Redesigning an antibody H3 loop by virtual screening of a small library of human germline-derived sequences
Abstract The design of superior biologic therapeutics, including antibodies and engineered proteins, involves optimizing their specific ability to bind to disease-related molecular targets. Previously, we developed and applied the Assisted Design of Antibody and Protein Therapeutics (ADAPT) platform...
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Autores principales: | Christopher R. Corbeil, Mahder Seifu Manenda, Traian Sulea, Jason Baardsnes, Marie-Ève Picard, Hervé Hogues, Francis Gaudreault, Christophe Deprez, Rong Shi, Enrico O. Purisima |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2021
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Materias: | |
Acceso en línea: | https://doaj.org/article/32593c24308a497ea7ce2a68ef263f47 |
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