Genome-wide association study identifies risk loci for progressive chronic lymphocytic leukemia
The clinical course of chronic lymphocytic leukaemia (CLL) is variable and difficult to predict. Here, the authors conduct a genome wide association study meta-analysis for time to first treatment in CLL patients and report two loci associating with progressive disease.
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Nature Portfolio
2021
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oai:doaj.org-article:326c1d18f1cc498d8b36824ed27e2e042021-12-02T10:47:58ZGenome-wide association study identifies risk loci for progressive chronic lymphocytic leukemia10.1038/s41467-020-20822-92041-1723https://doaj.org/article/326c1d18f1cc498d8b36824ed27e2e042021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20822-9https://doaj.org/toc/2041-1723The clinical course of chronic lymphocytic leukaemia (CLL) is variable and difficult to predict. Here, the authors conduct a genome wide association study meta-analysis for time to first treatment in CLL patients and report two loci associating with progressive disease.Wei-Yu LinSarah E. FordhamNicola SunterClaire ElstobThahira RahmanElaine WillmoreColin ShepherdGordon StrathdeeTryfonia Mainou-FowlerRachel PiddockHannah MearnsTimothy BarrowRichard S. HoulstonHelen MarrJonathan WallisGeoffrey SummerfieldScott MarshallAndrew PettittChristopher PepperChristopher FeganFrancesco ForconiMartin J. S. DyerSandrine JayneApril SellorsAnna SchuhPauline RobbeDavid OscierJames BaileySyed RaisAlison BentleyLynn CawkwellPaul EvansPeter HillmenGuy PrattDavid J. AllsupJames M. AllanNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-8 (2021) |
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DOAJ |
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DOAJ |
| language |
EN |
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Science Q |
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Science Q Wei-Yu Lin Sarah E. Fordham Nicola Sunter Claire Elstob Thahira Rahman Elaine Willmore Colin Shepherd Gordon Strathdee Tryfonia Mainou-Fowler Rachel Piddock Hannah Mearns Timothy Barrow Richard S. Houlston Helen Marr Jonathan Wallis Geoffrey Summerfield Scott Marshall Andrew Pettitt Christopher Pepper Christopher Fegan Francesco Forconi Martin J. S. Dyer Sandrine Jayne April Sellors Anna Schuh Pauline Robbe David Oscier James Bailey Syed Rais Alison Bentley Lynn Cawkwell Paul Evans Peter Hillmen Guy Pratt David J. Allsup James M. Allan Genome-wide association study identifies risk loci for progressive chronic lymphocytic leukemia |
| description |
The clinical course of chronic lymphocytic leukaemia (CLL) is variable and difficult to predict. Here, the authors conduct a genome wide association study meta-analysis for time to first treatment in CLL patients and report two loci associating with progressive disease. |
| format |
article |
| author |
Wei-Yu Lin Sarah E. Fordham Nicola Sunter Claire Elstob Thahira Rahman Elaine Willmore Colin Shepherd Gordon Strathdee Tryfonia Mainou-Fowler Rachel Piddock Hannah Mearns Timothy Barrow Richard S. Houlston Helen Marr Jonathan Wallis Geoffrey Summerfield Scott Marshall Andrew Pettitt Christopher Pepper Christopher Fegan Francesco Forconi Martin J. S. Dyer Sandrine Jayne April Sellors Anna Schuh Pauline Robbe David Oscier James Bailey Syed Rais Alison Bentley Lynn Cawkwell Paul Evans Peter Hillmen Guy Pratt David J. Allsup James M. Allan |
| author_facet |
Wei-Yu Lin Sarah E. Fordham Nicola Sunter Claire Elstob Thahira Rahman Elaine Willmore Colin Shepherd Gordon Strathdee Tryfonia Mainou-Fowler Rachel Piddock Hannah Mearns Timothy Barrow Richard S. Houlston Helen Marr Jonathan Wallis Geoffrey Summerfield Scott Marshall Andrew Pettitt Christopher Pepper Christopher Fegan Francesco Forconi Martin J. S. Dyer Sandrine Jayne April Sellors Anna Schuh Pauline Robbe David Oscier James Bailey Syed Rais Alison Bentley Lynn Cawkwell Paul Evans Peter Hillmen Guy Pratt David J. Allsup James M. Allan |
| author_sort |
Wei-Yu Lin |
| title |
Genome-wide association study identifies risk loci for progressive chronic lymphocytic leukemia |
| title_short |
Genome-wide association study identifies risk loci for progressive chronic lymphocytic leukemia |
| title_full |
Genome-wide association study identifies risk loci for progressive chronic lymphocytic leukemia |
| title_fullStr |
Genome-wide association study identifies risk loci for progressive chronic lymphocytic leukemia |
| title_full_unstemmed |
Genome-wide association study identifies risk loci for progressive chronic lymphocytic leukemia |
| title_sort |
genome-wide association study identifies risk loci for progressive chronic lymphocytic leukemia |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/326c1d18f1cc498d8b36824ed27e2e04 |
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