HIV-1 vaccination by needle-free oral injection induces strong mucosal immunity and protects against SHIV challenge

Oral vaccination is a potential option to elicit systemic and mucosal immunity against HIV. Here, Jones et al. show that oral vaccination with a modified needle-free injector induces protective immunity against SHIV in non-human primates and is superior to topical application of vaccines to oral tis...

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Autores principales:	Andrew T. Jones, Xiaoying Shen, Korey L. Walter, Celia C. LaBranche, Linda S. Wyatt, Georgia D. Tomaras, David C. Montefiori, Bernard Moss, Dan H. Barouch, John D. Clements, Pamela A. Kozlowski, Raghavan Varadarajan, Rama Rao Amara
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3261e8231c1a42bea898a73162efaeea
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spelling	oai:doaj.org-article:3261e8231c1a42bea898a73162efaeea2021-12-02T15:35:28ZHIV-1 vaccination by needle-free oral injection induces strong mucosal immunity and protects against SHIV challenge10.1038/s41467-019-08739-42041-1723https://doaj.org/article/3261e8231c1a42bea898a73162efaeea2019-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08739-4https://doaj.org/toc/2041-1723Oral vaccination is a potential option to elicit systemic and mucosal immunity against HIV. Here, Jones et al. show that oral vaccination with a modified needle-free injector induces protective immunity against SHIV in non-human primates and is superior to topical application of vaccines to oral tissues.Andrew T. JonesXiaoying ShenKorey L. WalterCelia C. LaBrancheLinda S. WyattGeorgia D. TomarasDavid C. MontefioriBernard MossDan H. BarouchJohn D. ClementsPamela A. KozlowskiRaghavan VaradarajanRama Rao AmaraNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Andrew T. Jones Xiaoying Shen Korey L. Walter Celia C. LaBranche Linda S. Wyatt Georgia D. Tomaras David C. Montefiori Bernard Moss Dan H. Barouch John D. Clements Pamela A. Kozlowski Raghavan Varadarajan Rama Rao Amara HIV-1 vaccination by needle-free oral injection induces strong mucosal immunity and protects against SHIV challenge
description	Oral vaccination is a potential option to elicit systemic and mucosal immunity against HIV. Here, Jones et al. show that oral vaccination with a modified needle-free injector induces protective immunity against SHIV in non-human primates and is superior to topical application of vaccines to oral tissues.
format	article
author	Andrew T. Jones Xiaoying Shen Korey L. Walter Celia C. LaBranche Linda S. Wyatt Georgia D. Tomaras David C. Montefiori Bernard Moss Dan H. Barouch John D. Clements Pamela A. Kozlowski Raghavan Varadarajan Rama Rao Amara
author_facet	Andrew T. Jones Xiaoying Shen Korey L. Walter Celia C. LaBranche Linda S. Wyatt Georgia D. Tomaras David C. Montefiori Bernard Moss Dan H. Barouch John D. Clements Pamela A. Kozlowski Raghavan Varadarajan Rama Rao Amara
author_sort	Andrew T. Jones
title	HIV-1 vaccination by needle-free oral injection induces strong mucosal immunity and protects against SHIV challenge
title_short	HIV-1 vaccination by needle-free oral injection induces strong mucosal immunity and protects against SHIV challenge
title_full	HIV-1 vaccination by needle-free oral injection induces strong mucosal immunity and protects against SHIV challenge
title_fullStr	HIV-1 vaccination by needle-free oral injection induces strong mucosal immunity and protects against SHIV challenge
title_full_unstemmed	HIV-1 vaccination by needle-free oral injection induces strong mucosal immunity and protects against SHIV challenge
title_sort	hiv-1 vaccination by needle-free oral injection induces strong mucosal immunity and protects against shiv challenge
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/3261e8231c1a42bea898a73162efaeea
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HIV-1 vaccination by needle-free oral injection induces strong mucosal immunity and protects against SHIV challenge

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