The pan-cancer landscape of crosstalk between epithelial-mesenchymal transition and immune evasion relevant to prognosis and immunotherapy response

Abstract An emerging body of evidence has recently recognized the coexistence of epithelial-mesenchymal transition (EMT) and immune response. However, a systems-level view and survey of the interplay between EMT and immune escape program, and their impact on tumor behavior and clinical outcome acros...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Guangyu Wang, Dandan Xu, Zicheng Zhang, Xinhui Li, Jiaqi Shi, Jie Sun, Huan-Zhong Liu, Xiaobo Li, Meng Zhou, Tongsen Zheng
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/3264fe39908f46e184a6d431d2115a42
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:3264fe39908f46e184a6d431d2115a42
record_format	dspace
spelling	oai:doaj.org-article:3264fe39908f46e184a6d431d2115a422021-12-02T16:05:49ZThe pan-cancer landscape of crosstalk between epithelial-mesenchymal transition and immune evasion relevant to prognosis and immunotherapy response10.1038/s41698-021-00200-42397-768Xhttps://doaj.org/article/3264fe39908f46e184a6d431d2115a422021-06-01T00:00:00Zhttps://doi.org/10.1038/s41698-021-00200-4https://doaj.org/toc/2397-768XAbstract An emerging body of evidence has recently recognized the coexistence of epithelial-mesenchymal transition (EMT) and immune response. However, a systems-level view and survey of the interplay between EMT and immune escape program, and their impact on tumor behavior and clinical outcome across various types of cancer is lacking. Here, we performed comprehensive multi-omics analyses to characterize the landscape of crosstalk between EMT and immune evasion and their clinical relevance across 17 types of solid cancer. Our study showed the presence of complex and dynamic immunomodulatory crosstalk between EMT and immune evasion shared by pan-cancer, and the crosstalk was significantly associated with cancer prognosis and immunotherapy response. Integrative quantitative analyses of genomics and immunogenomics revealed that cellular composition of immune infiltrates, non-synonymous mutation burden, chromosomal instability and oncogenic gene alterations are associated with the balance between EMT and immune evasion. Finally, we proposed a scoring model termed EMT-CYT Index (ECI) to quantify the EMT-immunity axis, which was a superior predictor of prognosis and immunotherapy response across different malignancies. By providing a systematic overview of crosstalk between EMT and immune evasion, our study highlights the potential of pan-cancer EMT-immunity crosstalk as a paradigm for dissecting molecular mechanisms underlying cancer progression and guiding more effective and generalized immunotherapy strategies.Guangyu WangDandan XuZicheng ZhangXinhui LiJiaqi ShiJie SunHuan-Zhong LiuXiaobo LiMeng ZhouTongsen ZhengNature PortfolioarticleNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENnpj Precision Oncology, Vol 5, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Guangyu Wang Dandan Xu Zicheng Zhang Xinhui Li Jiaqi Shi Jie Sun Huan-Zhong Liu Xiaobo Li Meng Zhou Tongsen Zheng The pan-cancer landscape of crosstalk between epithelial-mesenchymal transition and immune evasion relevant to prognosis and immunotherapy response
description	Abstract An emerging body of evidence has recently recognized the coexistence of epithelial-mesenchymal transition (EMT) and immune response. However, a systems-level view and survey of the interplay between EMT and immune escape program, and their impact on tumor behavior and clinical outcome across various types of cancer is lacking. Here, we performed comprehensive multi-omics analyses to characterize the landscape of crosstalk between EMT and immune evasion and their clinical relevance across 17 types of solid cancer. Our study showed the presence of complex and dynamic immunomodulatory crosstalk between EMT and immune evasion shared by pan-cancer, and the crosstalk was significantly associated with cancer prognosis and immunotherapy response. Integrative quantitative analyses of genomics and immunogenomics revealed that cellular composition of immune infiltrates, non-synonymous mutation burden, chromosomal instability and oncogenic gene alterations are associated with the balance between EMT and immune evasion. Finally, we proposed a scoring model termed EMT-CYT Index (ECI) to quantify the EMT-immunity axis, which was a superior predictor of prognosis and immunotherapy response across different malignancies. By providing a systematic overview of crosstalk between EMT and immune evasion, our study highlights the potential of pan-cancer EMT-immunity crosstalk as a paradigm for dissecting molecular mechanisms underlying cancer progression and guiding more effective and generalized immunotherapy strategies.
format	article
author	Guangyu Wang Dandan Xu Zicheng Zhang Xinhui Li Jiaqi Shi Jie Sun Huan-Zhong Liu Xiaobo Li Meng Zhou Tongsen Zheng
author_facet	Guangyu Wang Dandan Xu Zicheng Zhang Xinhui Li Jiaqi Shi Jie Sun Huan-Zhong Liu Xiaobo Li Meng Zhou Tongsen Zheng
author_sort	Guangyu Wang
title	The pan-cancer landscape of crosstalk between epithelial-mesenchymal transition and immune evasion relevant to prognosis and immunotherapy response
title_short	The pan-cancer landscape of crosstalk between epithelial-mesenchymal transition and immune evasion relevant to prognosis and immunotherapy response
title_full	The pan-cancer landscape of crosstalk between epithelial-mesenchymal transition and immune evasion relevant to prognosis and immunotherapy response
title_fullStr	The pan-cancer landscape of crosstalk between epithelial-mesenchymal transition and immune evasion relevant to prognosis and immunotherapy response
title_full_unstemmed	The pan-cancer landscape of crosstalk between epithelial-mesenchymal transition and immune evasion relevant to prognosis and immunotherapy response
title_sort	pan-cancer landscape of crosstalk between epithelial-mesenchymal transition and immune evasion relevant to prognosis and immunotherapy response
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/3264fe39908f46e184a6d431d2115a42
work_keys_str_mv	AT guangyuwang thepancancerlandscapeofcrosstalkbetweenepithelialmesenchymaltransitionandimmuneevasionrelevanttoprognosisandimmunotherapyresponse AT dandanxu thepancancerlandscapeofcrosstalkbetweenepithelialmesenchymaltransitionandimmuneevasionrelevanttoprognosisandimmunotherapyresponse AT zichengzhang thepancancerlandscapeofcrosstalkbetweenepithelialmesenchymaltransitionandimmuneevasionrelevanttoprognosisandimmunotherapyresponse AT xinhuili thepancancerlandscapeofcrosstalkbetweenepithelialmesenchymaltransitionandimmuneevasionrelevanttoprognosisandimmunotherapyresponse AT jiaqishi thepancancerlandscapeofcrosstalkbetweenepithelialmesenchymaltransitionandimmuneevasionrelevanttoprognosisandimmunotherapyresponse AT jiesun thepancancerlandscapeofcrosstalkbetweenepithelialmesenchymaltransitionandimmuneevasionrelevanttoprognosisandimmunotherapyresponse AT huanzhongliu thepancancerlandscapeofcrosstalkbetweenepithelialmesenchymaltransitionandimmuneevasionrelevanttoprognosisandimmunotherapyresponse AT xiaoboli thepancancerlandscapeofcrosstalkbetweenepithelialmesenchymaltransitionandimmuneevasionrelevanttoprognosisandimmunotherapyresponse AT mengzhou thepancancerlandscapeofcrosstalkbetweenepithelialmesenchymaltransitionandimmuneevasionrelevanttoprognosisandimmunotherapyresponse AT tongsenzheng thepancancerlandscapeofcrosstalkbetweenepithelialmesenchymaltransitionandimmuneevasionrelevanttoprognosisandimmunotherapyresponse AT guangyuwang pancancerlandscapeofcrosstalkbetweenepithelialmesenchymaltransitionandimmuneevasionrelevanttoprognosisandimmunotherapyresponse AT dandanxu pancancerlandscapeofcrosstalkbetweenepithelialmesenchymaltransitionandimmuneevasionrelevanttoprognosisandimmunotherapyresponse AT zichengzhang pancancerlandscapeofcrosstalkbetweenepithelialmesenchymaltransitionandimmuneevasionrelevanttoprognosisandimmunotherapyresponse AT xinhuili pancancerlandscapeofcrosstalkbetweenepithelialmesenchymaltransitionandimmuneevasionrelevanttoprognosisandimmunotherapyresponse AT jiaqishi pancancerlandscapeofcrosstalkbetweenepithelialmesenchymaltransitionandimmuneevasionrelevanttoprognosisandimmunotherapyresponse AT jiesun pancancerlandscapeofcrosstalkbetweenepithelialmesenchymaltransitionandimmuneevasionrelevanttoprognosisandimmunotherapyresponse AT huanzhongliu pancancerlandscapeofcrosstalkbetweenepithelialmesenchymaltransitionandimmuneevasionrelevanttoprognosisandimmunotherapyresponse AT xiaoboli pancancerlandscapeofcrosstalkbetweenepithelialmesenchymaltransitionandimmuneevasionrelevanttoprognosisandimmunotherapyresponse AT mengzhou pancancerlandscapeofcrosstalkbetweenepithelialmesenchymaltransitionandimmuneevasionrelevanttoprognosisandimmunotherapyresponse AT tongsenzheng pancancerlandscapeofcrosstalkbetweenepithelialmesenchymaltransitionandimmuneevasionrelevanttoprognosisandimmunotherapyresponse
_version_	1718385138101911552

The pan-cancer landscape of crosstalk between epithelial-mesenchymal transition and immune evasion relevant to prognosis and immunotherapy response

Ejemplares similares