CTC1-STN1 terminates telomerase while STN1-TEN1 enables C-strand synthesis during telomere replication in colon cancer cells

CTC1-STN1 terminates telomerase while STN1-TEN1 enables C-strand synthesis during telomere replication in colon cancer cells

The human CST complex (CTC1-STN1-TEN1) is essential for telomere homeostasis. Here the authors dissect the roles of individual CST subunits in telomere length maintenance through regulation of telomerase-mediated G-strand synthesis and DNA polymerase-mediated C-strand synthesis in colon cancer cells...

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Autores principales: Xuyang Feng, Shih-Jui Hsu, Anukana Bhattacharjee, Yongyao Wang, Jiajie Diao, Carolyn M. Price
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/325da1580ad74e159f33e569163446ad
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spelling oai:doaj.org-article:325da1580ad74e159f33e569163446ad2021-12-02T16:49:55ZCTC1-STN1 terminates telomerase while STN1-TEN1 enables C-strand synthesis during telomere replication in colon cancer cells10.1038/s41467-018-05154-z2041-1723https://doaj.org/article/325da1580ad74e159f33e569163446ad2018-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05154-zhttps://doaj.org/toc/2041-1723The human CST complex (CTC1-STN1-TEN1) is essential for telomere homeostasis. Here the authors dissect the roles of individual CST subunits in telomere length maintenance through regulation of telomerase-mediated G-strand synthesis and DNA polymerase-mediated C-strand synthesis in colon cancer cells.Xuyang FengShih-Jui HsuAnukana BhattacharjeeYongyao WangJiajie DiaoCarolyn M. PriceNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Xuyang Feng
Shih-Jui Hsu
Anukana Bhattacharjee
Yongyao Wang
Jiajie Diao
Carolyn M. Price
CTC1-STN1 terminates telomerase while STN1-TEN1 enables C-strand synthesis during telomere replication in colon cancer cells
description The human CST complex (CTC1-STN1-TEN1) is essential for telomere homeostasis. Here the authors dissect the roles of individual CST subunits in telomere length maintenance through regulation of telomerase-mediated G-strand synthesis and DNA polymerase-mediated C-strand synthesis in colon cancer cells.
format article
author Xuyang Feng
Shih-Jui Hsu
Anukana Bhattacharjee
Yongyao Wang
Jiajie Diao
Carolyn M. Price
author_facet Xuyang Feng
Shih-Jui Hsu
Anukana Bhattacharjee
Yongyao Wang
Jiajie Diao
Carolyn M. Price
author_sort Xuyang Feng
title CTC1-STN1 terminates telomerase while STN1-TEN1 enables C-strand synthesis during telomere replication in colon cancer cells
title_short CTC1-STN1 terminates telomerase while STN1-TEN1 enables C-strand synthesis during telomere replication in colon cancer cells
title_full CTC1-STN1 terminates telomerase while STN1-TEN1 enables C-strand synthesis during telomere replication in colon cancer cells
title_fullStr CTC1-STN1 terminates telomerase while STN1-TEN1 enables C-strand synthesis during telomere replication in colon cancer cells
title_full_unstemmed CTC1-STN1 terminates telomerase while STN1-TEN1 enables C-strand synthesis during telomere replication in colon cancer cells
title_sort ctc1-stn1 terminates telomerase while stn1-ten1 enables c-strand synthesis during telomere replication in colon cancer cells
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/325da1580ad74e159f33e569163446ad
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AT shihjuihsu ctc1stn1terminatestelomerasewhilestn1ten1enablescstrandsynthesisduringtelomerereplicationincoloncancercells
AT anukanabhattacharjee ctc1stn1terminatestelomerasewhilestn1ten1enablescstrandsynthesisduringtelomerereplicationincoloncancercells
AT yongyaowang ctc1stn1terminatestelomerasewhilestn1ten1enablescstrandsynthesisduringtelomerereplicationincoloncancercells
AT jiajiediao ctc1stn1terminatestelomerasewhilestn1ten1enablescstrandsynthesisduringtelomerereplicationincoloncancercells
AT carolynmprice ctc1stn1terminatestelomerasewhilestn1ten1enablescstrandsynthesisduringtelomerereplicationincoloncancercells
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