Vitamin D and the immunomodulation of rotator cuff injury

Kaitlin A Dougherty,1 Matthew F Dilisio,2 Devendra K Agrawal1 1Department of Clinical & Translational Science, 2Department of Orthopedic Surgery, Creighton University School of Medicine, Omaha, NE, USA Abstract: Tendon-to-bone healing after rotator cuff repair surgery has a failure rate of 2...

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Autores principales:	Dougherty KA, Dilisio MF, Agrawal DK
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	Bone Calcium 1 25-Dihydroxyvitamin D Matrix metalloproteinases Muscle Rotator Cuff Tear Tendon Vitamin D Pathology RB1-214 Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/326e7e9dd9a84ce2ba0ac4d8d7109137
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spelling	oai:doaj.org-article:326e7e9dd9a84ce2ba0ac4d8d71091372021-12-02T07:25:06ZVitamin D and the immunomodulation of rotator cuff injury1178-7031https://doaj.org/article/326e7e9dd9a84ce2ba0ac4d8d71091372016-06-01T00:00:00Zhttps://www.dovepress.com/vitamin-d-and-the-immunomodulation-of-rotator-cuff-injury-peer-reviewed-article-JIRhttps://doaj.org/toc/1178-7031Kaitlin A Dougherty,1 Matthew F Dilisio,2 Devendra K Agrawal1 1Department of Clinical & Translational Science, 2Department of Orthopedic Surgery, Creighton University School of Medicine, Omaha, NE, USA Abstract: Tendon-to-bone healing after rotator cuff repair surgery has a failure rate of 20%–94%. There has been a recent interest to determine the factors that act as determinants between successful and unsuccessful rotator cuff repair. Vitamin D level in patients is one of the factors that have been linked to bone and muscle proliferation and healing, and it may have an effect on tendon-to-bone healing. The purpose of this article is to critically review relevant published research that relates to the effect of vitamin D on rotator cuff tears and subsequent healing. A review of the literature was conducted to identify all studies that investigate the relationship between vitamin D and tendon healing, in addition to its mechanism of action. The data were then analyzed in order to summarize what is currently known about vitamin D, rotator cuff pathology, and tendon-to-bone healing. The activated metabolite of vitamin D, 1α,25-dihydroxyvitamin D3, affects osteoblast proliferation and differentiation. Likewise, vitamin D plays a significant role in the tendon-to-bone healing process by increasing the bone mineral density and strengthening the skeletal muscles. The 1α,25-dihydroxyvitamin D3 binds to vitamin D receptors on myocytes to stimulate growth and proliferation. The form of vitamin D produced by the liver, calcifediol, is a key initiator of the myocyte healing process by moving phosphate into myocytes, which improves function and metabolism. Investigation into the effect of vitamin D on tendons has been sparse, but limited studies have been promising. Matrix metalloproteinases play an active role in remodeling the extracellular matrix (ECM) of tendons, particularly deleterious remodeling of the collagen fibers. Also, the levels of transforming growth factor-β3 positively influence the success of the surgery for rotator cuff repair. In the tendon-to-bone healing process, vitamin D has been shown to successfully influence bone and muscle healing, but more research is needed to delve into the mechanisms of vitamin D as a factor in skeletal tendon health and healing. Keywords: bone, calcium, 1,25-dihydroxyvitamin D, matrix metalloproteinases, muscle, rotator cuff tear, tendon Dougherty KADilisio MFAgrawal DKDove Medical PressarticleBoneCalcium125-Dihydroxyvitamin DMatrix metalloproteinasesMuscleRotator Cuff TearTendonVitamin DPathologyRB1-214Therapeutics. PharmacologyRM1-950ENJournal of Inflammation Research, Vol 2016, Iss Issue 1, Pp 123-131 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Bone Calcium 1 25-Dihydroxyvitamin D Matrix metalloproteinases Muscle Rotator Cuff Tear Tendon Vitamin D Pathology RB1-214 Therapeutics. Pharmacology RM1-950
spellingShingle	Bone Calcium 1 25-Dihydroxyvitamin D Matrix metalloproteinases Muscle Rotator Cuff Tear Tendon Vitamin D Pathology RB1-214 Therapeutics. Pharmacology RM1-950 Dougherty KA Dilisio MF Agrawal DK Vitamin D and the immunomodulation of rotator cuff injury
description	Kaitlin A Dougherty,1 Matthew F Dilisio,2 Devendra K Agrawal1 1Department of Clinical & Translational Science, 2Department of Orthopedic Surgery, Creighton University School of Medicine, Omaha, NE, USA Abstract: Tendon-to-bone healing after rotator cuff repair surgery has a failure rate of 20%–94%. There has been a recent interest to determine the factors that act as determinants between successful and unsuccessful rotator cuff repair. Vitamin D level in patients is one of the factors that have been linked to bone and muscle proliferation and healing, and it may have an effect on tendon-to-bone healing. The purpose of this article is to critically review relevant published research that relates to the effect of vitamin D on rotator cuff tears and subsequent healing. A review of the literature was conducted to identify all studies that investigate the relationship between vitamin D and tendon healing, in addition to its mechanism of action. The data were then analyzed in order to summarize what is currently known about vitamin D, rotator cuff pathology, and tendon-to-bone healing. The activated metabolite of vitamin D, 1α,25-dihydroxyvitamin D3, affects osteoblast proliferation and differentiation. Likewise, vitamin D plays a significant role in the tendon-to-bone healing process by increasing the bone mineral density and strengthening the skeletal muscles. The 1α,25-dihydroxyvitamin D3 binds to vitamin D receptors on myocytes to stimulate growth and proliferation. The form of vitamin D produced by the liver, calcifediol, is a key initiator of the myocyte healing process by moving phosphate into myocytes, which improves function and metabolism. Investigation into the effect of vitamin D on tendons has been sparse, but limited studies have been promising. Matrix metalloproteinases play an active role in remodeling the extracellular matrix (ECM) of tendons, particularly deleterious remodeling of the collagen fibers. Also, the levels of transforming growth factor-β3 positively influence the success of the surgery for rotator cuff repair. In the tendon-to-bone healing process, vitamin D has been shown to successfully influence bone and muscle healing, but more research is needed to delve into the mechanisms of vitamin D as a factor in skeletal tendon health and healing. Keywords: bone, calcium, 1,25-dihydroxyvitamin D, matrix metalloproteinases, muscle, rotator cuff tear, tendon
format	article
author	Dougherty KA Dilisio MF Agrawal DK
author_facet	Dougherty KA Dilisio MF Agrawal DK
author_sort	Dougherty KA
title	Vitamin D and the immunomodulation of rotator cuff injury
title_short	Vitamin D and the immunomodulation of rotator cuff injury
title_full	Vitamin D and the immunomodulation of rotator cuff injury
title_fullStr	Vitamin D and the immunomodulation of rotator cuff injury
title_full_unstemmed	Vitamin D and the immunomodulation of rotator cuff injury
title_sort	vitamin d and the immunomodulation of rotator cuff injury
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/326e7e9dd9a84ce2ba0ac4d8d7109137
work_keys_str_mv	AT doughertyka vitamindandtheimmunomodulationofrotatorcuffinjury AT dilisiomf vitamindandtheimmunomodulationofrotatorcuffinjury AT agrawaldk vitamindandtheimmunomodulationofrotatorcuffinjury
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Vitamin D and the immunomodulation of rotator cuff injury

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