Association of asymptomatic target organ damage with secreted frizzled related protein 5 in the elderly: the Northern Shanghai Study

Jiadela Teliewubai,1 Bin Bai,1 Yiwu Zhou,1 Yuyan Lu,1 Shikai Yu,1 Chen Chi,1 Jue Li,2 Jacques Blacher,3 Yawei Xu,1 Yi Zhang1 1Department of Cardiology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, China; 2The Research Institute of Clinical Epidemiology...

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Autores principales:	Teliewubai J, Bai B, Zhou Y, Lu Y, Yu S, Chi C, Li J, Blacher J, Xu Y, Zhang Y
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	Secreted frizzled related protein 5 Cardiovascular disease asymptomatic target organ damage arterial stiffness Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/3248c8d2c6db47ffa3562141aee01fa3
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spelling	oai:doaj.org-article:3248c8d2c6db47ffa3562141aee01fa32021-12-02T01:10:17ZAssociation of asymptomatic target organ damage with secreted frizzled related protein 5 in the elderly: the Northern Shanghai Study1178-1998https://doaj.org/article/3248c8d2c6db47ffa3562141aee01fa32018-03-01T00:00:00Zhttps://www.dovepress.com/association-of-asymptomatic-target-organ-damage-with-secreted-frizzled-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Jiadela Teliewubai,1 Bin Bai,1 Yiwu Zhou,1 Yuyan Lu,1 Shikai Yu,1 Chen Chi,1 Jue Li,2 Jacques Blacher,3 Yawei Xu,1 Yi Zhang1 1Department of Cardiology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, China; 2The Research Institute of Clinical Epidemiology, Tongji University School of Medicine, Shanghai, China; 3AP-HP, Diagnosis and Therapeutic Center, Hôtel-Dieu, Paris Descartes University, Paris, France Objective: Secreted frizzled related protein 5 (SFRP5) is a novel anti-inflammatory adipokine that is implicated in metabolic and cardiovascular disease (CVD). However, little is known about the relevance of SFRP5 with asymptomatic hypertensive target organ damages (TODs). We aimed to investigate the association between SFRP5 and TOD in a large population.Clinical trial registration: NCT02368938.Methods: A total of 1,745 community-dwelling elderly subjects aged over 65 years from northern Shanghai were recruited in the study. Plasma SFRP5 level was measured by an enzyme-linked immunosorbent assay. Asymptomatic TODs, including left ventricular mass index, peak transmitral pulsed Doppler velocity/early diastolic tissue Doppler velocity, carotid intima–media thickness (CIMT), pulse wave velocity (PWV), estimated glomerular filtration rate, and urinary albumin–creatinine ratio were evaluated.Results: Plasma SFRP5 level was negatively associated with body mass index, waist/hip ratio, and fasting blood glucose (all P<0.001). Men, compared with women, had lower plasma SFRP5 level (4.19 vs 5.13 ng/mL, P<0.001). Additionally, plasma SFRP5 level was lower in diabetics than in those without diabetes (4.30 vs 4.81 ng/mL, P<0.05). Furthermore, an inverse association was observed between SFRP5 and PWV and CIMT (both P<0.05). Lastly, the multivariate logistic regression analysis showed lower SFRP5 level was significantly associated with increased arterial stiffness in the elderly (odds ratio 0.83, 95% confidence interval 0.71 to 0.99 per 1 standard deviation increase, P<0.05).Conclusion: Plasma SFRP5 level was inversely correlated with conventional cardiovascular risk factors, and low plasma SFRP5 was also significantly associated with arterial stiffening in the elderly Chinese population. Keywords: secreted frizzled related protein 5, cardiovascular disease, asymptomatic target organ damage, arterial stiffnessTeliewubai JBai BZhou YLu YYu SChi CLi JBlacher JXu YZhang YDove Medical PressarticleSecreted frizzled related protein 5Cardiovascular diseaseasymptomatic target organ damagearterial stiffnessGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 13, Pp 389-395 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Secreted frizzled related protein 5 Cardiovascular disease asymptomatic target organ damage arterial stiffness Geriatrics RC952-954.6
spellingShingle	Secreted frizzled related protein 5 Cardiovascular disease asymptomatic target organ damage arterial stiffness Geriatrics RC952-954.6 Teliewubai J Bai B Zhou Y Lu Y Yu S Chi C Li J Blacher J Xu Y Zhang Y Association of asymptomatic target organ damage with secreted frizzled related protein 5 in the elderly: the Northern Shanghai Study
description	Jiadela Teliewubai,1 Bin Bai,1 Yiwu Zhou,1 Yuyan Lu,1 Shikai Yu,1 Chen Chi,1 Jue Li,2 Jacques Blacher,3 Yawei Xu,1 Yi Zhang1 1Department of Cardiology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, China; 2The Research Institute of Clinical Epidemiology, Tongji University School of Medicine, Shanghai, China; 3AP-HP, Diagnosis and Therapeutic Center, Hôtel-Dieu, Paris Descartes University, Paris, France Objective: Secreted frizzled related protein 5 (SFRP5) is a novel anti-inflammatory adipokine that is implicated in metabolic and cardiovascular disease (CVD). However, little is known about the relevance of SFRP5 with asymptomatic hypertensive target organ damages (TODs). We aimed to investigate the association between SFRP5 and TOD in a large population.Clinical trial registration: NCT02368938.Methods: A total of 1,745 community-dwelling elderly subjects aged over 65 years from northern Shanghai were recruited in the study. Plasma SFRP5 level was measured by an enzyme-linked immunosorbent assay. Asymptomatic TODs, including left ventricular mass index, peak transmitral pulsed Doppler velocity/early diastolic tissue Doppler velocity, carotid intima–media thickness (CIMT), pulse wave velocity (PWV), estimated glomerular filtration rate, and urinary albumin–creatinine ratio were evaluated.Results: Plasma SFRP5 level was negatively associated with body mass index, waist/hip ratio, and fasting blood glucose (all P<0.001). Men, compared with women, had lower plasma SFRP5 level (4.19 vs 5.13 ng/mL, P<0.001). Additionally, plasma SFRP5 level was lower in diabetics than in those without diabetes (4.30 vs 4.81 ng/mL, P<0.05). Furthermore, an inverse association was observed between SFRP5 and PWV and CIMT (both P<0.05). Lastly, the multivariate logistic regression analysis showed lower SFRP5 level was significantly associated with increased arterial stiffness in the elderly (odds ratio 0.83, 95% confidence interval 0.71 to 0.99 per 1 standard deviation increase, P<0.05).Conclusion: Plasma SFRP5 level was inversely correlated with conventional cardiovascular risk factors, and low plasma SFRP5 was also significantly associated with arterial stiffening in the elderly Chinese population. Keywords: secreted frizzled related protein 5, cardiovascular disease, asymptomatic target organ damage, arterial stiffness
format	article
author	Teliewubai J Bai B Zhou Y Lu Y Yu S Chi C Li J Blacher J Xu Y Zhang Y
author_facet	Teliewubai J Bai B Zhou Y Lu Y Yu S Chi C Li J Blacher J Xu Y Zhang Y
author_sort	Teliewubai J
title	Association of asymptomatic target organ damage with secreted frizzled related protein 5 in the elderly: the Northern Shanghai Study
title_short	Association of asymptomatic target organ damage with secreted frizzled related protein 5 in the elderly: the Northern Shanghai Study
title_full	Association of asymptomatic target organ damage with secreted frizzled related protein 5 in the elderly: the Northern Shanghai Study
title_fullStr	Association of asymptomatic target organ damage with secreted frizzled related protein 5 in the elderly: the Northern Shanghai Study
title_full_unstemmed	Association of asymptomatic target organ damage with secreted frizzled related protein 5 in the elderly: the Northern Shanghai Study
title_sort	association of asymptomatic target organ damage with secreted frizzled related protein 5 in the elderly: the northern shanghai study
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/3248c8d2c6db47ffa3562141aee01fa3
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Association of asymptomatic target organ damage with secreted frizzled related protein 5 in the elderly: the Northern Shanghai Study

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