Fibroblast-enriched endoplasmic reticulum protein TXNDC5 promotes pulmonary fibrosis by augmenting TGFβ signaling through TGFBR1 stabilization

Fibroblast-enriched endoplasmic reticulum protein TXNDC5 promotes pulmonary fibrosis by augmenting TGFβ signaling through TGFBR1 stabilization

Pulmonary fibrosis is a major public health problem with unclear mechanism and limited therapeutic options. Here the authors show that a fibroblast-enriched endoplasmic reticulum protein, TXNDC5, promotes pulmonary fibrosis by stabilizing TGFBR1 and show the potential of TXNDC5 as a therapeutic targ...

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Autores principales: Tzu-Han Lee, Chih-Fan Yeh, Ying-Tung Lee, Ying-Chun Shih, Yen-Ting Chen, Chen-Ting Hung, Ming-Yi You, Pei-Chen Wu, Tzu-Pin Shentu, Ru-Ting Huang, Yu-Shan Lin, Yueh-Feng Wu, Sung-Jan Lin, Frank-Leigh Lu, Po-Nien Tsao, Tzu-Hung Lin, Shen-Chuan Lo, Yi-Shuan Tseng, Wan-Lin Wu, Chiung-Nien Chen, Chau-Chung Wu, Shuei-Liong Lin, Anne I. Sperling, Robert D. Guzy, Yun Fang, Kai-Chien Yang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/3247641fb8bc4b9a922458d050d87b61
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spelling oai:doaj.org-article:3247641fb8bc4b9a922458d050d87b612021-12-02T19:02:33ZFibroblast-enriched endoplasmic reticulum protein TXNDC5 promotes pulmonary fibrosis by augmenting TGFβ signaling through TGFBR1 stabilization10.1038/s41467-020-18047-x2041-1723https://doaj.org/article/3247641fb8bc4b9a922458d050d87b612020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18047-xhttps://doaj.org/toc/2041-1723Pulmonary fibrosis is a major public health problem with unclear mechanism and limited therapeutic options. Here the authors show that a fibroblast-enriched endoplasmic reticulum protein, TXNDC5, promotes pulmonary fibrosis by stabilizing TGFBR1 and show the potential of TXNDC5 as a therapeutic target against pulmonary fibrosis.Tzu-Han LeeChih-Fan YehYing-Tung LeeYing-Chun ShihYen-Ting ChenChen-Ting HungMing-Yi YouPei-Chen WuTzu-Pin ShentuRu-Ting HuangYu-Shan LinYueh-Feng WuSung-Jan LinFrank-Leigh LuPo-Nien TsaoTzu-Hung LinShen-Chuan LoYi-Shuan TsengWan-Lin WuChiung-Nien ChenChau-Chung WuShuei-Liong LinAnne I. SperlingRobert D. GuzyYun FangKai-Chien YangNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-20 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Tzu-Han Lee
Chih-Fan Yeh
Ying-Tung Lee
Ying-Chun Shih
Yen-Ting Chen
Chen-Ting Hung
Ming-Yi You
Pei-Chen Wu
Tzu-Pin Shentu
Ru-Ting Huang
Yu-Shan Lin
Yueh-Feng Wu
Sung-Jan Lin
Frank-Leigh Lu
Po-Nien Tsao
Tzu-Hung Lin
Shen-Chuan Lo
Yi-Shuan Tseng
Wan-Lin Wu
Chiung-Nien Chen
Chau-Chung Wu
Shuei-Liong Lin
Anne I. Sperling
Robert D. Guzy
Yun Fang
Kai-Chien Yang
Fibroblast-enriched endoplasmic reticulum protein TXNDC5 promotes pulmonary fibrosis by augmenting TGFβ signaling through TGFBR1 stabilization
description Pulmonary fibrosis is a major public health problem with unclear mechanism and limited therapeutic options. Here the authors show that a fibroblast-enriched endoplasmic reticulum protein, TXNDC5, promotes pulmonary fibrosis by stabilizing TGFBR1 and show the potential of TXNDC5 as a therapeutic target against pulmonary fibrosis.
format article
author Tzu-Han Lee
Chih-Fan Yeh
Ying-Tung Lee
Ying-Chun Shih
Yen-Ting Chen
Chen-Ting Hung
Ming-Yi You
Pei-Chen Wu
Tzu-Pin Shentu
Ru-Ting Huang
Yu-Shan Lin
Yueh-Feng Wu
Sung-Jan Lin
Frank-Leigh Lu
Po-Nien Tsao
Tzu-Hung Lin
Shen-Chuan Lo
Yi-Shuan Tseng
Wan-Lin Wu
Chiung-Nien Chen
Chau-Chung Wu
Shuei-Liong Lin
Anne I. Sperling
Robert D. Guzy
Yun Fang
Kai-Chien Yang
author_facet Tzu-Han Lee
Chih-Fan Yeh
Ying-Tung Lee
Ying-Chun Shih
Yen-Ting Chen
Chen-Ting Hung
Ming-Yi You
Pei-Chen Wu
Tzu-Pin Shentu
Ru-Ting Huang
Yu-Shan Lin
Yueh-Feng Wu
Sung-Jan Lin
Frank-Leigh Lu
Po-Nien Tsao
Tzu-Hung Lin
Shen-Chuan Lo
Yi-Shuan Tseng
Wan-Lin Wu
Chiung-Nien Chen
Chau-Chung Wu
Shuei-Liong Lin
Anne I. Sperling
Robert D. Guzy
Yun Fang
Kai-Chien Yang
author_sort Tzu-Han Lee
title Fibroblast-enriched endoplasmic reticulum protein TXNDC5 promotes pulmonary fibrosis by augmenting TGFβ signaling through TGFBR1 stabilization
title_short Fibroblast-enriched endoplasmic reticulum protein TXNDC5 promotes pulmonary fibrosis by augmenting TGFβ signaling through TGFBR1 stabilization
title_full Fibroblast-enriched endoplasmic reticulum protein TXNDC5 promotes pulmonary fibrosis by augmenting TGFβ signaling through TGFBR1 stabilization
title_fullStr Fibroblast-enriched endoplasmic reticulum protein TXNDC5 promotes pulmonary fibrosis by augmenting TGFβ signaling through TGFBR1 stabilization
title_full_unstemmed Fibroblast-enriched endoplasmic reticulum protein TXNDC5 promotes pulmonary fibrosis by augmenting TGFβ signaling through TGFBR1 stabilization
title_sort fibroblast-enriched endoplasmic reticulum protein txndc5 promotes pulmonary fibrosis by augmenting tgfβ signaling through tgfbr1 stabilization
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/3247641fb8bc4b9a922458d050d87b61
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