The Influence of Nanostructured Hydroxyapatite Surface in the Early Stages of Osseointegration: A Multiparameter Animal Study in Low-Density Bone

Suelen Cristina Sartoretto,1– 4 Jose Calasans-Maia,5 Rodrigo Resende,2,4,6 Eduardo Câmara,3 Bruna Ghiraldini,7 Fabio Jose Barbosa Bezerra,8 Jose Mauro Granjeiro,4,9 Monica Diuana Calasans-Maia4,6 1Oral Surgery Department, Universidade Veiga de Almeida, Rio de Janeiro, RJ, Brazil;...

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Autores principales:	Sartoretto SC, Calasans-Maia J, Resende R, Câmara E, Ghiraldini B, Barbosa Bezerra FJ, Granjeiro JM, Calasans-Maia MD
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	osseointegration dental implant surface nanotechnology hydroxyapatite sheep bone response Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/326dda774b254150821f63a99cbdf410
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id	oai:doaj.org-article:326dda774b254150821f63a99cbdf410
record_format	dspace
institution	DOAJ
collection	DOAJ
language	EN
topic	osseointegration dental implant surface nanotechnology hydroxyapatite sheep bone response Medicine (General) R5-920
spellingShingle	osseointegration dental implant surface nanotechnology hydroxyapatite sheep bone response Medicine (General) R5-920 Sartoretto SC Calasans-Maia J Resende R Câmara E Ghiraldini B Barbosa Bezerra FJ Granjeiro JM Calasans-Maia MD The Influence of Nanostructured Hydroxyapatite Surface in the Early Stages of Osseointegration: A Multiparameter Animal Study in Low-Density Bone
description	Suelen Cristina Sartoretto,1– 4 Jose Calasans-Maia,5 Rodrigo Resende,2,4,6 Eduardo Câmara,3 Bruna Ghiraldini,7 Fabio Jose Barbosa Bezerra,8 Jose Mauro Granjeiro,4,9 Monica Diuana Calasans-Maia4,6 1Oral Surgery Department, Universidade Veiga de Almeida, Rio de Janeiro, RJ, Brazil; 2Oral Surgery Department, Universidade Iguaçu, Nova Iguaçu, RJ, Brazil; 3Post-Graduation Program in Dentistry, Universidade Veiga de Almeida, Rio de Janeiro, RJ, Brazil; 4Clinical Research Laboratory, Dentistry School, Universidade Federal Fluminense, Niteroi, RJ, Brazil; 5Orthodontics Department, Dentistry School, Universidade Federal Fluminense, Niteroi, RJ, Brazil; 6Oral Surgery Department, Universidade Federal Fluminense, Niteroi, RJ, Brazil; 7Dental Research Division, Dentistry School, Universidade Paulista, São Paulo, SP, Brazil; 8Laboratory of Bioassays and Cell Dynamics, IBB-UNESP, Botucatu, Brazil; 9National Institute of Metrology, Quality and Technology (INMETRO), Duque de Caxias, RJ, BrazilCorrespondence: Monica Diuana Calasans-Maia; Jose Mauro GranjeiroUniversidade Federal Fluminense, Rua Mario Santos Braga, 28/4 Floor, Niteroi, RJ, BrazilTel +55 21 98153-5884Email monicacalasansmaia@gmail.com; jmgranjeiro@gmail.comBackground and Objective: The success rates of dental implants in low-density bone have been reported as a challenge, especially for early or immediate loading in the maxilla posterior area. Nanoscale architecture affects the roughness, surface area, surface energy of the implant and can enhance osseointegration. This study aimed to evaluate the implant-surface topography and biomechanical, histomorphometric, and histological bone responses to a new nanostructured hydroxyapatite surface placed in the iliac crest of sheep.Methods: Ten female sheep (2– 4 years) received 30 implants (n=10/group): HAnano® coated (Epikut Plus®, S.I.N. Implant System, Sao Paulo, SP, Brazil), SLActive (BLX®, Straumann, Basel, Switzerland), and TiUnite (NobelActive®, Nobel Biocare, Göteborg, Sweden) surfaces. Scanning electron microscopy with energy-dispersive spectroscopy evaluated the implant surface topography, the insertion torque value, and resonance frequency analysis evaluated the primary stability, bone-implant contact, and bone-area fraction occupancy were evaluated after 14 and 28 days after implant placement.Results: The surface morphology was considerably comparable between the implant groups’; however, the TiUnite® group presented a remarkable different surface. The SLActive® and TiUnite® groups presented an insertion torque average of 74 (± 8.9) N/cm that was similar to that of HAnano® 72 (± 8.3) N/cm (p > 0.05). The resonance frequency evaluated with Osstell®/SmartPeg® or Penguin®/MulTipeg® showed similar results when assessing implants from the same group. BIC and BAFO significantly increased (p< 0.05) throughout the experimental periods to all groups, but BIC and BAFO values were similar among the implants at the same time point. After 4 weeks, bone-implant contact was higher than 80% of the total length analyzed. New bone occupies around 60% of analyzed area around the implants.Conclusion: HAnano® coated surface promoted comparable osseointegration as SLActive and TiUnite in the sheep model. The three tested surfaces showed comparable osseointegration at the early stages of low-density bone repair in the sheep model.Keywords: osseointegration, dental implant surface, nanotechnology, hydroxyapatite, sheep, bone response
format	article
author	Sartoretto SC Calasans-Maia J Resende R Câmara E Ghiraldini B Barbosa Bezerra FJ Granjeiro JM Calasans-Maia MD
author_facet	Sartoretto SC Calasans-Maia J Resende R Câmara E Ghiraldini B Barbosa Bezerra FJ Granjeiro JM Calasans-Maia MD
author_sort	Sartoretto SC
title	The Influence of Nanostructured Hydroxyapatite Surface in the Early Stages of Osseointegration: A Multiparameter Animal Study in Low-Density Bone
title_short	The Influence of Nanostructured Hydroxyapatite Surface in the Early Stages of Osseointegration: A Multiparameter Animal Study in Low-Density Bone
title_full	The Influence of Nanostructured Hydroxyapatite Surface in the Early Stages of Osseointegration: A Multiparameter Animal Study in Low-Density Bone
title_fullStr	The Influence of Nanostructured Hydroxyapatite Surface in the Early Stages of Osseointegration: A Multiparameter Animal Study in Low-Density Bone
title_full_unstemmed	The Influence of Nanostructured Hydroxyapatite Surface in the Early Stages of Osseointegration: A Multiparameter Animal Study in Low-Density Bone
title_sort	influence of nanostructured hydroxyapatite surface in the early stages of osseointegration: a multiparameter animal study in low-density bone
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/326dda774b254150821f63a99cbdf410
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spelling	oai:doaj.org-article:326dda774b254150821f63a99cbdf4102021-12-02T12:28:51ZThe Influence of Nanostructured Hydroxyapatite Surface in the Early Stages of Osseointegration: A Multiparameter Animal Study in Low-Density Bone1178-2013https://doaj.org/article/326dda774b254150821f63a99cbdf4102020-11-01T00:00:00Zhttps://www.dovepress.com/the-influence-of-nanostructured-hydroxyapatite-surface-in-the-early-st-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Suelen Cristina Sartoretto,1– 4 Jose Calasans-Maia,5 Rodrigo Resende,2,4,6 Eduardo Câmara,3 Bruna Ghiraldini,7 Fabio Jose Barbosa Bezerra,8 Jose Mauro Granjeiro,4,9 Monica Diuana Calasans-Maia4,6 1Oral Surgery Department, Universidade Veiga de Almeida, Rio de Janeiro, RJ, Brazil; 2Oral Surgery Department, Universidade Iguaçu, Nova Iguaçu, RJ, Brazil; 3Post-Graduation Program in Dentistry, Universidade Veiga de Almeida, Rio de Janeiro, RJ, Brazil; 4Clinical Research Laboratory, Dentistry School, Universidade Federal Fluminense, Niteroi, RJ, Brazil; 5Orthodontics Department, Dentistry School, Universidade Federal Fluminense, Niteroi, RJ, Brazil; 6Oral Surgery Department, Universidade Federal Fluminense, Niteroi, RJ, Brazil; 7Dental Research Division, Dentistry School, Universidade Paulista, São Paulo, SP, Brazil; 8Laboratory of Bioassays and Cell Dynamics, IBB-UNESP, Botucatu, Brazil; 9National Institute of Metrology, Quality and Technology (INMETRO), Duque de Caxias, RJ, BrazilCorrespondence: Monica Diuana Calasans-Maia; Jose Mauro GranjeiroUniversidade Federal Fluminense, Rua Mario Santos Braga, 28/4 Floor, Niteroi, RJ, BrazilTel +55 21 98153-5884Email monicacalasansmaia@gmail.com; jmgranjeiro@gmail.comBackground and Objective: The success rates of dental implants in low-density bone have been reported as a challenge, especially for early or immediate loading in the maxilla posterior area. Nanoscale architecture affects the roughness, surface area, surface energy of the implant and can enhance osseointegration. This study aimed to evaluate the implant-surface topography and biomechanical, histomorphometric, and histological bone responses to a new nanostructured hydroxyapatite surface placed in the iliac crest of sheep.Methods: Ten female sheep (2– 4 years) received 30 implants (n=10/group): HAnano® coated (Epikut Plus®, S.I.N. Implant System, Sao Paulo, SP, Brazil), SLActive (BLX®, Straumann, Basel, Switzerland), and TiUnite (NobelActive®, Nobel Biocare, Göteborg, Sweden) surfaces. Scanning electron microscopy with energy-dispersive spectroscopy evaluated the implant surface topography, the insertion torque value, and resonance frequency analysis evaluated the primary stability, bone-implant contact, and bone-area fraction occupancy were evaluated after 14 and 28 days after implant placement.Results: The surface morphology was considerably comparable between the implant groups’; however, the TiUnite® group presented a remarkable different surface. The SLActive® and TiUnite® groups presented an insertion torque average of 74 (± 8.9) N/cm that was similar to that of HAnano® 72 (± 8.3) N/cm (p > 0.05). The resonance frequency evaluated with Osstell®/SmartPeg® or Penguin®/MulTipeg® showed similar results when assessing implants from the same group. BIC and BAFO significantly increased (p< 0.05) throughout the experimental periods to all groups, but BIC and BAFO values were similar among the implants at the same time point. After 4 weeks, bone-implant contact was higher than 80% of the total length analyzed. New bone occupies around 60% of analyzed area around the implants.Conclusion: HAnano® coated surface promoted comparable osseointegration as SLActive and TiUnite in the sheep model. The three tested surfaces showed comparable osseointegration at the early stages of low-density bone repair in the sheep model.Keywords: osseointegration, dental implant surface, nanotechnology, hydroxyapatite, sheep, bone responseSartoretto SCCalasans-Maia JResende RCâmara EGhiraldini BBarbosa Bezerra FJGranjeiro JMCalasans-Maia MDDove Medical Pressarticleosseointegrationdental implant surfacenanotechnologyhydroxyapatitesheepbone responseMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 15, Pp 8803-8817 (2020)

The Influence of Nanostructured Hydroxyapatite Surface in the Early Stages of Osseointegration: A Multiparameter Animal Study in Low-Density Bone

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