Depression and Catechol-O-methyltransferase (COMT) genetic variants are associated with pain in Parkinson’s disease

Abstract Pain is a distressing symptom of Parkinson disease (PD). We aim to determine whether the genetic variants of chronic pain-related genes contribute to pain in PD patients. We included 418 PD patients and evaluated pain severity on King’s PD pain scale. We genotyped rs6267, rs6269, rs4633, rs...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Chin-Hsien Lin, K. Ray Chaudhuri, Jun-Yu Fan, Chia-I. Ko, Alexandra Rizos, Chia-Wen Chang, Han-I. Lin, Yih-Ru Wu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3247aecccc8a4ab2985b8fdc66899e51
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:3247aecccc8a4ab2985b8fdc66899e51
record_format	dspace
spelling	oai:doaj.org-article:3247aecccc8a4ab2985b8fdc66899e512021-12-02T12:31:50ZDepression and Catechol-O-methyltransferase (COMT) genetic variants are associated with pain in Parkinson’s disease10.1038/s41598-017-06782-z2045-2322https://doaj.org/article/3247aecccc8a4ab2985b8fdc66899e512017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-06782-zhttps://doaj.org/toc/2045-2322Abstract Pain is a distressing symptom of Parkinson disease (PD). We aim to determine whether the genetic variants of chronic pain-related genes contribute to pain in PD patients. We included 418 PD patients and evaluated pain severity on King’s PD pain scale. We genotyped rs6267, rs6269, rs4633, rs4818 and rs4680 of COMT, rs6746030 of SCN9A, and rs1799971 of OPRM1. In total, 193 participants (46.2%) experienced pain. Compared to pain-free PD patients, PD patients with pain had an earlier age of onset, longer disease duration, and higher depression and motor severity (P < 0.01). The frequencies of COMT rs4680 “A” allele were higher in PD patients with pain than those without pain (46.1% vs. 31.1%, P < 0.01). Pain severity was significantly associated with disease duration (P = 0.02), and COMT rs6267 T allele (P < 0.01). We stratified PD by status of depression and the association between COMT rs6267 “GT” genotype and pain severity remained significant (P < 0.01). Furthermore, pain severity was significantly higher in participants having COMT rs4680 “GG” and “GA” genpotypes than those having “AA” genotype (P = 0.04). We concluded that depression and COMT rs4680 “GG” and “GA” genotypes and COMT rs6267 “GT” genotype contribute to pain in PD patients.Chin-Hsien LinK. Ray ChaudhuriJun-Yu FanChia-I. KoAlexandra RizosChia-Wen ChangHan-I. LinYih-Ru WuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Chin-Hsien Lin K. Ray Chaudhuri Jun-Yu Fan Chia-I. Ko Alexandra Rizos Chia-Wen Chang Han-I. Lin Yih-Ru Wu Depression and Catechol-O-methyltransferase (COMT) genetic variants are associated with pain in Parkinson’s disease
description	Abstract Pain is a distressing symptom of Parkinson disease (PD). We aim to determine whether the genetic variants of chronic pain-related genes contribute to pain in PD patients. We included 418 PD patients and evaluated pain severity on King’s PD pain scale. We genotyped rs6267, rs6269, rs4633, rs4818 and rs4680 of COMT, rs6746030 of SCN9A, and rs1799971 of OPRM1. In total, 193 participants (46.2%) experienced pain. Compared to pain-free PD patients, PD patients with pain had an earlier age of onset, longer disease duration, and higher depression and motor severity (P < 0.01). The frequencies of COMT rs4680 “A” allele were higher in PD patients with pain than those without pain (46.1% vs. 31.1%, P < 0.01). Pain severity was significantly associated with disease duration (P = 0.02), and COMT rs6267 T allele (P < 0.01). We stratified PD by status of depression and the association between COMT rs6267 “GT” genotype and pain severity remained significant (P < 0.01). Furthermore, pain severity was significantly higher in participants having COMT rs4680 “GG” and “GA” genpotypes than those having “AA” genotype (P = 0.04). We concluded that depression and COMT rs4680 “GG” and “GA” genotypes and COMT rs6267 “GT” genotype contribute to pain in PD patients.
format	article
author	Chin-Hsien Lin K. Ray Chaudhuri Jun-Yu Fan Chia-I. Ko Alexandra Rizos Chia-Wen Chang Han-I. Lin Yih-Ru Wu
author_facet	Chin-Hsien Lin K. Ray Chaudhuri Jun-Yu Fan Chia-I. Ko Alexandra Rizos Chia-Wen Chang Han-I. Lin Yih-Ru Wu
author_sort	Chin-Hsien Lin
title	Depression and Catechol-O-methyltransferase (COMT) genetic variants are associated with pain in Parkinson’s disease
title_short	Depression and Catechol-O-methyltransferase (COMT) genetic variants are associated with pain in Parkinson’s disease
title_full	Depression and Catechol-O-methyltransferase (COMT) genetic variants are associated with pain in Parkinson’s disease
title_fullStr	Depression and Catechol-O-methyltransferase (COMT) genetic variants are associated with pain in Parkinson’s disease
title_full_unstemmed	Depression and Catechol-O-methyltransferase (COMT) genetic variants are associated with pain in Parkinson’s disease
title_sort	depression and catechol-o-methyltransferase (comt) genetic variants are associated with pain in parkinson’s disease
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/3247aecccc8a4ab2985b8fdc66899e51
work_keys_str_mv	AT chinhsienlin depressionandcatecholomethyltransferasecomtgeneticvariantsareassociatedwithpaininparkinsonsdisease AT kraychaudhuri depressionandcatecholomethyltransferasecomtgeneticvariantsareassociatedwithpaininparkinsonsdisease AT junyufan depressionandcatecholomethyltransferasecomtgeneticvariantsareassociatedwithpaininparkinsonsdisease AT chiaiko depressionandcatecholomethyltransferasecomtgeneticvariantsareassociatedwithpaininparkinsonsdisease AT alexandrarizos depressionandcatecholomethyltransferasecomtgeneticvariantsareassociatedwithpaininparkinsonsdisease AT chiawenchang depressionandcatecholomethyltransferasecomtgeneticvariantsareassociatedwithpaininparkinsonsdisease AT hanilin depressionandcatecholomethyltransferasecomtgeneticvariantsareassociatedwithpaininparkinsonsdisease AT yihruwu depressionandcatecholomethyltransferasecomtgeneticvariantsareassociatedwithpaininparkinsonsdisease
_version_	1718394268073066496

Depression and Catechol-O-methyltransferase (COMT) genetic variants are associated with pain in Parkinson’s disease

Ejemplares similares