Screening for Depression in Mobile Devices Using Patient Health Questionnaire-9 (PHQ-9) Data: A Diagnostic Meta-Analysis via Machine Learning Methods
Sunhae Kim, Kounseok Lee Department of Psychiatry, Hanyang University Medical Center, Seoul, KoreaCorrespondence: Kounseok Lee Tel +82 2 2290 8423Fax +82 2 2298 2055Email dual@hanyang.ac.krPurpose: Depression is a symptom commonly encountered in primary care; however, it is often not detected by doc...
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oai:doaj.org-article:32620ae534c2428a96db7434a11043562021-11-21T19:08:51ZScreening for Depression in Mobile Devices Using Patient Health Questionnaire-9 (PHQ-9) Data: A Diagnostic Meta-Analysis via Machine Learning Methods1178-2021https://doaj.org/article/32620ae534c2428a96db7434a11043562021-11-01T00:00:00Zhttps://www.dovepress.com/screening-for-depression-in-mobile-devices-using-patient-health-questi-peer-reviewed-fulltext-article-NDThttps://doaj.org/toc/1178-2021Sunhae Kim, Kounseok Lee Department of Psychiatry, Hanyang University Medical Center, Seoul, KoreaCorrespondence: Kounseok Lee Tel +82 2 2290 8423Fax +82 2 2298 2055Email dual@hanyang.ac.krPurpose: Depression is a symptom commonly encountered in primary care; however, it is often not detected by doctors. Recently, disease diagnosis and treatment approaches have been attempted using smart devices. In this study, instrumental effectiveness was confirmed with the diagnostic meta-analysis of studies that demonstrated the diagnostic effectiveness of PHQ-9 for depression using mobile devices.Patients and Methods: We found all published and unpublished studies through EMBASE, MEDLINE, MEDLINE In-Process, and PsychINFO up to March 26, 2021. We performed a meta-analysis by including 1099 subjects in four studies. We performed a diagnostic meta-analysis according to the PHQ-9 cut-off score and machine learning algorithm techniques. Quality assessment was conducted using the QUADAS-2 tool. Data on the sensitivity and specificity of the studies included in the meta-analysis were extracted in a standardized format. Bivariate and summary receiver operating characteristic (SROC) curve were constructed using the metandi, midas, metabias, and metareg functions of the Stata algorithm meta-analysis words.Results: Using four studies out of the 5476 papers searched, a diagnostic meta-analysis of the PHQ-9 scores of 1099 people diagnosed with depression was performed. The pooled sensitivity and specificity were 0.797 (95% CI = 0.642– 0.895) and 0.85 (95% CI = 0.780– 0.900), respectively. The diagnostic odds ratio was 22.16 (95% CI = 7.273– 67.499). Overall, a good balance was maintained, and no heterogeneity or publication bias was presented.Conclusion: Through various machine learning algorithm techniques, it was possible to confirm that PHQ-9 depression screening in mobiles is an effective diagnostic tool when integrated into a diagnostic meta-analysis.Keywords: diagnostic meta-analysis, depression, Patient Health Questionnaire-9, machine learning, mobile, diagnosisKim SLee KDove Medical Pressarticlediagnostic meta-analysisdepressionpatient health questionnaire-9machine learningmobilediagnosisNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 17, Pp 3415-3430 (2021) |
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diagnostic meta-analysis depression patient health questionnaire-9 machine learning mobile diagnosis Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 |
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diagnostic meta-analysis depression patient health questionnaire-9 machine learning mobile diagnosis Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Kim S Lee K Screening for Depression in Mobile Devices Using Patient Health Questionnaire-9 (PHQ-9) Data: A Diagnostic Meta-Analysis via Machine Learning Methods |
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Sunhae Kim, Kounseok Lee Department of Psychiatry, Hanyang University Medical Center, Seoul, KoreaCorrespondence: Kounseok Lee Tel +82 2 2290 8423Fax +82 2 2298 2055Email dual@hanyang.ac.krPurpose: Depression is a symptom commonly encountered in primary care; however, it is often not detected by doctors. Recently, disease diagnosis and treatment approaches have been attempted using smart devices. In this study, instrumental effectiveness was confirmed with the diagnostic meta-analysis of studies that demonstrated the diagnostic effectiveness of PHQ-9 for depression using mobile devices.Patients and Methods: We found all published and unpublished studies through EMBASE, MEDLINE, MEDLINE In-Process, and PsychINFO up to March 26, 2021. We performed a meta-analysis by including 1099 subjects in four studies. We performed a diagnostic meta-analysis according to the PHQ-9 cut-off score and machine learning algorithm techniques. Quality assessment was conducted using the QUADAS-2 tool. Data on the sensitivity and specificity of the studies included in the meta-analysis were extracted in a standardized format. Bivariate and summary receiver operating characteristic (SROC) curve were constructed using the metandi, midas, metabias, and metareg functions of the Stata algorithm meta-analysis words.Results: Using four studies out of the 5476 papers searched, a diagnostic meta-analysis of the PHQ-9 scores of 1099 people diagnosed with depression was performed. The pooled sensitivity and specificity were 0.797 (95% CI = 0.642– 0.895) and 0.85 (95% CI = 0.780– 0.900), respectively. The diagnostic odds ratio was 22.16 (95% CI = 7.273– 67.499). Overall, a good balance was maintained, and no heterogeneity or publication bias was presented.Conclusion: Through various machine learning algorithm techniques, it was possible to confirm that PHQ-9 depression screening in mobiles is an effective diagnostic tool when integrated into a diagnostic meta-analysis.Keywords: diagnostic meta-analysis, depression, Patient Health Questionnaire-9, machine learning, mobile, diagnosis |
format |
article |
author |
Kim S Lee K |
author_facet |
Kim S Lee K |
author_sort |
Kim S |
title |
Screening for Depression in Mobile Devices Using Patient Health Questionnaire-9 (PHQ-9) Data: A Diagnostic Meta-Analysis via Machine Learning Methods |
title_short |
Screening for Depression in Mobile Devices Using Patient Health Questionnaire-9 (PHQ-9) Data: A Diagnostic Meta-Analysis via Machine Learning Methods |
title_full |
Screening for Depression in Mobile Devices Using Patient Health Questionnaire-9 (PHQ-9) Data: A Diagnostic Meta-Analysis via Machine Learning Methods |
title_fullStr |
Screening for Depression in Mobile Devices Using Patient Health Questionnaire-9 (PHQ-9) Data: A Diagnostic Meta-Analysis via Machine Learning Methods |
title_full_unstemmed |
Screening for Depression in Mobile Devices Using Patient Health Questionnaire-9 (PHQ-9) Data: A Diagnostic Meta-Analysis via Machine Learning Methods |
title_sort |
screening for depression in mobile devices using patient health questionnaire-9 (phq-9) data: a diagnostic meta-analysis via machine learning methods |
publisher |
Dove Medical Press |
publishDate |
2021 |
url |
https://doaj.org/article/32620ae534c2428a96db7434a1104356 |
work_keys_str_mv |
AT kims screeningfordepressioninmobiledevicesusingpatienthealthquestionnaire9phq9dataadiagnosticmetaanalysisviamachinelearningmethods AT leek screeningfordepressioninmobiledevicesusingpatienthealthquestionnaire9phq9dataadiagnosticmetaanalysisviamachinelearningmethods |
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