Peritoneal dialysis modality transition and impact on phosphate and potassium serum levels.
Peritoneal dialysis (PD) modalities affect solute removal differently. However, the impacts of switching PD modalities on serum levels of biomarkers of different sizes are not known. Our objective was to analyze whether a change in the PD modality associates with the levels of two routine biochemica...
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2021
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oai:doaj.org-article:326762091327410e84c01aa150dfedd02021-12-02T20:16:53ZPeritoneal dialysis modality transition and impact on phosphate and potassium serum levels.1932-620310.1371/journal.pone.0257140https://doaj.org/article/326762091327410e84c01aa150dfedd02021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0257140https://doaj.org/toc/1932-6203Peritoneal dialysis (PD) modalities affect solute removal differently. However, the impacts of switching PD modalities on serum levels of biomarkers of different sizes are not known. Our objective was to analyze whether a change in the PD modality associates with the levels of two routine biochemical laboratories. In this multicentric prospective cohort study. we selected all patients who remained on a PD modality for at least 6 months and switched PD modality. Patients were also required to be treated with the same PD modality for at least 3 months before and after the modality change. The primary outcome was change in potassium and phosphate serum levels. We identified 737 eligible patients who switched their PD modality during the study. We found mean serum phosphate levels increased during the 3 months after switching from CAPD to APD and conversely decreased after switching to from APD to CAPD. In contrast, for potassium the difference in the mean serum levels was comparable between groups switching from CAPD to APD, and vice versa. In conclusion, CAPD seems to be as efficient as APD for the control of potassium serum levels, but more effective for the control of phosphate serum levels. The effect of a higher removal of middle size molecules as result of PD modalities in terms of clinical and patient-reported outcomes should be further explored.Daniela PeruzzoMurilo GuedesJohn W LarkinGuilherme YokoyamaTaynara Lopes Dos SantosRoberto Pecoits-FilhoSilvia Carreira RibeiroAlfonso RamosPasqual BarrettiThyago Proença de MoraesBRAZPD InvestigatorsPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 10, p e0257140 (2021) |
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DOAJ |
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Medicine R Science Q |
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Medicine R Science Q Daniela Peruzzo Murilo Guedes John W Larkin Guilherme Yokoyama Taynara Lopes Dos Santos Roberto Pecoits-Filho Silvia Carreira Ribeiro Alfonso Ramos Pasqual Barretti Thyago Proença de Moraes BRAZPD Investigators Peritoneal dialysis modality transition and impact on phosphate and potassium serum levels. |
| description |
Peritoneal dialysis (PD) modalities affect solute removal differently. However, the impacts of switching PD modalities on serum levels of biomarkers of different sizes are not known. Our objective was to analyze whether a change in the PD modality associates with the levels of two routine biochemical laboratories. In this multicentric prospective cohort study. we selected all patients who remained on a PD modality for at least 6 months and switched PD modality. Patients were also required to be treated with the same PD modality for at least 3 months before and after the modality change. The primary outcome was change in potassium and phosphate serum levels. We identified 737 eligible patients who switched their PD modality during the study. We found mean serum phosphate levels increased during the 3 months after switching from CAPD to APD and conversely decreased after switching to from APD to CAPD. In contrast, for potassium the difference in the mean serum levels was comparable between groups switching from CAPD to APD, and vice versa. In conclusion, CAPD seems to be as efficient as APD for the control of potassium serum levels, but more effective for the control of phosphate serum levels. The effect of a higher removal of middle size molecules as result of PD modalities in terms of clinical and patient-reported outcomes should be further explored. |
| format |
article |
| author |
Daniela Peruzzo Murilo Guedes John W Larkin Guilherme Yokoyama Taynara Lopes Dos Santos Roberto Pecoits-Filho Silvia Carreira Ribeiro Alfonso Ramos Pasqual Barretti Thyago Proença de Moraes BRAZPD Investigators |
| author_facet |
Daniela Peruzzo Murilo Guedes John W Larkin Guilherme Yokoyama Taynara Lopes Dos Santos Roberto Pecoits-Filho Silvia Carreira Ribeiro Alfonso Ramos Pasqual Barretti Thyago Proença de Moraes BRAZPD Investigators |
| author_sort |
Daniela Peruzzo |
| title |
Peritoneal dialysis modality transition and impact on phosphate and potassium serum levels. |
| title_short |
Peritoneal dialysis modality transition and impact on phosphate and potassium serum levels. |
| title_full |
Peritoneal dialysis modality transition and impact on phosphate and potassium serum levels. |
| title_fullStr |
Peritoneal dialysis modality transition and impact on phosphate and potassium serum levels. |
| title_full_unstemmed |
Peritoneal dialysis modality transition and impact on phosphate and potassium serum levels. |
| title_sort |
peritoneal dialysis modality transition and impact on phosphate and potassium serum levels. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2021 |
| url |
https://doaj.org/article/326762091327410e84c01aa150dfedd0 |
| work_keys_str_mv |
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| _version_ |
1718374396584787968 |