The Oncogenic Role and Immune Infiltration for CARM1 Identified by Pancancer Analysis

Chromatin-modifying enzymes, especially protein arginine methyltransferases (PRMTs), have been identified as candidate targets for cancer. Cellular or animal-based evidence has suggested an association between coactivator-linked arginine methyltransferase 1 (CARM1) and cancer progression. However, t...

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Autores principales:	Kui Liu, Jing Ma, Jiao Ao, Lili Mu, Yixian Wang, Yue Qian, Jin Xue, Wei Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi Limited 2021
Materias:	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/327048e318794f6cb37936425030f959
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spelling	oai:doaj.org-article:327048e318794f6cb37936425030f9592021-11-08T02:36:40ZThe Oncogenic Role and Immune Infiltration for CARM1 Identified by Pancancer Analysis1687-846910.1155/2021/2986444https://doaj.org/article/327048e318794f6cb37936425030f9592021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/2986444https://doaj.org/toc/1687-8469Chromatin-modifying enzymes, especially protein arginine methyltransferases (PRMTs), have been identified as candidate targets for cancer. Cellular or animal-based evidence has suggested an association between coactivator-linked arginine methyltransferase 1 (CARM1) and cancer progression. However, the relationship between CARM1 and patient prognosis and immune infiltration in pancancer patients is unknown. On the basis of the GEO and TCGA databases, we first investigated the possible oncogenic functions of CARM1 in thirty-three tumor types. CARM1 expression was elevated in many types of tumors. In addition, there was a significant association between CARM1 expression and the survival rate of tumor patients. Uterine corpus endometrial carcinoma (UCES) samples had the highest CARM1 mutation frequency of all cancer types. In head and neck squamous cell carcinoma (HNSC) and lung squamous cell carcinoma (LUSC), CARM1 expression was associated with the level of CD8+ T cell infiltration, and cancer-associated fibroblast infiltration was also observed in other tumors including kidney renal papillary cell carcinoma (KIRC) and prostate adenocarcinoma (PRAD). CARM1 was involved in immune modulation and played an important role in the tumor microenvironment (TME). Furthermore, activities associated with RNA transport and its metabolism were included in the possible mechanisms of CARM1. Herein, our first pancancer research explores the oncogenic role of CARM1 in various tumors. CARM1 is associated with immune infiltrates and can be employed as a predictive biomarker in pancancer.Kui LiuJing MaJiao AoLili MuYixian WangYue QianJin XueWei ZhangHindawi LimitedarticleNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENJournal of Oncology, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Kui Liu Jing Ma Jiao Ao Lili Mu Yixian Wang Yue Qian Jin Xue Wei Zhang The Oncogenic Role and Immune Infiltration for CARM1 Identified by Pancancer Analysis
description	Chromatin-modifying enzymes, especially protein arginine methyltransferases (PRMTs), have been identified as candidate targets for cancer. Cellular or animal-based evidence has suggested an association between coactivator-linked arginine methyltransferase 1 (CARM1) and cancer progression. However, the relationship between CARM1 and patient prognosis and immune infiltration in pancancer patients is unknown. On the basis of the GEO and TCGA databases, we first investigated the possible oncogenic functions of CARM1 in thirty-three tumor types. CARM1 expression was elevated in many types of tumors. In addition, there was a significant association between CARM1 expression and the survival rate of tumor patients. Uterine corpus endometrial carcinoma (UCES) samples had the highest CARM1 mutation frequency of all cancer types. In head and neck squamous cell carcinoma (HNSC) and lung squamous cell carcinoma (LUSC), CARM1 expression was associated with the level of CD8+ T cell infiltration, and cancer-associated fibroblast infiltration was also observed in other tumors including kidney renal papillary cell carcinoma (KIRC) and prostate adenocarcinoma (PRAD). CARM1 was involved in immune modulation and played an important role in the tumor microenvironment (TME). Furthermore, activities associated with RNA transport and its metabolism were included in the possible mechanisms of CARM1. Herein, our first pancancer research explores the oncogenic role of CARM1 in various tumors. CARM1 is associated with immune infiltrates and can be employed as a predictive biomarker in pancancer.
format	article
author	Kui Liu Jing Ma Jiao Ao Lili Mu Yixian Wang Yue Qian Jin Xue Wei Zhang
author_facet	Kui Liu Jing Ma Jiao Ao Lili Mu Yixian Wang Yue Qian Jin Xue Wei Zhang
author_sort	Kui Liu
title	The Oncogenic Role and Immune Infiltration for CARM1 Identified by Pancancer Analysis
title_short	The Oncogenic Role and Immune Infiltration for CARM1 Identified by Pancancer Analysis
title_full	The Oncogenic Role and Immune Infiltration for CARM1 Identified by Pancancer Analysis
title_fullStr	The Oncogenic Role and Immune Infiltration for CARM1 Identified by Pancancer Analysis
title_full_unstemmed	The Oncogenic Role and Immune Infiltration for CARM1 Identified by Pancancer Analysis
title_sort	oncogenic role and immune infiltration for carm1 identified by pancancer analysis
publisher	Hindawi Limited
publishDate	2021
url	https://doaj.org/article/327048e318794f6cb37936425030f959
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The Oncogenic Role and Immune Infiltration for CARM1 Identified by Pancancer Analysis

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