High Rate of Infection by Only Oncogenic Human Papillomavirus in Amerindians

ABSTRACT Human papillomavirus (HPV), an etiological agent of cervical cancer (CC), has infected humans since ancient times. Amerindians are the furthest migrants out of Africa, and they reached the Americas more than 14,000 years ago. Some groups still remain isolated, and some migrate to towns, for...

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Autores principales:	Daniela Vargas-Robles, Magda Magris, Natalia Morales, Maurits N. C. de Koning, Iveth Rodríguez, Tahidid Nieves, Filipa Godoy-Vitorino, Gloria I. Sánchez, Luis David Alcaraz, Larry J. Forney, María-Eglée Pérez, Luis García-Briceño, Leen-Jan van Doorn, María Gloria Domínguez-Bello
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2018
Materias:	diversity human papillomavirus lifestyle oncogenic virus urbanization Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/32480cdcb60e4db886e761ec93dd3e17
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spelling	oai:doaj.org-article:32480cdcb60e4db886e761ec93dd3e172021-11-15T15:24:22ZHigh Rate of Infection by Only Oncogenic Human Papillomavirus in Amerindians10.1128/mSphere.00176-182379-5042https://doaj.org/article/32480cdcb60e4db886e761ec93dd3e172018-06-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mSphere.00176-18https://doaj.org/toc/2379-5042ABSTRACT Human papillomavirus (HPV), an etiological agent of cervical cancer (CC), has infected humans since ancient times. Amerindians are the furthest migrants out of Africa, and they reached the Americas more than 14,000 years ago. Some groups still remain isolated, and some migrate to towns, forming a gradient spanning urbanization. We hypothesized that, by virtue of their history, lifestyle, and isolation from the global society, remote Amerindian women have lower HPV diversity than do urban women (Amerindian or mestizo). Here we determined the diversity of the 25 most relevant cervical HPV types in 82 Amerindians spanning urbanization (low, medium, and high, consistent with the exposure to urban lifestyles of the town of Puerto Ayacucho in the Venezuelan Amazonas State), and in 29 urban mestizos from the town. Cervical, anal, oral, and introitus samples were taken, and HPVs were typed using reverse DNA hybridization. A total of 23 HPV types were detected, including 11 oncogenic or high-risk types, most associated with CC. Cervical HPV prevalence was 75%, with no differences by group, but Amerindians from low and medium urbanization level had significantly lower HPV diversity than mestizos did. In Amerindians, but not in mestizos, infections by only high-risk HPVs were higher than coinfections or by exclusively low-risk HPVs. Cervical abnormalities only were observed in Amerindians (9/82), consistent with their high HPV infection. The lower cervical HPV diversity in more isolated Amerindians is consistent with their lower exposure to the global pool, and transculturation to urban lifestyles could have implications on HPV ecology, infection, and virulence. IMPORTANCE The role of HPV type distribution on the disparity of cervical cancer (CC) incidence between human populations remains unknown. The incidence of CC in the Amazonas State of Venezuela is higher than the national average. In this study, we determined the diversity of known HPV types (the viral agent of CC) in Amerindian and mestizo women living in the Venezuelan Amazonas State. Understanding the ecological diversity of HPV in populations undergoing lifestyle transformations has important implication on public health measures for CC prevention.Daniela Vargas-RoblesMagda MagrisNatalia MoralesMaurits N. C. de KoningIveth RodríguezTahidid NievesFilipa Godoy-VitorinoGloria I. SánchezLuis David AlcarazLarry J. ForneyMaría-Eglée PérezLuis García-BriceñoLeen-Jan van DoornMaría Gloria Domínguez-BelloAmerican Society for Microbiologyarticlediversityhuman papillomaviruslifestyleoncogenic virusurbanizationMicrobiologyQR1-502ENmSphere, Vol 3, Iss 3 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	diversity human papillomavirus lifestyle oncogenic virus urbanization Microbiology QR1-502
spellingShingle	diversity human papillomavirus lifestyle oncogenic virus urbanization Microbiology QR1-502 Daniela Vargas-Robles Magda Magris Natalia Morales Maurits N. C. de Koning Iveth Rodríguez Tahidid Nieves Filipa Godoy-Vitorino Gloria I. Sánchez Luis David Alcaraz Larry J. Forney María-Eglée Pérez Luis García-Briceño Leen-Jan van Doorn María Gloria Domínguez-Bello High Rate of Infection by Only Oncogenic Human Papillomavirus in Amerindians
description	ABSTRACT Human papillomavirus (HPV), an etiological agent of cervical cancer (CC), has infected humans since ancient times. Amerindians are the furthest migrants out of Africa, and they reached the Americas more than 14,000 years ago. Some groups still remain isolated, and some migrate to towns, forming a gradient spanning urbanization. We hypothesized that, by virtue of their history, lifestyle, and isolation from the global society, remote Amerindian women have lower HPV diversity than do urban women (Amerindian or mestizo). Here we determined the diversity of the 25 most relevant cervical HPV types in 82 Amerindians spanning urbanization (low, medium, and high, consistent with the exposure to urban lifestyles of the town of Puerto Ayacucho in the Venezuelan Amazonas State), and in 29 urban mestizos from the town. Cervical, anal, oral, and introitus samples were taken, and HPVs were typed using reverse DNA hybridization. A total of 23 HPV types were detected, including 11 oncogenic or high-risk types, most associated with CC. Cervical HPV prevalence was 75%, with no differences by group, but Amerindians from low and medium urbanization level had significantly lower HPV diversity than mestizos did. In Amerindians, but not in mestizos, infections by only high-risk HPVs were higher than coinfections or by exclusively low-risk HPVs. Cervical abnormalities only were observed in Amerindians (9/82), consistent with their high HPV infection. The lower cervical HPV diversity in more isolated Amerindians is consistent with their lower exposure to the global pool, and transculturation to urban lifestyles could have implications on HPV ecology, infection, and virulence. IMPORTANCE The role of HPV type distribution on the disparity of cervical cancer (CC) incidence between human populations remains unknown. The incidence of CC in the Amazonas State of Venezuela is higher than the national average. In this study, we determined the diversity of known HPV types (the viral agent of CC) in Amerindian and mestizo women living in the Venezuelan Amazonas State. Understanding the ecological diversity of HPV in populations undergoing lifestyle transformations has important implication on public health measures for CC prevention.
format	article
author	Daniela Vargas-Robles Magda Magris Natalia Morales Maurits N. C. de Koning Iveth Rodríguez Tahidid Nieves Filipa Godoy-Vitorino Gloria I. Sánchez Luis David Alcaraz Larry J. Forney María-Eglée Pérez Luis García-Briceño Leen-Jan van Doorn María Gloria Domínguez-Bello
author_facet	Daniela Vargas-Robles Magda Magris Natalia Morales Maurits N. C. de Koning Iveth Rodríguez Tahidid Nieves Filipa Godoy-Vitorino Gloria I. Sánchez Luis David Alcaraz Larry J. Forney María-Eglée Pérez Luis García-Briceño Leen-Jan van Doorn María Gloria Domínguez-Bello
author_sort	Daniela Vargas-Robles
title	High Rate of Infection by Only Oncogenic Human Papillomavirus in Amerindians
title_short	High Rate of Infection by Only Oncogenic Human Papillomavirus in Amerindians
title_full	High Rate of Infection by Only Oncogenic Human Papillomavirus in Amerindians
title_fullStr	High Rate of Infection by Only Oncogenic Human Papillomavirus in Amerindians
title_full_unstemmed	High Rate of Infection by Only Oncogenic Human Papillomavirus in Amerindians
title_sort	high rate of infection by only oncogenic human papillomavirus in amerindians
publisher	American Society for Microbiology
publishDate	2018
url	https://doaj.org/article/32480cdcb60e4db886e761ec93dd3e17
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High Rate of Infection by Only Oncogenic Human Papillomavirus in Amerindians

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