galactose and Curcumin 1 to 3 groups. 300 mg/kg of D-galactose was injected to D-galactose group. Curcumin 1 to 3 were injected D-galactose + 25, 50 and 100 mg/kg curcumin intraperitoneally. Then, the oxidative stress based on biochemical parameters and sperm analysis according to WHO guideline were evaluated on day 42 of the experiment. FINDINGS: Mean sperm count in control group was (4.17±0.84) while it reduced after reception of 300 mg/kg D-galactose (3.06±0.86). There was a significant increase in the sperm parameters in Curcumin group compared to the D-galactose group (p<0.05). A significant increase was observed in the level of thiol and superoxide dismutase enzyme in curcumin group 3, compared to the D-galactose group (p≤0.001). Significant decreases in catalase and malondialdehyde enzymes were observed in the D-galactose group, compared to the curcumin 1, curcumin 2 and curcumin 3 groups (p<0.05). CONCLUSION: Administration of curcumin for 2 weeks improved sperm parameters and decreased oxidative stress in testis of mice D-galactose-induced aging model.
format	article
author	M Yousefi Sh Mohammadi M Jalali F Beheshti
author_facet	M Yousefi Sh Mohammadi M Jalali F Beheshti
author_sort	M Yousefi
title	Effect of Different Doses of Curcumin on Sperm Parameters and Oxidative Stress in Testis of D-Galactose Induced Aging Mice Model
title_short	Effect of Different Doses of Curcumin on Sperm Parameters and Oxidative Stress in Testis of D-Galactose Induced Aging Mice Model
title_full	Effect of Different Doses of Curcumin on Sperm Parameters and Oxidative Stress in Testis of D-Galactose Induced Aging Mice Model
title_fullStr	Effect of Different Doses of Curcumin on Sperm Parameters and Oxidative Stress in Testis of D-Galactose Induced Aging Mice Model
title_full_unstemmed	Effect of Different Doses of Curcumin on Sperm Parameters and Oxidative Stress in Testis of D-Galactose Induced Aging Mice Model
title_sort	effect of different doses of curcumin on sperm parameters and oxidative stress in testis of d-galactose induced aging mice model
publisher	Babol University of Medical Sciences
publishDate	2019
url	https://doaj.org/article/3246c70c0b2743778a846d2ec7ecab3f
work_keys_str_mv	AT myousefi effectofdifferentdosesofcurcuminonspermparametersandoxidativestressintestisofdgalactoseinducedagingmicemodel AT shmohammadi effectofdifferentdosesofcurcuminonspermparametersandoxidativestressintestisofdgalactoseinducedagingmicemodel AT mjalali effectofdifferentdosesofcurcuminonspermparametersandoxidativestressintestisofdgalactoseinducedagingmicemodel AT fbeheshti effectofdifferentdosesofcurcuminonspermparametersandoxidativestressintestisofdgalactoseinducedagingmicemodel
_version_	1718440361047621632

Effect of Different Doses of Curcumin on Sperm Parameters and Oxidative Stress in Testis of D-Galactose Induced Aging Mice Model

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