Sexually dimorphic patterns in maternal circulating microRNAs in pregnancies complicated by fetal growth restriction
Highlights Detection and treatment of pregnancies at high risk of fetal growth restriction (FGR) and stillbirth remains a major obstetric challenge; circulating maternal serum microRNAs (miRNAs) offer potential as novel biomarkers. Unbiased analysis of serum miRNAs in women in late pregnancy identif...
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2021
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oai:doaj.org-article:324f8ca743a641bbb7a14311b4b8d9c32021-11-21T12:03:10ZSexually dimorphic patterns in maternal circulating microRNAs in pregnancies complicated by fetal growth restriction10.1186/s13293-021-00405-z2042-6410https://doaj.org/article/324f8ca743a641bbb7a14311b4b8d9c32021-11-01T00:00:00Zhttps://doi.org/10.1186/s13293-021-00405-zhttps://doaj.org/toc/2042-6410Highlights Detection and treatment of pregnancies at high risk of fetal growth restriction (FGR) and stillbirth remains a major obstetric challenge; circulating maternal serum microRNAs (miRNAs) offer potential as novel biomarkers. Unbiased analysis of serum miRNAs in women in late pregnancy identified a specific profile of circulating miRNAs in women with a growth-restricted infant. Some altered miRNAs (miR-28-5p, miR-301a-3p) showed sexually dimorphic expression in FGR pregnancies and others a fetal-sex dependent association to a hormonal marker of placental dysfunction (miR-454-3p, miR-29c-3p). miR-301a-3p and miR-28-5p could potentially be used to predict FGR specifically in pregnancies with a male or female baby, respectively, however larger cohort studies are required. Further investigations of these miRNAs and their relationship to placental dysfunction will lead to a better understanding of the pathophysiology of FGR and why there is differing susceptibility of male and female fetuses to FGR and stillbirth.Bernadette C. BakerSylvia LuiIsabel LorneAlexander E. P. HeazellKaren ForbesRebecca L. JonesBMCarticlemiRNAPlacentaPregnancySerumBiomarkerPlacental dysfunctionMedicineRPhysiologyQP1-981ENBiology of Sex Differences, Vol 12, Iss 1, Pp 1-20 (2021) |
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miRNA Placenta Pregnancy Serum Biomarker Placental dysfunction Medicine R Physiology QP1-981 |
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miRNA Placenta Pregnancy Serum Biomarker Placental dysfunction Medicine R Physiology QP1-981 Bernadette C. Baker Sylvia Lui Isabel Lorne Alexander E. P. Heazell Karen Forbes Rebecca L. Jones Sexually dimorphic patterns in maternal circulating microRNAs in pregnancies complicated by fetal growth restriction |
| description |
Highlights Detection and treatment of pregnancies at high risk of fetal growth restriction (FGR) and stillbirth remains a major obstetric challenge; circulating maternal serum microRNAs (miRNAs) offer potential as novel biomarkers. Unbiased analysis of serum miRNAs in women in late pregnancy identified a specific profile of circulating miRNAs in women with a growth-restricted infant. Some altered miRNAs (miR-28-5p, miR-301a-3p) showed sexually dimorphic expression in FGR pregnancies and others a fetal-sex dependent association to a hormonal marker of placental dysfunction (miR-454-3p, miR-29c-3p). miR-301a-3p and miR-28-5p could potentially be used to predict FGR specifically in pregnancies with a male or female baby, respectively, however larger cohort studies are required. Further investigations of these miRNAs and their relationship to placental dysfunction will lead to a better understanding of the pathophysiology of FGR and why there is differing susceptibility of male and female fetuses to FGR and stillbirth. |
| format |
article |
| author |
Bernadette C. Baker Sylvia Lui Isabel Lorne Alexander E. P. Heazell Karen Forbes Rebecca L. Jones |
| author_facet |
Bernadette C. Baker Sylvia Lui Isabel Lorne Alexander E. P. Heazell Karen Forbes Rebecca L. Jones |
| author_sort |
Bernadette C. Baker |
| title |
Sexually dimorphic patterns in maternal circulating microRNAs in pregnancies complicated by fetal growth restriction |
| title_short |
Sexually dimorphic patterns in maternal circulating microRNAs in pregnancies complicated by fetal growth restriction |
| title_full |
Sexually dimorphic patterns in maternal circulating microRNAs in pregnancies complicated by fetal growth restriction |
| title_fullStr |
Sexually dimorphic patterns in maternal circulating microRNAs in pregnancies complicated by fetal growth restriction |
| title_full_unstemmed |
Sexually dimorphic patterns in maternal circulating microRNAs in pregnancies complicated by fetal growth restriction |
| title_sort |
sexually dimorphic patterns in maternal circulating micrornas in pregnancies complicated by fetal growth restriction |
| publisher |
BMC |
| publishDate |
2021 |
| url |
https://doaj.org/article/324f8ca743a641bbb7a14311b4b8d9c3 |
| work_keys_str_mv |
AT bernadettecbaker sexuallydimorphicpatternsinmaternalcirculatingmicrornasinpregnanciescomplicatedbyfetalgrowthrestriction AT sylvialui sexuallydimorphicpatternsinmaternalcirculatingmicrornasinpregnanciescomplicatedbyfetalgrowthrestriction AT isabellorne sexuallydimorphicpatternsinmaternalcirculatingmicrornasinpregnanciescomplicatedbyfetalgrowthrestriction AT alexanderepheazell sexuallydimorphicpatternsinmaternalcirculatingmicrornasinpregnanciescomplicatedbyfetalgrowthrestriction AT karenforbes sexuallydimorphicpatternsinmaternalcirculatingmicrornasinpregnanciescomplicatedbyfetalgrowthrestriction AT rebeccaljones sexuallydimorphicpatternsinmaternalcirculatingmicrornasinpregnanciescomplicatedbyfetalgrowthrestriction |
| _version_ |
1718419294851694592 |