HIV-1 vaccination by needle-free oral injection induces strong mucosal immunity and protects against SHIV challenge

HIV-1 vaccination by needle-free oral injection induces strong mucosal immunity and protects against SHIV challenge

Oral vaccination is a potential option to elicit systemic and mucosal immunity against HIV. Here, Jones et al. show that oral vaccination with a modified needle-free injector induces protective immunity against SHIV in non-human primates and is superior to topical application of vaccines to oral tis...

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Autores principales: Andrew T. Jones, Xiaoying Shen, Korey L. Walter, Celia C. LaBranche, Linda S. Wyatt, Georgia D. Tomaras, David C. Montefiori, Bernard Moss, Dan H. Barouch, John D. Clements, Pamela A. Kozlowski, Raghavan Varadarajan, Rama Rao Amara
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Science
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Acceso en línea:https://doaj.org/article/3261e8231c1a42bea898a73162efaeea
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Sumario:Oral vaccination is a potential option to elicit systemic and mucosal immunity against HIV. Here, Jones et al. show that oral vaccination with a modified needle-free injector induces protective immunity against SHIV in non-human primates and is superior to topical application of vaccines to oral tissues.

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