Determinants of renal cell carcinoma invasion and metastatic competence
Tumour thrombi (TT) are intravascular extensions of renal cell carcinomas (RCC) which often lead to distant metastases. Here the authors examine the determinants of vascular invasion and metastasis in a unique cohort of RCC patients with TT using multi-region genomics and in vivo models.
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Nature Portfolio
2021
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oai:doaj.org-article:3266527d43244260bdb0306af8f05a4d2021-12-02T18:01:53ZDeterminants of renal cell carcinoma invasion and metastatic competence10.1038/s41467-021-25918-42041-1723https://doaj.org/article/3266527d43244260bdb0306af8f05a4d2021-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25918-4https://doaj.org/toc/2041-1723Tumour thrombi (TT) are intravascular extensions of renal cell carcinomas (RCC) which often lead to distant metastases. Here the authors examine the determinants of vascular invasion and metastasis in a unique cohort of RCC patients with TT using multi-region genomics and in vivo models.Kangsan KimQinbo ZhouAlana ChristieChristina StevensYuanqing MaOreoluwa OnaboluSuneetha ChintalapatiTiffani MckenzieVanina Toffessi TcheuyapLayton WoolfordHe ZhangNirmish SinglaPravat Kumar ParidaMauricio Marquez-PalenciaIvan PedrosaVitaly MargulisArthur SagalowskyZhiqun XieTao WangSteffen DurinckZora ModrusanSomasekar SeshagiriPayal KapurJames BrugarolasSrinivas MalladiNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Kangsan Kim Qinbo Zhou Alana Christie Christina Stevens Yuanqing Ma Oreoluwa Onabolu Suneetha Chintalapati Tiffani Mckenzie Vanina Toffessi Tcheuyap Layton Woolford He Zhang Nirmish Singla Pravat Kumar Parida Mauricio Marquez-Palencia Ivan Pedrosa Vitaly Margulis Arthur Sagalowsky Zhiqun Xie Tao Wang Steffen Durinck Zora Modrusan Somasekar Seshagiri Payal Kapur James Brugarolas Srinivas Malladi Determinants of renal cell carcinoma invasion and metastatic competence |
| description |
Tumour thrombi (TT) are intravascular extensions of renal cell carcinomas (RCC) which often lead to distant metastases. Here the authors examine the determinants of vascular invasion and metastasis in a unique cohort of RCC patients with TT using multi-region genomics and in vivo models. |
| format |
article |
| author |
Kangsan Kim Qinbo Zhou Alana Christie Christina Stevens Yuanqing Ma Oreoluwa Onabolu Suneetha Chintalapati Tiffani Mckenzie Vanina Toffessi Tcheuyap Layton Woolford He Zhang Nirmish Singla Pravat Kumar Parida Mauricio Marquez-Palencia Ivan Pedrosa Vitaly Margulis Arthur Sagalowsky Zhiqun Xie Tao Wang Steffen Durinck Zora Modrusan Somasekar Seshagiri Payal Kapur James Brugarolas Srinivas Malladi |
| author_facet |
Kangsan Kim Qinbo Zhou Alana Christie Christina Stevens Yuanqing Ma Oreoluwa Onabolu Suneetha Chintalapati Tiffani Mckenzie Vanina Toffessi Tcheuyap Layton Woolford He Zhang Nirmish Singla Pravat Kumar Parida Mauricio Marquez-Palencia Ivan Pedrosa Vitaly Margulis Arthur Sagalowsky Zhiqun Xie Tao Wang Steffen Durinck Zora Modrusan Somasekar Seshagiri Payal Kapur James Brugarolas Srinivas Malladi |
| author_sort |
Kangsan Kim |
| title |
Determinants of renal cell carcinoma invasion and metastatic competence |
| title_short |
Determinants of renal cell carcinoma invasion and metastatic competence |
| title_full |
Determinants of renal cell carcinoma invasion and metastatic competence |
| title_fullStr |
Determinants of renal cell carcinoma invasion and metastatic competence |
| title_full_unstemmed |
Determinants of renal cell carcinoma invasion and metastatic competence |
| title_sort |
determinants of renal cell carcinoma invasion and metastatic competence |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/3266527d43244260bdb0306af8f05a4d |
| work_keys_str_mv |
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