Sexually dimorphic patterns in maternal circulating microRNAs in pregnancies complicated by fetal growth restriction

Highlights Detection and treatment of pregnancies at high risk of fetal growth restriction (FGR) and stillbirth remains a major obstetric challenge; circulating maternal serum microRNAs (miRNAs) offer potential as novel biomarkers. Unbiased analysis of serum miRNAs in women in late pregnancy identif...

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Autores principales:	Bernadette C. Baker, Sylvia Lui, Isabel Lorne, Alexander E. P. Heazell, Karen Forbes, Rebecca L. Jones
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	miRNA Placenta Pregnancy Serum Biomarker Placental dysfunction Medicine R Physiology QP1-981
Acceso en línea:	https://doaj.org/article/324f8ca743a641bbb7a14311b4b8d9c3
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spelling	oai:doaj.org-article:324f8ca743a641bbb7a14311b4b8d9c32021-11-21T12:03:10ZSexually dimorphic patterns in maternal circulating microRNAs in pregnancies complicated by fetal growth restriction10.1186/s13293-021-00405-z2042-6410https://doaj.org/article/324f8ca743a641bbb7a14311b4b8d9c32021-11-01T00:00:00Zhttps://doi.org/10.1186/s13293-021-00405-zhttps://doaj.org/toc/2042-6410Highlights Detection and treatment of pregnancies at high risk of fetal growth restriction (FGR) and stillbirth remains a major obstetric challenge; circulating maternal serum microRNAs (miRNAs) offer potential as novel biomarkers. Unbiased analysis of serum miRNAs in women in late pregnancy identified a specific profile of circulating miRNAs in women with a growth-restricted infant. Some altered miRNAs (miR-28-5p, miR-301a-3p) showed sexually dimorphic expression in FGR pregnancies and others a fetal-sex dependent association to a hormonal marker of placental dysfunction (miR-454-3p, miR-29c-3p). miR-301a-3p and miR-28-5p could potentially be used to predict FGR specifically in pregnancies with a male or female baby, respectively, however larger cohort studies are required. Further investigations of these miRNAs and their relationship to placental dysfunction will lead to a better understanding of the pathophysiology of FGR and why there is differing susceptibility of male and female fetuses to FGR and stillbirth.Bernadette C. BakerSylvia LuiIsabel LorneAlexander E. P. HeazellKaren ForbesRebecca L. JonesBMCarticlemiRNAPlacentaPregnancySerumBiomarkerPlacental dysfunctionMedicineRPhysiologyQP1-981ENBiology of Sex Differences, Vol 12, Iss 1, Pp 1-20 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	miRNA Placenta Pregnancy Serum Biomarker Placental dysfunction Medicine R Physiology QP1-981
spellingShingle	miRNA Placenta Pregnancy Serum Biomarker Placental dysfunction Medicine R Physiology QP1-981 Bernadette C. Baker Sylvia Lui Isabel Lorne Alexander E. P. Heazell Karen Forbes Rebecca L. Jones Sexually dimorphic patterns in maternal circulating microRNAs in pregnancies complicated by fetal growth restriction
description	Highlights Detection and treatment of pregnancies at high risk of fetal growth restriction (FGR) and stillbirth remains a major obstetric challenge; circulating maternal serum microRNAs (miRNAs) offer potential as novel biomarkers. Unbiased analysis of serum miRNAs in women in late pregnancy identified a specific profile of circulating miRNAs in women with a growth-restricted infant. Some altered miRNAs (miR-28-5p, miR-301a-3p) showed sexually dimorphic expression in FGR pregnancies and others a fetal-sex dependent association to a hormonal marker of placental dysfunction (miR-454-3p, miR-29c-3p). miR-301a-3p and miR-28-5p could potentially be used to predict FGR specifically in pregnancies with a male or female baby, respectively, however larger cohort studies are required. Further investigations of these miRNAs and their relationship to placental dysfunction will lead to a better understanding of the pathophysiology of FGR and why there is differing susceptibility of male and female fetuses to FGR and stillbirth.
format	article
author	Bernadette C. Baker Sylvia Lui Isabel Lorne Alexander E. P. Heazell Karen Forbes Rebecca L. Jones
author_facet	Bernadette C. Baker Sylvia Lui Isabel Lorne Alexander E. P. Heazell Karen Forbes Rebecca L. Jones
author_sort	Bernadette C. Baker
title	Sexually dimorphic patterns in maternal circulating microRNAs in pregnancies complicated by fetal growth restriction
title_short	Sexually dimorphic patterns in maternal circulating microRNAs in pregnancies complicated by fetal growth restriction
title_full	Sexually dimorphic patterns in maternal circulating microRNAs in pregnancies complicated by fetal growth restriction
title_fullStr	Sexually dimorphic patterns in maternal circulating microRNAs in pregnancies complicated by fetal growth restriction
title_full_unstemmed	Sexually dimorphic patterns in maternal circulating microRNAs in pregnancies complicated by fetal growth restriction
title_sort	sexually dimorphic patterns in maternal circulating micrornas in pregnancies complicated by fetal growth restriction
publisher	BMC
publishDate	2021
url	https://doaj.org/article/324f8ca743a641bbb7a14311b4b8d9c3
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Sexually dimorphic patterns in maternal circulating microRNAs in pregnancies complicated by fetal growth restriction

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