Plasma Lipoprotein(a) Levels as Determinants of Arterial Stiffening in Hypertension

Previous studies have shown that plasma lipoprotein(a) (Lp(a)) plays an important role in the development of hypertensive organ damage. The aim of the present study was to investigate the relationship of Lp(a) with markers of arterial stiffening in hypertension. In 138 essential hypertensive patient...

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Autores principales:	Gabriele Brosolo, Andrea Da Porto, Luca Bulfone, Antonio Vacca, Nicole Bertin, Gianluca Colussi, Alessandro Cavarape, Leonardo A. Sechi, Cristiana Catena
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	arterial stiffness augmentation index hypertension lipoprotein(a) pulse wave velocity Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/3269ab0900e3443ea9e58495113f4363
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id	oai:doaj.org-article:3269ab0900e3443ea9e58495113f4363
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spelling	oai:doaj.org-article:3269ab0900e3443ea9e58495113f43632021-11-25T16:48:23ZPlasma Lipoprotein(a) Levels as Determinants of Arterial Stiffening in Hypertension10.3390/biomedicines91115102227-9059https://doaj.org/article/3269ab0900e3443ea9e58495113f43632021-10-01T00:00:00Zhttps://www.mdpi.com/2227-9059/9/11/1510https://doaj.org/toc/2227-9059Previous studies have shown that plasma lipoprotein(a) (Lp(a)) plays an important role in the development of hypertensive organ damage. The aim of the present study was to investigate the relationship of Lp(a) with markers of arterial stiffening in hypertension. In 138 essential hypertensive patients free of diabetes, renal failure and cardiovascular complications, we measured plasma lipids and assessed vascular stiffness through the use of pulse wave analysis and calculation of the brachial augmentation index (AIx), and measured the pulse wave velocity (PWV). Plasma Lp(a) levels were significantly and directly related to both AIx (<i>r</i> = 0.490; <i>p</i> < 0.001) and PWV (<i>r</i> = 0.212; <i>p</i> = 0.013). Multiple regression analysis showed that AIx was independently correlated with age, C-reactive protein, and plasma Lp(a) (beta 0.326; <i>p</i> < 0.001), while PWV was independently and directly correlated with age, and inversely with HDL, but not with plasma Lp(a). Logistic regression indicated that plasma Lp(a) could predict an AIx value above the median for the distribution (<i>p</i> = 0.026). Thus, in a highly selective group of patients with hypertension, plasma Lp(a) levels were significantly and directly related to markers of vascular stiffening. Because of the relevance of vascular stiffening to cardiovascular risk, the reduction of Lp(a) levels might be beneficial for cardiovascular protection in patients with hypertension.Gabriele BrosoloAndrea Da PortoLuca BulfoneAntonio VaccaNicole BertinGianluca ColussiAlessandro CavarapeLeonardo A. SechiCristiana CatenaMDPI AGarticlearterial stiffnessaugmentation indexhypertensionlipoprotein(a)pulse wave velocityBiology (General)QH301-705.5ENBiomedicines, Vol 9, Iss 1510, p 1510 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	arterial stiffness augmentation index hypertension lipoprotein(a) pulse wave velocity Biology (General) QH301-705.5
spellingShingle	arterial stiffness augmentation index hypertension lipoprotein(a) pulse wave velocity Biology (General) QH301-705.5 Gabriele Brosolo Andrea Da Porto Luca Bulfone Antonio Vacca Nicole Bertin Gianluca Colussi Alessandro Cavarape Leonardo A. Sechi Cristiana Catena Plasma Lipoprotein(a) Levels as Determinants of Arterial Stiffening in Hypertension
description	Previous studies have shown that plasma lipoprotein(a) (Lp(a)) plays an important role in the development of hypertensive organ damage. The aim of the present study was to investigate the relationship of Lp(a) with markers of arterial stiffening in hypertension. In 138 essential hypertensive patients free of diabetes, renal failure and cardiovascular complications, we measured plasma lipids and assessed vascular stiffness through the use of pulse wave analysis and calculation of the brachial augmentation index (AIx), and measured the pulse wave velocity (PWV). Plasma Lp(a) levels were significantly and directly related to both AIx (<i>r</i> = 0.490; <i>p</i> < 0.001) and PWV (<i>r</i> = 0.212; <i>p</i> = 0.013). Multiple regression analysis showed that AIx was independently correlated with age, C-reactive protein, and plasma Lp(a) (beta 0.326; <i>p</i> < 0.001), while PWV was independently and directly correlated with age, and inversely with HDL, but not with plasma Lp(a). Logistic regression indicated that plasma Lp(a) could predict an AIx value above the median for the distribution (<i>p</i> = 0.026). Thus, in a highly selective group of patients with hypertension, plasma Lp(a) levels were significantly and directly related to markers of vascular stiffening. Because of the relevance of vascular stiffening to cardiovascular risk, the reduction of Lp(a) levels might be beneficial for cardiovascular protection in patients with hypertension.
format	article
author	Gabriele Brosolo Andrea Da Porto Luca Bulfone Antonio Vacca Nicole Bertin Gianluca Colussi Alessandro Cavarape Leonardo A. Sechi Cristiana Catena
author_facet	Gabriele Brosolo Andrea Da Porto Luca Bulfone Antonio Vacca Nicole Bertin Gianluca Colussi Alessandro Cavarape Leonardo A. Sechi Cristiana Catena
author_sort	Gabriele Brosolo
title	Plasma Lipoprotein(a) Levels as Determinants of Arterial Stiffening in Hypertension
title_short	Plasma Lipoprotein(a) Levels as Determinants of Arterial Stiffening in Hypertension
title_full	Plasma Lipoprotein(a) Levels as Determinants of Arterial Stiffening in Hypertension
title_fullStr	Plasma Lipoprotein(a) Levels as Determinants of Arterial Stiffening in Hypertension
title_full_unstemmed	Plasma Lipoprotein(a) Levels as Determinants of Arterial Stiffening in Hypertension
title_sort	plasma lipoprotein(a) levels as determinants of arterial stiffening in hypertension
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/3269ab0900e3443ea9e58495113f4363
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Plasma Lipoprotein(a) Levels as Determinants of Arterial Stiffening in Hypertension

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